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Synopsis

ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: Rad140, 1182367-47-0, Vosilasarm, Rad-140, 4o87q44knc, 2-chloro-4-[[(1r,2s)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino]-3-methylbenzonitrile
Molecular Formula
C20H16ClN5O2
Molecular Weight
393.8  g/mol
InChI Key
XMBUPPIEVAFYHO-KPZWWZAWSA-N
FDA UNII
4O87Q44KNC

Vosilasarm
Vosilasarm is an orally bioavailable, non-steroidal selective androgen receptor modulator (SARM), with potential tissue-selective androgenic/anti-androgenic activities. Upon oral administration, vosilasarm acts as an agonist in select tissues, such as skeletal muscle and bone, where it binds to and activates androgen receptors (ARs). In the prostate and breasts, RAD140 acts as an antagonist and blocks AR activation and AR-mediated cellular proliferation. Therefore, this agent may improve bone formation and muscle mass and strength, and may inhibit both the growth of the prostate in males and AR-dependent breast cancer cell proliferation. Compared to anabolic agents, SARMs have reduced androgenic properties.
1 2D Structure

Vosilasarm

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-chloro-4-[[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino]-3-methylbenzonitrile
2.1.2 InChI
InChI=1S/C20H16ClN5O2/c1-11-16(8-7-15(10-23)17(11)21)24-18(12(2)27)20-26-25-19(28-20)14-5-3-13(9-22)4-6-14/h3-8,12,18,24,27H,1-2H3/t12-,18+/m0/s1
2.1.3 InChI Key
XMBUPPIEVAFYHO-KPZWWZAWSA-N
2.1.4 Canonical SMILES
CC1=C(C=CC(=C1Cl)C#N)NC(C2=NN=C(O2)C3=CC=C(C=C3)C#N)C(C)O
2.1.5 Isomeric SMILES
CC1=C(C=CC(=C1Cl)C#N)N[C@@H](C2=NN=C(O2)C3=CC=C(C=C3)C#N)[C@H](C)O
2.2 Other Identifiers
2.2.1 UNII
4O87Q44KNC
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-chloro-4-(((1r,2s)-1-(5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl)-2-hydroxypropyl)amino)-3-methylbenzonitrile

2. Rad 140

3. Rad-140

4. Rad140

2.3.2 Depositor-Supplied Synonyms

1. Rad140

2. 1182367-47-0

3. Vosilasarm

4. Rad-140

5. 4o87q44knc

6. 2-chloro-4-[[(1r,2s)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino]-3-methylbenzonitrile

7. Chembl1672635

8. 2-chloro-4-(((1r,2s)-1-(5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl)-2-hydroxypropyl)amino)-3-methylbenzonitrile

9. 2-chloro-4-((1r,2s)-1-(5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl)-2-hydroxypropylamino)-3-methylbenzonitrile

10. Benzonitrile, 2-chloro-4-(((1r,2s)-1-(5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl)-2-hydroxypropyl)amino)-3-methyl-

11. Vosilasarm [inn]

12. Unii-4o87q44knc

13. Vosilasarm [who-dd]

14. Testolone [nflis-drug]

15. Schembl1363683

16. Ex-a725

17. Rad140,

18. Dtxsid201032907

19. Bcp16214

20. Bdbm50336997

21. Mfcd20527233

22. S5275

23. Zinc66097792

24. Ccg-268578

25. Cs-4670

26. Db13939

27. Ncgc00485476-01

28. 2-chloro-4-({1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl}amino)-3-methylbenzonitrile

29. Ac-30220

30. Hy-14383

31. J-690050

32. Q25099854

33. 2-chloro-4-[[(1r,2s)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazole-2-yl]-2-hydroxypropyl]amino]-3-methylbenzonitrile

2.4 Create Date
2009-09-21
3 Chemical and Physical Properties
Molecular Weight 393.8 g/mol
Molecular Formula C20H16ClN5O2
XLogP33.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass393.0992525 g/mol
Monoisotopic Mass393.0992525 g/mol
Topological Polar Surface Area119 Ų
Heavy Atom Count28
Formal Charge0
Complexity623
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

API SUPPLIERS

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API Reference Price

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25-May-2021
25-Oct-2024
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ABOUT THIS PAGE

Vosilasarm Manufacturers

A Vosilasarm manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Vosilasarm, including repackagers and relabelers. The FDA regulates Vosilasarm manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Vosilasarm API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Vosilasarm manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Vosilasarm Suppliers

A Vosilasarm supplier is an individual or a company that provides Vosilasarm active pharmaceutical ingredient (API) or Vosilasarm finished formulations upon request. The Vosilasarm suppliers may include Vosilasarm API manufacturers, exporters, distributors and traders.

click here to find a list of Vosilasarm suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Vosilasarm GMP

Vosilasarm Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Vosilasarm GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Vosilasarm GMP manufacturer or Vosilasarm GMP API supplier for your needs.

Vosilasarm CoA

A Vosilasarm CoA (Certificate of Analysis) is a formal document that attests to Vosilasarm's compliance with Vosilasarm specifications and serves as a tool for batch-level quality control.

Vosilasarm CoA mostly includes findings from lab analyses of a specific batch. For each Vosilasarm CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Vosilasarm may be tested according to a variety of international standards, such as European Pharmacopoeia (Vosilasarm EP), Vosilasarm JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Vosilasarm USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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