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6 API Suppliers, 6 JDMF, 1 EU WC, 6 KDMF, $ API Reference Price

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6 JDMF
1 EU WC
6 KDMF
$ API Reference Price

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API REF. PRICE (USD/KG)

$ 293

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Chemistry

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Also known as: 74711-43-6, 2-(10-oxo-10,11-dihydrodibenzo[b,f]thiepin-2-yl)propanoic acid, 89482-00-8, Soleton, Cn-100, Soreton

Molecular Formula

C₁₇H₁₄O₃S

Molecular Weight

298.4 g/mol

InChI Key

MUXFZBHBYYYLTH-UHFFFAOYSA-N

FDA UNII

H8635NG3PY

A non-steroidal anti-inflammatory drug approved for use in Japan in 1993.

1 2D Structure

Zaltoprofen

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-(6-oxo-5H-benzo[b][1]benzothiepin-3-yl)propanoic acid

2.1.2 InChI

InChI=1S/C17H14O3S/c1-10(17(19)20)11-6-7-15-12(8-11)9-14(18)13-4-2-3-5-16(13)21-15/h2-8,10H,9H2,1H3,(H,19,20)

2.1.3 InChI Key

MUXFZBHBYYYLTH-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC(C1=CC2=C(C=C1)SC3=CC=CC=C3C(=O)C2)C(=O)O

2.2 Other Identifiers

2.2.1 UNII

H8635NG3PY

2.3 Synonyms

2.3.1 Depositor-Supplied Synonyms

1. 74711-43-6

2. 2-(10-oxo-10,11-dihydrodibenzo[b,f]thiepin-2-yl)propanoic Acid

3. 89482-00-8

4. Soleton

5. Cn-100

6. Soreton

7. Peon

8. Zaltoprofen [inn]

9. Cn 100

10. Zaltoprofene

11. Zaltoprofeno

12. Zaltoprofenum

13. Zaltoprofen [inn:jan]

14. Zaltoprofene [inn-french]

15. Zaltoprofenum [inn-latin]

16. 2-(10,11-dihydro-10-oxodibenzo[b,f]thiepin-2-yl)propionic Acid

17. Zaltoprofeno [inn-spanish]

18. 10,11-dihydro-alpha-methyl-10-oxodibenzo(b,f)thiepin-2-acetic Acid

19. H8635ng3py

20. Cn100

21. Zaltoprofen (+-)-

22. 2-(6-oxo-5h-benzo[b][1]benzothiepin-3-yl)propanoic Acid

23. Zaltoprofen Sodium Salt

24. Ncgc00183878-01

25. Dsstox_cid_29002

26. Dsstox_rid_83267

27. Dsstox_gsid_49076

28. Zaltoprofen (unspecified)

29. 10,11-dihydro-alpha-methyl-10-oxodibenzo[b,f]thiepin-2-acetic Acid

30. 2-(10-oxo-10,11-dihydrodibenzo-[b,f]thiepin-2-yl)propanoic Acid

31. Smr003500719

32. Cas-74711-43-6

33. Einecs 277-973-5

34. Unii-h8635ng3py

35. (+-)-10,11-dihydro-alpha-methyl-10-oxodibenzo(b,f)thiepin-2-acetic Acid

36. Peon (tn)

37. Zaltoprofen [mi]

38. Zaltoprofen [jan]

39. (+-)-2-(10,11-dihydro-10-oxodibenzo(b,f)thiepin-2-yl)propionic Acid

40. Zaltoprofen (jp17/inn)

41. Zaltoprofen [mart.]

42. Zaltoprofen [who-dd]

43. Mls004774050

44. Mls006010214

45. Schembl124047

46. Amy421

47. Chembl1765291

48. Dtxsid0049076

49. Chebi:32306

50. Hms3656j14

51. Hms3744o11

52. Hms3885e03

53. Bcp02387

54. Hy-b0619

55. Tox21_113634

56. 10,11-dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic Acid

57. Mfcd00864323

58. S3008

59. Zc-102

60. Akos015895991

61. Dibenzo(b,f)thiepin-2-acetic Acid, 10,11-dihydro-alpha-methyl-10-oxo-

62. Tox21_113634_1

63. Ccg-267450

64. Db06737

65. Gs-3949

66. Ncgc00263585-01

67. Ncgc00263585-04

68. Ac-32652

69. Ft-0630837

70. Ft-0656731

71. Sw219801-1

72. Z0021

73. D01547

74. Ab01565848_02

75. 711z436

76. A838204

77. F0001-2421

78. 2-(6-oxo-5a,6-dihydrodibenzo[b,f]thiepin-3-yl)propanoic Acid

79. 10,11-dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-aceticacid

80. 2-(10,11-dihydro-10-oxodibenzo [b,f] Thiepin-2-yl)propionic Acid

81. 2-(10,11-dihydro-10-oxodibenzo[b,f]thiepin-2-yl)-propionic Acid

82. 2-(10-oxo-10,11-dihydro-dibenzo[b,f]thiepin-2-yl)-propionic Acid

83. (alphar)-10,11-dihydro-alpha-methyl-10-oxodibenzo[b,f]thiepin-2-acetic Acid

84. (alphas)-10,11-dihydro-alpha-methyl-10-oxodibenzo[b,f]thiepin-2-acetic Acid

85. 1166864-09-0

86. 2-{10-oxo-2-thiatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-6-yl}propanoic Acid

2.4 Create Date

2005-03-25

3 Chemical and Physical Properties

Molecular Formula	C₁₇H₁₄O₃S
Molecular Weight	298.4 g/mol
XLogP3	3.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Exact Mass	298.06636548 g/mol
Monoisotopic Mass	298.06636548 g/mol
Topological Polar Surface Area	79.7 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	422
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 Metabolism/Metabolites

Zaltoprofen has known human metabolites that include (2S,3S,4S,5R)-3,4,5-trihydroxy-6-[2-(6-oxo-5H-benzo[b][1]benzothiepin-3-yl)propanoyloxy]oxane-2-carboxylic acid, 10-hydroxy-zaltoprofen, and Zaltoprofen S-oxide.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560

API SUPPLIERS

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JDMF

01

Daiwa Pharmaceutical Industries Co....

India

DDL Conference

Not Confirmed

02

Ipca Laboratories Limited

India

DDL Conference

Not Confirmed

03

Ipca Laboratories Limited

India

DDL Conference

Not Confirmed

04

KOLON LIFE SCIENCE, INC.

South Korea

DDL Conference

Not Confirmed

05

KOLON LIFE SCIENCE, INC.

South Korea

DDL Conference

Not Confirmed

06

Shin Poong Pharm. Co. , Ltd.

South Korea

DDL Conference

Not Confirmed

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EU WC

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KDMF

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API Reference Price

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ACTIVE PHARMA INGREDIENTS

6 API Suppliers

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6 KDMF

$ API Reference Price

DIGITAL CONTENT

1 NEWS #PharmaBuzz

ACTIVE PHARMA INGREDIENTS

API REF. PRICE (USD/KG)

$ 293

MARKET PLACE

0INTERMEDIATES

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0 DRUGS IN DEVELOPMENT

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DIGITAL CONTENT

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