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8 RELATED EXCIPIENT COMPANIES

16EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 3486-35-9, Zinc monocarbonate, Zinc;carbonate, Carbonic acid, zinc salt (1:1), Zinccarbonate, Zinc carbonate (1:1)
Molecular Formula
CO3Zn
Molecular Weight
125.4  g/mol
InChI Key
FMRLDPWIRHBCCC-UHFFFAOYSA-L
FDA UNII
K8290PTQ4F

Zinc Carbonate
1 2D Structure

Zinc Carbonate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
zinc;carbonate
2.1.2 InChI
InChI=1S/CH2O3.Zn/c2-1(3)4;/h(H2,2,3,4);/q;+2/p-2
2.1.3 InChI Key
FMRLDPWIRHBCCC-UHFFFAOYSA-L
2.1.4 Canonical SMILES
C(=O)([O-])[O-].[Zn+2]
2.2 Other Identifiers
2.2.1 UNII
K8290PTQ4F
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 3486-35-9

2. Zinc Monocarbonate

3. Zinc;carbonate

4. Carbonic Acid, Zinc Salt (1:1)

5. Zinccarbonate

6. Zinc Carbonate (1:1)

7. Ci 77950

8. Zinc Oxide Transparent

9. C.i. 77950

10. K8290ptq4f

11. Zincspar

12. Natural Smithsonite

13. Hsdb 1048

14. Einecs 222-477-6

15. Unii-k8290ptq4f

16. Zinc Carbonic Acid

17. Zinc(ii) Carbonate

18. Carbonic Acid Zinc Salt

19. Zinc Carbonate [mi]

20. Schembl20746

21. Dtxsid5049817

22. Zinc Monocarbonate [hsdb]

23. Chebi:184449

24. Zinc(+2) Cation Carbonate

25. Mfcd00041957

26. 10476-83-2

27. C.i.77950

28. Ft-0774765

29. Q204661

2.4 Create Date
2005-07-19
3 Chemical and Physical Properties
Molecular Weight 125.4 g/mol
Molecular Formula CO3Zn
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count0
Exact Mass123.913886 g/mol
Monoisotopic Mass123.913886 g/mol
Topological Polar Surface Area63.2 Ų
Heavy Atom Count5
Formal Charge0
Complexity18.8
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Therapeutic Uses

MEDICATION (VET): ASTRINGENT, ANTISEPTIC, PROTECTIVE (TOPICAL). ALSO USED IN RATIONS TO PREVENT ZINC DEFICIENCY DISEASES.

Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989., p. 1598


MEDICATION (VET): Zinc carbonate is used as a dietary supplement for farm animals.

Seiler, H.G., H. Sigel and A. Sigel (eds.). Handbook on the Toxicity of Inorganic Compounds. New York, NY: Marcel Dekker, Inc. 1988., p. 789


Astringent, topical antiseptic.

Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989., p. 1598


5 Pharmacology and Biochemistry
5.1 Absorption, Distribution and Excretion

The effects of different amounts of dietary zinc on the zinc absorption rate and on zinc, calcium and magnesium concn in tissues of MOPC104E tumor bearing Balb/c female mice were determined. Three groups of 7 mice each (each mouse inoculated with approx 1.25 million MOPC104E cells) were given one of three experimental diets containing adequate amounts of zinc (40 ug zinc/g), a zinc deficient diet (1.0 ug zinc/g), or a zinc excess diet (1 mg zinc/g). A group of 7 nontumor bearing mice was fed laboratory mice chow as a control. The zinc deficient diet contained 37.5 ug zinc/g. For the zinc adequate diet, 71.0 mg zinc carbonate/kg diet was added to the zinc deficient diet. For the zinc excess diet 1917.9 mg zinc carbonate/kg diet was added. After 14 days on the special diets, mice were given an intragastric dose of a 200 ul solution containing 0.37 MBq (65)zinc (specific activity: 37 MBq/mg). (65)Zn was determined in various organs by gamma counting. Another set of 28 mice were placed in the same experimental conditions as described above. After anesthesia with nembutal injection, each organ was analyzed for concn of zinc, calcium, and magnesium by atomic absorption spectrophotometry. The zinc absorption rate was inversely related to the amounts of zinc in the diet and was lower than that of nontumor bearing control mice fed a laboratory mice chow. Zinc concn of tumor bearing mice were also low compared with control mice but tumor zinc concn, regardless of the concn of zinc in the diets, were higher than those of normal tissues of the host other than the pancreas.

PMID:2929490 Song MK et al; Am J Clin Nutr 49 (4): 701-7 (1989)


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