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Chemistry

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Also known as: Unii-4mod1f4enc, Ko539, Ko-539, 4mod1f4enc, 2134675-36-6, Menin-mll interaction inhibitor ko 539
Molecular Formula
C33H42F3N9O2S2
Molecular Weight
717.9  g/mol
InChI Key
BGGALFIXXQOTPY-NRFANRHFSA-N
FDA UNII
4MOD1F4ENC

Ziftomenib
Ziftomenib is an orally bioavailable inhibitor of the menin-mixed lineage leukemia (MLL; myeloid/lymphoid leukemia; KMT2A) fusion protein, with potential antineoplastic activity. Upon oral administration, ziftomenib prevents the interaction between the two proteins menin and MLL, and thus the formation of the menin-MLL complex. This reduces the expression of downstream target genes and results in an inhibition of the proliferation of MLL-rearranged leukemic cells. The menin-MLL complex plays a key role in the survival, growth and proliferation of certain kinds of leukemia cells.
1 2D Structure

Ziftomenib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-methyl-5-[[4-[[2-(methylamino)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-1-[(2S)-2-(4-methylsulfonylpiperazin-1-yl)propyl]indole-2-carbonitrile
2.1.2 InChI
InChI=1S/C33H42F3N9O2S2/c1-21(43-11-13-44(14-12-43)49(4,46)47)19-45-25(18-37)15-27-22(2)23(5-6-29(27)45)20-42-9-7-24(8-10-42)39-30-28-16-26(17-33(34,35)36)48-31(28)41-32(38-3)40-30/h5-6,15-16,21,24H,7-14,17,19-20H2,1-4H3,(H2,38,39,40,41)/t21-/m0/s1
2.1.3 InChI Key
BGGALFIXXQOTPY-NRFANRHFSA-N
2.1.4 Canonical SMILES
CC1=C(C=CC2=C1C=C(N2CC(C)N3CCN(CC3)S(=O)(=O)C)C#N)CN4CCC(CC4)NC5=C6C=C(SC6=NC(=N5)NC)CC(F)(F)F
2.1.5 Isomeric SMILES
CC1=C(C=CC2=C1C=C(N2C[C@H](C)N3CCN(CC3)S(=O)(=O)C)C#N)CN4CCC(CC4)NC5=C6C=C(SC6=NC(=N5)NC)CC(F)(F)F
2.2 Other Identifiers
2.2.1 UNII
4MOD1F4ENC
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Unii-4mod1f4enc

2. Ko539

3. Ko-539

4. 4mod1f4enc

5. 2134675-36-6

6. Menin-mll Interaction Inhibitor Ko 539

7. (s)-4-methyl-5-((4-((2-(methylamino)-6-(2,2,2-trifluoroethyl)thieno(2,3-d)pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1-(2-(4-(methylsulfonyl)piperazin-1-yl)propyl)-1h-indole-2-carbonitrile

8. 4-methyl-5-[[4-[[2-(methylamino)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-1-[(2s)-2-(4-methylsulfonylpiperazin-1-yl)propyl]indole-2-carbonitrile

9. Ziftomenib [usan]

10. Ko-539;ziftomenibum

11. Ziftomenib [inn]

12. Ko 539 [who-dd]

13. Schembl20846943

14. Gtpl11680

15. Ex-a5611

16. Who 11651

17. Compound 151 [us10781218b2]

18. Hy-132001

19. Cs-0146342

20. 1h-indole-2-carbonitrile, 4-methyl-5-((4-((2-(methylamino)-6-(2,2,2-trifluoroethyl)thieno(2,3-d)pyrimidin-4-yl)amino)-1-piperidinyl)methyl)-1-((2s)-2-(4-(methylsulfonyl)-1-piperazinyl)propyl)-

2.4 Create Date
2019-07-20
3 Chemical and Physical Properties
Molecular Weight 717.9 g/mol
Molecular Formula C33H42F3N9O2S2
XLogP35.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count14
Rotatable Bond Count10
Exact Mass717.28549845 g/mol
Monoisotopic Mass717.28549845 g/mol
Topological Polar Surface Area159 Ų
Heavy Atom Count49
Formal Charge0
Complexity1270
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Ziftomenib Manufacturers

A Ziftomenib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ziftomenib, including repackagers and relabelers. The FDA regulates Ziftomenib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ziftomenib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Ziftomenib Suppliers

A Ziftomenib supplier is an individual or a company that provides Ziftomenib active pharmaceutical ingredient (API) or Ziftomenib finished formulations upon request. The Ziftomenib suppliers may include Ziftomenib API manufacturers, exporters, distributors and traders.

Ziftomenib GMP

Ziftomenib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Ziftomenib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ziftomenib GMP manufacturer or Ziftomenib GMP API supplier for your needs.

Ziftomenib CoA

A Ziftomenib CoA (Certificate of Analysis) is a formal document that attests to Ziftomenib's compliance with Ziftomenib specifications and serves as a tool for batch-level quality control.

Ziftomenib CoA mostly includes findings from lab analyses of a specific batch. For each Ziftomenib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Ziftomenib may be tested according to a variety of international standards, such as European Pharmacopoeia (Ziftomenib EP), Ziftomenib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ziftomenib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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