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Chemistry

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Also known as: 1243244-14-5, Lgk974, Lgk-974, Wnt-974, Wnt974, Lgk 974
Molecular Formula
C23H20N6O
Molecular Weight
396.4  g/mol
InChI Key
XXYGTCZJJLTAGH-UHFFFAOYSA-N
FDA UNII
U27F40013Q

WNT974
Porcupine Inhibitor WNT974 is an orally available inhibitor of porcupine (PORCN), with potential antineoplastic activity. Upon oral administration, WNT974 binds to and inhibits PORCN in the endoplasmic reticulum (ER), which blocks post-translational acylation of Wnt ligands and inhibits their secretion. This prevents the activation of Wnt ligands, interferes with Wnt-mediated signaling, and inhibits cell growth in Wnt-driven tumors. Porcupine, a membrane-bound O-acyltransferase (MBOAT), is required for the palmitoylation of Wnt ligands, and plays a key role in Wnt ligand secretion and activity. Wnt signaling is dysregulated in a variety of cancers.
1 2D Structure

WNT974

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[5-methyl-6-(2-methylpyridin-4-yl)pyridin-3-yl]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide
2.1.2 InChI
InChI=1S/C23H20N6O/c1-15-9-17(12-28-23(15)18-5-6-25-16(2)10-18)11-22(30)29-21-4-3-19(13-27-21)20-14-24-7-8-26-20/h3-10,12-14H,11H2,1-2H3,(H,27,29,30)
2.1.3 InChI Key
XXYGTCZJJLTAGH-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=CC(=CN=C1C2=CC(=NC=C2)C)CC(=O)NC3=NC=C(C=C3)C4=NC=CN=C4
2.2 Other Identifiers
2.2.1 UNII
U27F40013Q
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-(2',3-dimethyl-(2,4'-bipyridin)-5-yl)-n-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide

2. Lgk-974

3. Lgk974

4. Wnt-974

5. Wnt974

2.3.2 Depositor-Supplied Synonyms

1. 1243244-14-5

2. Lgk974

3. Lgk-974

4. Wnt-974

5. Wnt974

6. Lgk 974

7. Chebi:78030

8. Lgk974 (wnt974)

9. Chembl3188386

10. U27f40013q

11. 2-[5-methyl-6-(2-methyl-4-pyridyl)-3-pyridyl]-n-(5-pyrazin-2-yl-2-pyridyl)acetamide

12. 2-[5-methyl-6-(2-methylpyridin-4-yl)pyridin-3-yl]-n-(5-pyrazin-2-ylpyridin-2-yl)acetamide

13. [2,4'-bipyridine]-5-acetamide, 2',3-dimethyl-n-[5-(2-pyrazinyl)-2-pyridinyl]-

14. 2-(2',3-dimethyl-(2,4'-bipyridin)-5-yl)-n-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide

15. 2-(2',3-dimethyl-2,4'-bipyridin-5-yl)-n-[5-(pyrazin-2-yl)pyridin-2-yl]acetamide

16. 2-[(2p)-2',3-dimethyl[2,4'-bipyridin]-5-yl]-n-[(5p)-5-(pyrazin-2-yl)pyridin-2-yl]acetamide

17. Unii-u27f40013q

18. (2,4'-bipyridine)-5-acetamide, 2',3-dimethyl-n-(5-(2-pyrazinyl)-2-pyridinyl)-

19. O50

20. Porcn Inhibitor Iv

21. Nvp-lgk974

22. Mls006011002

23. Schembl1723611

24. Wnt-974 [who-dd]

25. Gtpl11167

26. Hms3653g11

27. Bcp08495

28. Ex-a1402

29. Lgk-974 (wnt974)

30. Bbl102809

31. Bdbm50133870

32. Cs3177

33. Mfcd27501026

34. Nsc777639

35. S7143

36. Stl556617

37. Zinc95930187

38. Akos025211913

39. Ccg-264701

40. Db12561

41. Nsc-777639

42. Sb19314

43. Ncgc00347950-01

44. Ncgc00347950-02

45. Ncgc00347950-07

46. Ncgc00347950-11

47. Ac-30231

48. Hy-17545

49. Ms-20504

50. Smr004702800

51. Sw211728-2

52. J3.551.731f

53. A890524

54. Au-004/43508401

55. J-005066

56. Q27147596

57. Lgk 974;lgk974; Wnt974; Wnt 974; Wnt-974

58. 2-(2',3-dimethyl-[2,4'-bipyridin]-5-yl)-n-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide;lgk974

2.4 Create Date
2010-11-01
3 Chemical and Physical Properties
Molecular Weight 396.4 g/mol
Molecular Formula C23H20N6O
XLogP31.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass396.16985928 g/mol
Monoisotopic Mass396.16985928 g/mol
Topological Polar Surface Area93.6 Ų
Heavy Atom Count30
Formal Charge0
Complexity560
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Enzyme Inhibitors

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)


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Looking for 1243244-14-5 / WNT974 API manufacturers, exporters & distributors?

WNT974 manufacturers, exporters & distributors 1

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PharmaCompass offers a list of WNT974 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right WNT974 manufacturer or WNT974 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred WNT974 manufacturer or WNT974 supplier.

PharmaCompass also assists you with knowing the WNT974 API Price utilized in the formulation of products. WNT974 API Price is not always fixed or binding as the WNT974 Price is obtained through a variety of data sources. The WNT974 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

WNT974

Synonyms

1243244-14-5, Lgk974, Lgk-974, Wnt-974, Lgk 974, Chebi:78030

Cas Number

1243244-14-5

Unique Ingredient Identifier (UNII)

U27F40013Q

About WNT974

Porcupine Inhibitor WNT974 is an orally available inhibitor of porcupine (PORCN), with potential antineoplastic activity. Upon oral administration, WNT974 binds to and inhibits PORCN in the endoplasmic reticulum (ER), which blocks post-translational acylation of Wnt ligands and inhibits their secretion. This prevents the activation of Wnt ligands, interferes with Wnt-mediated signaling, and inhibits cell growth in Wnt-driven tumors. Porcupine, a membrane-bound O-acyltransferase (MBOAT), is required for the palmitoylation of Wnt ligands, and plays a key role in Wnt ligand secretion and activity. Wnt signaling is dysregulated in a variety of cancers.

WNT974 Manufacturers

A WNT974 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of WNT974, including repackagers and relabelers. The FDA regulates WNT974 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. WNT974 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

WNT974 Suppliers

A WNT974 supplier is an individual or a company that provides WNT974 active pharmaceutical ingredient (API) or WNT974 finished formulations upon request. The WNT974 suppliers may include WNT974 API manufacturers, exporters, distributors and traders.

WNT974 GMP

WNT974 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of WNT974 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right WNT974 GMP manufacturer or WNT974 GMP API supplier for your needs.

WNT974 CoA

A WNT974 CoA (Certificate of Analysis) is a formal document that attests to WNT974's compliance with WNT974 specifications and serves as a tool for batch-level quality control.

WNT974 CoA mostly includes findings from lab analyses of a specific batch. For each WNT974 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

WNT974 may be tested according to a variety of international standards, such as European Pharmacopoeia (WNT974 EP), WNT974 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (WNT974 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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