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Chemistry

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Also known as: 7646-85-7, Zinc dichloride, Butter of zinc, Zinc(ii) chloride, Zinc butter, Zinkchloride
Molecular Formula
Cl2Zn
Molecular Weight
136.3  g/mol
InChI Key
JIAARYAFYJHUJI-UHFFFAOYSA-L

Zinc Dichloride
Zinc Chloride is an ionic salt essential for the synthesis of cholesterol, protein, and fats. Zinc plays an important role in the proper functioning of the immune system. Zinc is required for the enzyme activities necessary for cell division, cell growth, and wound healing as well as the release of vitamin A from the liver. It plays a role in the acuity of the senses of smell and taste and is required to maintain prostate reproductive health and insulin function. Zinc is also involved in the metabolism of carbohydrates. Zinc chloride is administered orally or parenterally as a nutritional supplement.
1 2D Structure

Zinc Dichloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
dichlorozinc
2.1.2 InChI
InChI=1S/2ClH.Zn/h2*1H;/q;;+2/p-2
2.1.3 InChI Key
JIAARYAFYJHUJI-UHFFFAOYSA-L
2.1.4 Canonical SMILES
Cl[Zn]Cl
2.2 Synonyms
2.2.1 Depositor-Supplied Synonyms

1. 7646-85-7

2. Zinc Dichloride

3. Butter Of Zinc

4. Zinc(ii) Chloride

5. Zinc Butter

6. Zinkchloride

7. Zintrace

8. Zinc Chloride (zncl2)

9. Zinc Chloride Fume

10. Zinc Chloride, (solution)

11. Mfcd00011295

12. Zinc (chlorure De)

13. Zinco (cloruro Di)

14. Zinc Chloride, Solution

15. Zinc Chloride, Ultra Dry

16. Zinc Chloride Solution Anhydrous

17. Zinc Chloride Solution, 1.9 M In 2-methyltetrahydrofuran

18. Zine Dichloride

19. Zinkchlorid [german]

20. Zinkchloride [dutch]

21. Zinc Chloride Solution

22. Caswell No. 910

23. Chlorure De Zinc [french]

24. Zinc (chlorure De) [french]

25. Ccris 3509

26. Zinc Chloride 0.1 M Solution

27. Zinco (cloruro Di) [italian]

28. Hsdb 1050

29. Einecs 231-592-0

30. Un1840

31. Un2331

32. Zinc Chloride (tn)

33. Epa Pesticide Chemical Code 087801

34. Nsc 529648

35. Zinc Muriate, Solution

36. Ai3-04470

37. Zinc Chloride [usp:jan]

38. Dsstox_cid_15013

39. Dsstox_rid_79237

40. Wln: Zn G2

41. Dsstox_gsid_35013

42. Zinc Chloride (jp17/usp)

43. Zinc Chloride, Lr, >=97%

44. Unii-86q357l16b

45. Zinc Chloride, P.a., 97.0%

46. Zinc Chloride In Plastic Container

47. Tox21_301492

48. Zinc Chloride, 1.9m In 2-methf

49. Zinc Chloride, For Molecular Biology

50. Zinc Chloride, 25mm Aqueous Solution

51. Akos016017250

52. Zinc Chloride, 0.5m Solution In Thf

53. Zinc Chloride, 0.7m Solution In Thf

54. Zinc Chloride, Acs Reagent, >=97%

55. Zinc Chloride, Reagent Grade, >=98%

56. Zinc Chloride Solution, 0.5 M In Thf

57. Ncgc00255612-01

58. Zinc Chloride (99.99%-zn) Puratrem

59. Cas-7646-85-7

60. Ft-0645122

61. Zinc Chloride, 99.999% Trace Metals Basis

62. Zinc Chloride, Saj First Grade, >=95.0%

63. Zinc Chloride, Jis Special Grade, >=98.0%

64. D02058

65. Ec 231-592-0

66. Zinc Chloride Solution, 1.0 M In Diethyl Ether

67. Zinc Chloride, Solution [un1840] [corrosive]

68. Q204714

69. Zinc Chloride, Anhydrous [un2331] [corrosive]

70. Brd-k46586998-001-01-1

71. Zinc Chloride, Bioreagent, For Molecular Biology, >=97.0%

72. Zinc Chloride, Anhydrous, Powder, >=99.995% Trace Metals Basis

73. Zinc Chloride, Anhydrous, Free-flowing, Redi-dri(tm), Acs Reagent, >=97%

74. Zinc Chloride, 1m In Diethyl Ether, Packaged Under Argon In Resealable Chemseal Bottles

75. Zinc Chloride, Anhydrous, Beads, Amorphous, -10 Mesh, 99.99% Trace Metals Basis

76. Zinc Chloride, Anhydrous, Beads, Amorphous, -10 Mesh, 99.999% Trace Metals Basis

77. Zinc Chloride, Anhydrous, Free-flowing, Redi-dri(tm), Reagent Grade, >=98%

78. Zinc Chloride, Puriss. P.a., Acs Reagent, Reag. Iso, Reag. Ph. Eur., >=98%

79. Zinc Chloride, Puriss., Meets Analytical Specification Of Ph. Eur., Bp, Usp, 98-100.5%

80. Zinc Atomic Spectroscopy Standard Concentrate 1.00 G Zn, 1.00 G/l, For 1l Standard Solution, Analytical Standard

81. Zinc Chloride, Bioreagent, For Molecular Biology, Suitable For Cell Culture, Suitable For Insect Cell Culture

2.3 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 136.3 g/mol
Molecular Formula Cl2Zn
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count0
Rotatable Bond Count0
Exact Mass133.866847 g/mol
Monoisotopic Mass133.866847 g/mol
Topological Polar Surface Area0 Ų
Heavy Atom Count3
Formal Charge0
Complexity2.8
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameZinc chloride in plastic container
Active IngredientZinc chloride
Dosage FormInjectable
RouteInjection
Strengtheq 1mg zinc/ml
Market StatusPrescription
CompanyHospira

2 of 2  
Drug NameZinc chloride in plastic container
Active IngredientZinc chloride
Dosage FormInjectable
RouteInjection
Strengtheq 1mg zinc/ml
Market StatusPrescription
CompanyHospira

4.2 Therapeutic Uses

Mesh Heading: Mouthwashes

National Library of Medicine, SIS; ChemIDplus Record for Zinc Chloride (7646-85-7). Available from, as of April 17, 2006: https://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp


In low concentrations it is astringent and mildly antibacterial. It is used in vaginal douches to supress trichomonal and hemophilus infections. Although it is used in mouthwashes, contact time is too short, and only astringent and not antibacterial action results.

Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 722


MEDICATION (VET): Rare as caustic in fistulas (20% solution), as paste in chemotherapy of cancers, and on ulcers (2-4%). Some may still use it as antiseptic astringent on eye infections (0.1-0.2% solution).

Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 668


Astringent for corn and callus treatment

SRI


For more Therapeutic Uses (Complete) data for ZINC CHLORIDE (10 total), please visit the HSDB record page.


4.3 Drug Warning

FDA Pregnancy Risk Category: C /RISK CANNOT BE RULED OUT. Adequate, well controlled human studies are lacking, and animal studies have shown risk to the fetus or are lacking as well. There is a chance of fetal harm if the drug is given during pregnancy; but the potential benefits may outweigh the potential risk./ /Zinc supplements; parenteral zinc/

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006.


Zinc supplements should be taken at least 1 hour before or 2 hours after meals, since many foods may impair the absorption of zinc. If gastric irritation occurs, then zinc supplements may be taken with meals; however, the zinc will be less bioavailable. /Zinc supplements/

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006.


In most cases, parenteral administration is indicated only when oral administration is not acceptable (for example, in nausea, vomiting, preoperative and postoperative conditions) or possible (for example, in malabsorption syndromes or following gastric resection). /Zinc supplements/

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006.


Zinc injection that contains benzyl alcohol as a preservative should not be used in newborn and immature infants. The use of benzyl alcohol in neonates has been associated with a fatal toxic syndrome consisting of metabolic acidosis and CNS, respiratory, circulatory, and renal function impairment. /Zinc supplements/

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006.


For more Drug Warnings (Complete) data for ZINC CHLORIDE (6 total), please visit the HSDB record page.


5 Pharmacology and Biochemistry
5.1 FDA Pharmacological Classification
5.1.1 Pharmacological Classes
Decreased Copper Ion Absorption [PE]; Copper Absorption Inhibitor [EPC]
5.2 ATC Code

B - Blood and blood forming organs

B05 - Blood substitutes and perfusion solutions

B05X - I.v. solution additives

B05XA - Electrolyte solutions

B05XA12 - Zinc chloride


5.3 Absorption, Distribution and Excretion

In humans subjected to low doses of (65)zinc chloride and whole-body measurements ... /it was/ estimated absorption to range from 58% to 77% in 5 controls, and from 16% to 42% in 3 patients suffering from acrodermatitis enterohepatica. The whole-body zinc retention was measured for 34 days ... One week after oral tracer dose of 2 ug zinc chloride to mice, the highest concentrations were found in bone tissue followed by liver and kidney.

Friberg, L., Nordberg, G.F., Kessler, E. and Vouk, V.B. (eds). Handbook of the Toxicology of Metals. 2nd ed. Vols I, II.: Amsterdam: Elsevier Science Publishers B.V., 1986., p. II:669


The whole-body retention at 95 hr after intravascular injection of carrier-free (65)zinc chloride to mature male rats amounted to 78.3% of the dose.

Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. 2:261


In one study, 95 hr after injection of (65)zinc chloride to rats, 20.1% of the dose was recovered in feces and only 0.6% in urine ...

Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. 2:262


In mice given 0.3 ugzinc chloride iv, about 50% of the total dose was recovered in feces within a week. the corresponding value in 1 wk for dogs given 6.5 ug zinc chloride was about 20%. Urinary excretion for the same period was well below 5% of the dose in both species ... Biliary excretion of zinc in rats was found to be 4% over a period of 48 hr following a single iv dose of 0.1 mg (65)zinc chloride.

Friberg, L., Nordberg, G.F., Kessler, E. and Vouk, V.B. (eds). Handbook of the Toxicology of Metals. 2nd ed. Vols I, II.: Amsterdam: Elsevier Science Publishers B.V., 1986., p. II670


For more Absorption, Distribution and Excretion (Complete) data for ZINC CHLORIDE (17 total), please visit the HSDB record page.


5.4 Biological Half-Life

For zinc, whole body: 162-500 days; [TDR, p. 1245]

TDR - Ryan RP, Terry CE, Leffingwell SS (eds). Toxicology Desk Reference: The Toxic Exposure and Medical Monitoring Index, 5th Ed. Washington DC: Taylor & Francis, 1999., p. 1245


5.5 Mechanism of Action

Hepatocytes were grown in monolayer culture for 22 hr and subsequently treated with zinc chloride (100 uM) for 24 hr which produced a 15-fold increase in metallothionein proteins (MT) concentration. Following pretreatment with zinc chloride, hepatocytes were treated with 20 or 40 uM silver nitrate for 24 hr, and cytotoxicity was then assessed by enzyme leakage and loss of intracellular potassium. The toxicity of silver was significantly less in the zinc-pretreated cells. Furthermore, although zinc pretreatment had no appreciable effect on the hepatocellular uptake of silver, it did alter the subcellular distribution, and silver accumulated more in the cytosol and less in the nuclear, mitochondrial, and microsomal fractions. Silver in the cytosol of control cells was bound primarily to high molecular weight proteins, whereas silver was mainly associated with MT in the zinc-pretreated cells. Zinc-induced MT in rat primary hepatocyte cultures protects against silver-induced cytotoxicity which results from the binding of silver to MT with a concomitant reduction of metal content in critical organelles and proteins.

Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. 2:142


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ABOUT THIS PAGE

Looking for 7646-85-7 / Zinc Dichloride API manufacturers, exporters & distributors?

Zinc Dichloride manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Zinc Dichloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Zinc Dichloride manufacturer or Zinc Dichloride supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Zinc Dichloride manufacturer or Zinc Dichloride supplier.

PharmaCompass also assists you with knowing the Zinc Dichloride API Price utilized in the formulation of products. Zinc Dichloride API Price is not always fixed or binding as the Zinc Dichloride Price is obtained through a variety of data sources. The Zinc Dichloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Zinc Dichloride

Synonyms

7646-85-7, Butter of zinc, Zinc(ii) chloride, Zinc butter, Zinkchloride, Zintrace

Cas Number

7646-85-7

About Zinc Dichloride

Zinc Chloride is an ionic salt essential for the synthesis of cholesterol, protein, and fats. Zinc plays an important role in the proper functioning of the immune system. Zinc is required for the enzyme activities necessary for cell division, cell growth, and wound healing as well as the release of vitamin A from the liver. It plays a role in the acuity of the senses of smell and taste and is required to maintain prostate reproductive health and insulin function. Zinc is also involved in the metabolism of carbohydrates. Zinc chloride is administered orally or parenterally as a nutritional supplement.

Zinc Dichloride Manufacturers

A Zinc Dichloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Zinc Dichloride, including repackagers and relabelers. The FDA regulates Zinc Dichloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Zinc Dichloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Zinc Dichloride Suppliers

A Zinc Dichloride supplier is an individual or a company that provides Zinc Dichloride active pharmaceutical ingredient (API) or Zinc Dichloride finished formulations upon request. The Zinc Dichloride suppliers may include Zinc Dichloride API manufacturers, exporters, distributors and traders.

click here to find a list of Zinc Dichloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Zinc Dichloride USDMF

A Zinc Dichloride DMF (Drug Master File) is a document detailing the whole manufacturing process of Zinc Dichloride active pharmaceutical ingredient (API) in detail. Different forms of Zinc Dichloride DMFs exist exist since differing nations have different regulations, such as Zinc Dichloride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Zinc Dichloride DMF submitted to regulatory agencies in the US is known as a USDMF. Zinc Dichloride USDMF includes data on Zinc Dichloride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Zinc Dichloride USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Zinc Dichloride suppliers with USDMF on PharmaCompass.

Zinc Dichloride CEP

A Zinc Dichloride CEP of the European Pharmacopoeia monograph is often referred to as a Zinc Dichloride Certificate of Suitability (COS). The purpose of a Zinc Dichloride CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Zinc Dichloride EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Zinc Dichloride to their clients by showing that a Zinc Dichloride CEP has been issued for it. The manufacturer submits a Zinc Dichloride CEP (COS) as part of the market authorization procedure, and it takes on the role of a Zinc Dichloride CEP holder for the record. Additionally, the data presented in the Zinc Dichloride CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Zinc Dichloride DMF.

A Zinc Dichloride CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Zinc Dichloride CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Zinc Dichloride suppliers with CEP (COS) on PharmaCompass.

Zinc Dichloride NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Zinc Dichloride as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Zinc Dichloride API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Zinc Dichloride as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Zinc Dichloride and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Zinc Dichloride NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Zinc Dichloride suppliers with NDC on PharmaCompass.

Zinc Dichloride GMP

Zinc Dichloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Zinc Dichloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Zinc Dichloride GMP manufacturer or Zinc Dichloride GMP API supplier for your needs.

Zinc Dichloride CoA

A Zinc Dichloride CoA (Certificate of Analysis) is a formal document that attests to Zinc Dichloride's compliance with Zinc Dichloride specifications and serves as a tool for batch-level quality control.

Zinc Dichloride CoA mostly includes findings from lab analyses of a specific batch. For each Zinc Dichloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Zinc Dichloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Zinc Dichloride EP), Zinc Dichloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Zinc Dichloride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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