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Zinc(II) Gluconate

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Also known as: 4468-02-4, Zincgluconate, Zincum gluconicum, Gluconic acid zinc complex, Zinc d-gluconate (1:2), Bis(d-gluconato-o1,o2) zinc

Molecular Formula

C₁₂H₂₂O₁₄Zn

Molecular Weight

455.7 g/mol

InChI Key

WHMDKBIGKVEYHS-IYEMJOQQSA-L

FDA UNII

U6WSN5SQ1Z

Zinc Gluconate is a nutritional supplement containing the zinc salt form of gluconic acid for the purpose of providing zinc. As an essential trace element, zinc is of key importance in many biological processes, acts as an antioxidant and strengthens the immune system. Although the mechanism of action is not completely known, zinc supplementation may be used to increase immunity against viruses or may interfere with the replication of certain viruses, such as the human papillomavirus (HPV).

1 2D Structure

Zinc(II) Gluconate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

zinc;(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate

2.1.2 InChI

InChI=1S/2C6H12O7.Zn/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;/h2*2-5,7-11H,1H2,(H,12,13);/q;;+2/p-2/t2*2-,3-,4+,5-;/m11./s1

2.1.3 InChI Key

WHMDKBIGKVEYHS-IYEMJOQQSA-L

2.1.4 Canonical SMILES

C(C(C(C(C(C(=O)[O-])O)O)O)O)O.C(C(C(C(C(C(=O)[O-])O)O)O)O)O.[Zn+2]

2.1.5 Isomeric SMILES

C([C@H]([C@H]([C@@H]([C@H](C(=O)[O-])O)O)O)O)O.C([C@H]([C@H]([C@@H]([C@H](C(=O)[O-])O)O)O)O)O.[Zn+2]

2.2 Other Identifiers

2.2.1 UNII

U6WSN5SQ1Z

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Boron Gluconate

2. D-gluconate

3. D-gluconic Acid

4. Dextronic Acid

5. Gluconate

6. Gluconic Acid

7. Gluconic Acid, (113)indium-labeled

8. Gluconic Acid, (14)c-labeled

9. Gluconic Acid, (159)dysprosium-labeled Salt

10. Gluconic Acid, (99)technecium (5+) Salt

11. Gluconic Acid, 1-(14)c-labeled

12. Gluconic Acid, 6-(14)c-labeled

13. Gluconic Acid, Aluminum (3:1) Salt

14. Gluconic Acid, Ammonium Salt

15. Gluconic Acid, Calcium Salt

16. Gluconic Acid, Cesium(+3) Salt

17. Gluconic Acid, Cobalt (2:1) Salt

18. Gluconic Acid, Copper Salt

19. Gluconic Acid, Fe(+2) Salt, Dihydrate

20. Gluconic Acid, Lanthanum(+3) Salt

21. Gluconic Acid, Magnesium (2:1) Salt

22. Gluconic Acid, Manganese (2:1) Salt

23. Gluconic Acid, Monolithium Salt

24. Gluconic Acid, Monopotassium Salt

25. Gluconic Acid, Monosodium Salt

26. Gluconic Acid, Potassium Salt

27. Gluconic Acid, Sodium Salt

28. Gluconic Acid, Strontium (2:1) Salt

29. Gluconic Acid, Tin(+2) Salt

30. Gluconic Acid, Zinc Salt

31. Lithium Gluconate

32. Magnerot

33. Magnesium Gluconate

34. Maltonic Acid

35. Manganese Gluconate

36. Pentahydroxycaproic Acid

37. Sodium Gluconate

2.3.2 Depositor-Supplied Synonyms

1. 4468-02-4

2. Zincgluconate

3. Zincum Gluconicum

4. Gluconic Acid Zinc Complex

5. Zinc D-gluconate (1:2)

6. Bis(d-gluconato-o1,o2) Zinc

7. Gluconic Acid Zinc(ii) Salt

8. Zinc Gluconate (usp)

9. U6wsn5sq1z

10. Zinc, Bis(d-gluconato-kappao1,kappao2)-, (t-4)-

11. Gluconic Acid Zinc

12. Zinc(ii) Gluconate

13. Schembl21280

14. Zinc Gluconate [fcc]

15. Zinc Gluconate [hsdb]

16. Zinc Gluconate [inci]

17. Zinc Gluconate [vandf]

18. Zinc Gluconate [mart.]

19. Chembl3833377

20. Zinc Gluconate [who-dd]

21. Zincum Gluconicum [hpus]

22. Chebi:29708

23. Dtxsid20894125

24. Zinc Gluconate [green Book]

25. Zinc Gluconate [ep Impurity]

26. Zinc Gluconate [ep Monograph]

27. Akos015951235

28. Zinc Gluconate [usp Monograph]

29. Db11248

30. Gluconic Acid Zinc Complex [mi]

31. G0277

32. D02390

33. F71322

34. A826659

35. Q-201160

36. Q3822815

37. Zinc(ii) (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoate

38. Zinc (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoate;zinc Gluconate Hydrate

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₂H₂₂O₁₄Zn
Molecular Weight	455.7 g/mol
Hydrogen Bond Donor Count	10
Hydrogen Bond Acceptor Count	14
Rotatable Bond Count	8
Exact Mass	454.030097 g/mol
Monoisotopic Mass	454.030097 g/mol
Topological Polar Surface Area	283 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	165
Isotope Atom Count	0
Defined Atom Stereocenter Count	8
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Drug and Medication Information

4.1 Therapeutic Uses

MEDICATION (VET): CATTLE DERMATOMYCOSIS, CAUSED BY TRICHOPHYTON VERRUCOSUM (TRICHOPHYTOSIS) WAS TREATED BY ORAL ADMIN OF PREPN CONTAINING 20-70% ZINC GLUCONATE, 2-10% SULFUR, 0.2-1% VITAMIN A (106 IU), 2-6% METHIONINE, & INERT CARRIER SUCH AS CALCIUM CARBONATE OR FLOUR.

KOVAC L; CZECH PATENT 184924 09/15/78

DIETARY SUPPLEMENT & FOOD ADDITIVE; VITAMIN TABLETS

Sax, N.I. and R.J. Lewis, Sr. (eds.). Hawley's Condensed Chemical Dictionary. 11th ed. New York: Van Nostrand Reinhold Co., 1987., p. 1253

EXPTL USE: ZINC GLUCONATE ADDED TO SUBOPTIMAL DOSES OF ORTHO-GYNOL JELLY OR DELFEN CREAM IMPROVES VAGINAL CONTRACEPTIVE EFFICACY OF THESE PRODUCTS.

PMID:7214913 WILLIAMS WL; CONTRACEPTION 22 (6): 659-72 (1980)

EXPTL USE: TOXIC BLOOD LEAD LEVELS IN WORKERS DECR FROM 61.6 TO 46.0 UG/100 ML AFTER 24 WK TREATMENT WITH VITAMIN C & ZINC (2 G & 60 MG, DAILY). HEMOGLOBIN LEVELS INCR SIGNIFICANTLY & SERUM & WHOLE BLOOD COPPER LEVELS DECREASED FOLLOWING TREATMENT.

PAPAIOANNOU R ET AL; J ORTHOMOL PSYCHIATRY 7 (2): 94-106 (1978)

For more Therapeutic Uses (Complete) data for ZINC GLUCONATE (8 total), please visit the HSDB record page.

4.2 Drug Warning

A potential role for zinc in retarding the progression of age-related macular degeneration has not been proven. Zinc salts have not been found to be beneficial in the treatment of acute intermittent porphyria. /Zinc supplements/

USP Convention. USPDI - Drug Information for the Health Care Professional. 17th ed. Volume I. Rockville, MD: Convention, Inc., 1997. (Plus Updates)., p. 3020

Zinc injection that contains benzyl alcohol as a preservative should not be used in newborn and immature infants. The use of benzyl alcohol in neonates has been associated with a fatal toxic syndrome consisting of metabolic acidosis and CNS, respiratory, circulatory, and renal function impairment. /Zinc supplements/

USP Convention. USPDI - Drug Information for the Health Care Professional. 17th ed. Volume I. Rockville, MD: Convention, Inc., 1997. (Plus Updates)., p. 3020

4.3 Drug Indication

Zinc gluconate is mainly indicated in conditions like zinc deficiency, and can also be administered in adjunctive therapy as an alternative drug of choice in diarrhea.

5 Pharmacology and Biochemistry

5.1 Pharmacology

Zinc is an important mineral found in almost every cell in the human body. It promotes the activity of about 100 enzymes. Zinc deficiency is often associated with an increased risk of infection. When they are used to treat the common cold, zinc supplements may interfere with rhinovirus cleavage or adhesion and may play a role in protecting plasma membranes from microbial toxins and complement.

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Decreased Copper Ion Absorption [PE]; Copper Absorption Inhibitor [EPC]

5.3 ATC Code

A - Alimentary tract and metabolism

A12 - Mineral supplements

A12C - Other mineral supplements

A12CB - Zinc

A12CB02 - Zinc gluconate

5.4 Absorption, Distribution and Excretion

Absorption

Please refer to DrugBank entry [DB01593]

Route of Elimination

Feces and urine

Volume of Distribution

Stored primarily in skeletal muscle and bone.

Clearance

Please refer to DrugBank entry [DB01593]

5.5 Metabolism/Metabolites

Please refer to DrugBank entry [DB01593]

5.6 Biological Half-Life

280 days

5.7 Mechanism of Action

Although the mechanism of action is not completely known, zinc supplementation may be used to increase immunity against viruses or may interfere with the replication of certain viruses, such as the human papillomavirus (HPV).

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