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Chemistry

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Also known as: Bpn14770, Zatolmilast, 1606974-33-7, Bpn-14770, Zatolmilast [usan], Chembl4541964
Molecular Formula
C21H15ClF3NO2
Molecular Weight
405.8  g/mol
InChI Key
LTSUMTMGJHPGFX-UHFFFAOYSA-N
FDA UNII
G786V328X6

Zatolmilast
1 2D Structure

Zatolmilast

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl]methyl]phenyl]acetic acid
2.1.2 InChI
InChI=1S/C21H15ClF3NO2/c22-17-3-1-2-16(12-17)18-9-15(10-19(26-18)21(23,24)25)8-13-4-6-14(7-5-13)11-20(27)28/h1-7,9-10,12H,8,11H2,(H,27,28)
2.1.3 InChI Key
LTSUMTMGJHPGFX-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC(=CC(=C1)Cl)C2=NC(=CC(=C2)CC3=CC=C(C=C3)CC(=O)O)C(F)(F)F
2.2 Other Identifiers
2.2.1 UNII
G786V328X6
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Bpn14770

2.3.2 Depositor-Supplied Synonyms

1. Bpn14770

2. Zatolmilast

3. 1606974-33-7

4. Bpn-14770

5. Zatolmilast [usan]

6. Chembl4541964

7. G786v328x6

8. (4-{[2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl]methyl}phenyl)acetic Acid

9. 2-[4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl]methyl]phenyl]acetic Acid

10. Benzeneacetic Acid, 4-((2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl)methyl)-

11. 2-(4-{[2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl]methyl}phenyl)acetic Acid

12. Zatolmilast [inn]

13. Schembl15660260

14. Unii-g786v328x6

15. Gtpl10451

16. Ex-a5653

17. Bdbm50524994

18. S6844

19. Who 11495

20. Compound 28 [pmid: 31013090]

21. Hy-117571

22. Cs-0066529

23. Kr7

2.4 Create Date
2015-02-13
3 Chemical and Physical Properties
Molecular Weight 405.8 g/mol
Molecular Formula C21H15ClF3NO2
XLogP35.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass405.0743409 g/mol
Monoisotopic Mass405.0743409 g/mol
Topological Polar Surface Area50.2 Ų
Heavy Atom Count28
Formal Charge0
Complexity522
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Phosphodiesterase 4 Inhibitors

Compounds that specifically inhibit PHOSPHODIESTERASE 4. (See all compounds classified as Phosphodiesterase 4 Inhibitors.)


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ABOUT THIS PAGE

Zatolmilast Manufacturers

A Zatolmilast manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Zatolmilast, including repackagers and relabelers. The FDA regulates Zatolmilast manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Zatolmilast API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Zatolmilast Suppliers

A Zatolmilast supplier is an individual or a company that provides Zatolmilast active pharmaceutical ingredient (API) or Zatolmilast finished formulations upon request. The Zatolmilast suppliers may include Zatolmilast API manufacturers, exporters, distributors and traders.

Zatolmilast GMP

Zatolmilast Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Zatolmilast GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Zatolmilast GMP manufacturer or Zatolmilast GMP API supplier for your needs.

Zatolmilast CoA

A Zatolmilast CoA (Certificate of Analysis) is a formal document that attests to Zatolmilast's compliance with Zatolmilast specifications and serves as a tool for batch-level quality control.

Zatolmilast CoA mostly includes findings from lab analyses of a specific batch. For each Zatolmilast CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Zatolmilast may be tested according to a variety of international standards, such as European Pharmacopoeia (Zatolmilast EP), Zatolmilast JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Zatolmilast USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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