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Chemistry

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Also known as: Xenon-133, Xenon xe 133, Xenon (133xe), Xenon, xe-133, 14932-42-4, Xenon (133 xe)
Molecular Formula
Xe
Molecular Weight
132.90591  g/mol
InChI Key
FHNFHKCVQCLJFQ-NJFSPNSNSA-N
FDA UNII
X3P9A5HNYF

Xenon Radioisotopes
Xenon Xe-133 is a radioisotope of xenon, an element with 54 protons, having gamma emissions and a physical half-life of 5.27 days. Xenon-133 is used in the study of pulmonary function and organ blood flow.
Xenon xe-133 is an Inhalation Diagnostic Agent. The mechanism of action of xenon xe-133 is as a Radiopharmaceutical Activity.
1 2D Structure

Xenon Radioisotopes

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
xenon-133
2.1.2 InChI
InChI=1S/Xe/i1+2
2.1.3 InChI Key
FHNFHKCVQCLJFQ-NJFSPNSNSA-N
2.1.4 Canonical SMILES
[Xe]
2.1.5 Isomeric SMILES
[133Xe]
2.2 Other Identifiers
2.2.1 UNII
X3P9A5HNYF
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 133xe Radioisotope

2. Xe-133 Radioisotope

3. Xenon-133

2.3.2 Depositor-Supplied Synonyms

1. Xenon-133

2. Xenon Xe 133

3. Xenon (133xe)

4. Xenon, Xe-133

5. 14932-42-4

6. Xenon (133 Xe)

7. Xenon (133xe) Gas

8. Xenon 133

9. X3p9a5hnyf

10. Xenon (133xe) [inn]

11. Xeneisol

12. Xenon Xe 133-v.s.s.

13. Xenonum (133 Xe)

14. Unii-x3p9a5hnyf

15. Xenon Xe 133 [usan]

16. Xenon, Isotope Of Mass 133

17. Mpi Xenon Xe 133 Gas Vials

18. Mpi Xenon Xe 133 Gas Ampule

19. Xe-133

20. Xenon Xe 133 [usan:usp]

21. Xenon ((sup 133)xe) Injection

22. Xenon Radioisotopes

23. Xenonum (133 Xe) [inn-latin]

24. 133xe Radioisotope

25. Xe-133 Radioisotope

26. Xenon,xe-133

27. Xenon (133xe) Injection

28. Xenon Xe 133 (tn)

29. Xenon Xe 133 Gas Vials

30. Xenon ((sup 133)xe)

31. Xenon Xe 133 Gas Ampule

32. Chembl1200685

33. Xenon Xe 133 [mi]

34. Xenon-133 [mart.]

35. Dtxsid70933614

36. Xenon,xe-133 [vandf]

37. 133xe

38. Xenon (133xe) [jan]

39. Xenon Xe 133 (jan/usp/inn)

40. Xenon (133 Xe) [who-dd]

41. Xenon Xe-133 [orange Book]

42. Db09315

43. Xenon Xe 133 [usp Monograph]

44. D06339

45. Q2451397

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 132.90591 g/mol
Molecular Formula Xe
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count0
Rotatable Bond Count0
Exact Mass132.90591 g/mol
Monoisotopic Mass132.90591 g/mol
Topological Polar Surface Area0 Ų
Heavy Atom Count1
Formal Charge0
Complexity0
Isotope Atom Count1
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameXenon xe 133
Active IngredientXenon xe-133
Dosage FormGas
RouteInhalation
Strength20mci/vial; 10mci/vial
Market StatusPrescription
CompanyLantheus Medcl

2 of 2  
Drug NameXenon xe 133
Active IngredientXenon xe-133
Dosage FormGas
RouteInhalation
Strength20mci/vial; 10mci/vial
Market StatusPrescription
CompanyLantheus Medcl

4.2 Drug Indication

Inhalation of Xenon Xe 133 Gas has proved valuable for the evaluation of pulmonary function and for imaging the lungs. It may also be applied to assessment of cerebral flow.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Xenon Xe 133 is a readily diffusible gas which is neither utilized nor produced by the body. It passes through cell membranes and freely exchanges between blood and tissue. It tends to concentrate more in body fat than in blood, plasma, water or protein solutions.


5.2 FDA Pharmacological Classification
5.2.1 Active Moiety
XENON XE-133
5.2.2 FDA UNII
X3P9A5HNYF
5.2.3 Pharmacological Classes
Radiopharmaceutical Activity [MoA]; Inhalation Diagnostic Agent [EPC]
5.3 ATC Code

V - Various

V09 - Diagnostic radiopharmaceuticals

V09E - Respiratory system

V09EX - Other respiratory system diagnostic radiopharmaceuticals

V09EX03 - Xenon (133Xe) gas


5.4 Absorption, Distribution and Excretion

Absorption

Inhaled Xenon Xe 133 Gas will enter the alveolar wall and enter the pulmonary venous circulation via the capillaries.


Route of Elimination

Most of the Xenon Xe 133 that enters the circulation from a single breath is returned to the lungs and exhaled after a single pass through the peripheral circulation.


5.5 Biological Half-Life

Half Life 5.245 days


5.6 Mechanism of Action

Xenon-133 is used for the diagnostic evaluation of pulmonary function and imaging, as well as assessment of cerebral blood flow. In the concentrations used for diagnostic purposes it is physiologically inactive.


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