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    Chemistry

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    Also known as: Zinc sulphate, 7733-02-0, Zinc sulfate anhydrous, Zincate, Zinc sulfate (1:1), Znso4
    Molecular Formula
    O4SZn
    Molecular Weight
    161.4  g/mol
    InChI Key
    NWONKYPBYAMBJT-UHFFFAOYSA-L
    FDA UNII
    0J6Z13X3WO
    Zinc Sulphate
    A compound given in the treatment of conditions associated with zinc deficiency such as acrodermatitis enteropathica. Externally, zinc sulfate is used as an astringent in lotions and eye drops. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)
    1 2D Structure

    Zinc Sulphate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    zinc;sulfate
    2.1.2 InChI
    InChI=1S/H2O4S.Zn/c1-5(2,3)4;/h(H2,1,2,3,4);/q;+2/p-2
    2.1.3 InChI Key
    NWONKYPBYAMBJT-UHFFFAOYSA-L
    2.1.4 Canonical SMILES
    [O-]S(=O)(=O)[O-].[Zn+2]
    2.2 Other Identifiers
    2.2.1 UNII
    0J6Z13X3WO
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Sulfate, Zinc

    2. Zinc Sulfate, Heptahydrate

    3. Zincteral

    2.3.2 Depositor-Supplied Synonyms

    1. Zinc Sulphate

    2. 7733-02-0

    3. Zinc Sulfate Anhydrous

    4. Zincate

    5. Zinc Sulfate (1:1)

    6. Znso4

    7. Sulfuric Acid, Zinc Salt (1:1)

    8. Sulfate De Zinc

    9. Zinc(ii) Sulfate

    10. Zinc Sulphate Anhydrous

    11. Zinc Sulfate, Anhydrous

    12. Zinc Sulphate, Anhydrous

    13. Zinc Sulfate (anhydrous)

    14. Zinc Sulfate Hydrate

    15. 0j6z13x3wo

    16. Chebi:35176

    17. Nsc-32677

    18. Nsc-135806

    19. Complexonat

    20. Medizinc

    21. Optised

    22. Orazinc

    23. Solvezinc

    24. Zinklet

    25. Neozin

    26. Visine-ac

    27. Zinci Sulfas

    28. Prefrin-z

    29. Zincum Sulfuricum

    30. Zink-gro

    31. Zinc Sulfate Solution

    32. Zinc Vitriol (van)

    33. Caswell No. 927

    34. White Vitriol (van)

    35. Zincsulphate

    36. Salvazinc

    37. Zinc;sulfate

    38. Nu-z

    39. Sulfuric Acid, Zinc Salt

    40. Zinc-200

    41. Sulfate De Zinc [french]

    42. Ccris 3664

    43. Sulfuric Acid Zinc Salt (van)

    44. Hsdb 1063

    45. Einecs 231-793-3

    46. Nsc 32677

    47. Epa Pesticide Chemical Code 089001

    48. Nsc 135806

    49. Unii-0j6z13x3wo

    50. Ai3-03967

    51. Sulfato De Cinc

    52. Zinc(ii)sulfate

    53. Sulfato De Zinco

    54. Solfato Di Zinco

    55. Zinc (as Sulfate)

    56. Zinc(2+) Sulfate

    57. Mfcd00011302

    58. Zinc (as Sulphate)

    59. Zinc Sulphate Hydrate

    60. Zinci Sulfas Monohydrate

    61. Zinc Suflate Monohydrate

    62. Zinc Sulfate, Unspecified

    63. Zinc Sulfate [mi]

    64. Zinc Sulphate Nanoparticles

    65. Ec 231-793-3

    66. Zinc Sulfate [hsdb]

    67. Zinc Sulfate, Unspecified Form

    68. Chembl1200929

    69. Dtxsid2040315

    70. Akos025295737

    71. Zinc Sulfate, 100mm Aqueous Solution

    72. Db09322

    73. Q204954

    74. J-010404

    2.4 Create Date
    2004-09-16
    3 Chemical and Physical Properties
    Molecular Weight 161.4 g/mol
    Molecular Formula O4SZn
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count0
    Exact Mass159.880871 g/mol
    Monoisotopic Mass159.880871 g/mol
    Topological Polar Surface Area88.6 Ų
    Heavy Atom Count6
    Formal Charge0
    Complexity62.2
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    Mesh Heading: Astringent

    National Library of Medicine, SIS; ChemIDplus Record for Zinc Sulfate. (7733-02-0). Available from, as of April 17, 2006: https://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp

    Dietary supplement ingredient in use before October 15, 1994 (Mineral and trace element) /Date of the Dietary Supplement Health and Education Act of 1994/..

    NNFA List of Dietary Supplement Ingredients In Use Before October 15, 1994. Available from, as of December 8, 2006: https://www.fda.gov/ohrms/dockets/dockets/05p0305/05p-0305-cr00001-03-NNFA-List-vol1.pdf

    MEDICATION (VET): Zinc sulfate, USP, applied topically in 10% aqueous solution, is highly effective in treatment of foot rot in sheep.

    Booth, N.H., L.E. McDonald (eds.). Veterinary Pharmacology and Therapeutics. 5th ed. Ames, Iowa: Iowa State University Press, 1982., p. 670

    MEDICATION (VET): Useful antiseptic astringent for ophthalmic use as aqueous solution or ointment (0.25-0.5%). Spraying sheep with 0.25% solution after shearing reduced incidence of infected wounds. 1% solutions have been used on granular vaginitis lesions of cows, posthitis of rams, and make excellent detergent, odorless, antiseptic egg wash. ... As white lotion ... on bruised, inflamed, pruritic skin areas on cows and horses.

    Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 669

    For more Therapeutic Uses (Complete) data for ZINC SULFATE (26 total), please visit the HSDB record page.

    4.2 Drug Warning

    ... Zinc sulfate often is an effective /emetic/, but potential hemolytic and renal toxicity is too great to recommend use ... .

    American Medical Association, AMA Department of Drugs. AMA Drug Evaluations. 5th ed. Chicago: American Medical Association, 1983., p. 489

    Thiazide diuretics have been found to increase urinary zinc excretion. /Zinc supplements/

    Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006.

    Large doses of zinc may inhibit copper absorption in the intestine; zinc supplements should be taken at least 2 hours after the administration of copper supplements. /Zinc supplements/

    Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006.

    Patients using zinc sulfate ophthalmic solutions should be advised to discontinue the drug and consult a physician if ocular pain or visual changes occur, they experience continued ocular redness or irritation, or the condition worsens or persists for more than 3 days.

    McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2006., p. 2761

    For more Drug Warnings (Complete) data for ZINC SULFATE (15 total), please visit the HSDB record page.

    4.3 Drug Indication

    This medication is a mineral used to treat or prevent low levels of zinc alone and together with oral rehydration therapy (ORT). It is also used as a topical astringent. Zinc Sulfate Injection, USP is indicated for use as a supplement to intravenous solutions given for TPN.

    Zinc sulfate is a common zinc supplement in parenteral nutrition.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Zinc has been identified as a cofactor for over 70 different enzymes, including alkaline phosphatase, lactic dehydrogenase and both RNA and DNA polymerase. Zinc facilitates wound healing, helps maintain normal growth rates, normal skin hydration and the senses of taste and smell.

    5.2 MeSH Pharmacological Classification

    Astringents

    Agents, usually topical, that cause the contraction of tissues for the control of bleeding or secretions. (See all compounds classified as Astringents.)

    5.3 FDA Pharmacological Classification
    5.3.1 Pharmacological Classes
    Decreased Copper Ion Absorption [PE]; Copper Absorption Inhibitor [EPC]
    5.4 ATC Code

    A - Alimentary tract and metabolism

    A12 - Mineral supplements

    A12C - Other mineral supplements

    A12CB - Zinc

    A12CB01 - Zinc sulfate

    B - Blood and blood forming organs

    B05 - Blood substitutes and perfusion solutions

    B05X - I.v. solution additives

    B05XA - Electrolyte solutions

    B05XA18 - Zinc sulfate

    5.5 Absorption, Distribution and Excretion

    Absorption

    Approximately 20 to 30% of dietary zinc is absorbed, primarily from the duodenum and ileum. The amount absorbed is dependent on the bioavailability from food. Zinc is the most bioavailable from red meat and oysters. Phytates may impair absorption by chelation and formation of insoluble complexes at an alkaline pH. After absorption, zinc is bound in the intestine to the protein metallothionein. Endogenous zinc can be reabsorbed in the ileum and colon, creating an enteropancreatic circulation of zinc.

    Route of Elimination

    Primarily fecal (approximately 90%); to a lesser extent in the urine and in perspiration.

    Volume of Distribution

    After absorption zinc is bound to protein metallothionein in the intestines. Zinc is widely distributed throughout the body. It is primarily stored in RBCs, WBCs, muscles, bones, Skin, Kidneys, Liver, Pancreas, retina, and prostate.

    The pharmacokinetics of zinc sulfate were compared with those of a new zinc pantothenate, in rabbits. Each salt was administered to rabbits at a dosage of 3.3 uCi of zinc-65/kg of body weight. The measured pharmacokinetics of the two compounds responded to a two compartment open model. The urinary elimination of the two salts was similar, as was their localization in the skin and fur, but Zn pantothenate was retained by the liver to a lesser extent than was zinc sulfate (ZnSO4).

    PMID:6520772 Guillard O et al; J Pharm Sci 73 (11): 1642-3 (1984)

    Absorption: 20% to 30%. Protein binding: 99%. Elimination: Through small bowel excretion.

    Lelkin, J.B., Paloucek, F.P., Poisoning & Toxicology Compendium. LEXI-COMP Inc. & American Pharmaceutical Association, Hudson, OH 1998., p. 573

    In women in different trimesters of pregnancy, the oral administration of 200 mg zinc sulfate per day resulted in an increase of serum zinc levels from 109.7 to 205.4 mg/dL. In the control group, serum zinc levels declined from 113.0 mg/dL in the first trimester to 83.8 in the third trimester.

    Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. 2:267

    ...An absorption half-life of 0.4 hr /was reported/ when 45 mg Zn2+ as zinc sulfate was administered once in gelatine capsules to 10 healthy young men. Serum concentrations were measured frequently during a total investigation time of 8 hours. A mean maximum concentration of 8.2 umol Zn2+/L serum was found after 2.3 hours (tmax). There is evidence of an enteral recirculation, the first rebound effect appeared after 1.4 hours during the absorption phase before tmax was reached, and exhibited mean reabsorption rates of 70% of the dose given. The subsequent ones (max. of 5) appeared at regular intervals of 1.2 hours with a decrease of the quantity reabsorbed.

    European Chemicals Bureau; EU Risk Assessment Report- Zinc sulphate, Vol.46 p.31 (2004). Available from, as of June 29, 2006: https://esis.jrc.ec.europa.eu/

    For more Absorption, Distribution and Excretion (Complete) data for ZINC SULFATE (14 total), please visit the HSDB record page.

    5.6 Biological Half-Life

    3 hours

    Half-life: 3 hours

    Lelkin, J.B., Paloucek, F.P., Poisoning & Toxicology Compendium. LEXI-COMP Inc. & American Pharmaceutical Association, Hudson, OH 1998., p. 573

    5.7 Mechanism of Action

    Zinc inhibits cAMP-induced, chloride-dependent fluid secretion by inhibiting basolateral potassium (K) channels, in in-vitro studies with rat ileum. This study has also shown the specificity of Zn to cAMP-activated K channels, because zinc did not block the calcium (Ca)-mediated K channels. As this study was not performed in Zn-deficient animals, it provides evidence that Zn is probably effective in the absence of Zn deficiency. Zinc also improves the absorption of water and electrolytes, improves regeneration of the intestinal epithelium, increases the levels of brush border enzymes, and enhances the immune response, allowing for a better clearance of the pathogens.

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CZF\/24-25\/002)(80DRUMS)","address":"P NO.26\/B, BIOTECH PARK, PHASE-3,","city":"MEDAK DIST, TELANGANA.","supplier":"HYMAVATHI LABORATORIES","supplierCountry":"INDIA","foreign_port":"CHITTAGONG","customer":"ZENITH PHARMACEUTICALS LIMITED","customerCountry":"BANGLADESH","quantity":"2000.00","actualQuantity":"2000","unit":"KGS","unitRateFc":"2.7","totalValueFC":"4805.4","currency":"USD","unitRateINR":201.89167499999999,"date":"18-Oct-2024","totalValueINR":"403783.35","totalValueInUsd":"4805.4","indian_port":"Hyderabad ICD","hs_no":"29420090","bill_no":"4921515","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BANGLADESH","selfForZScoreResived":"Pellets","supplierPort":"Hyderabad ICD","supplierAddress":"P NO.26\/B, BIOTECH PARK, PHASE-3,, MEDAK DIST, TELANGANA.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1731090600,"product":"PHARMACEUTICAL RAW MATERIAL-FERROUS FUMARTE 24 MG FOLIC ACID 500 MCG ZINC SULPHATE MONOHYDRATE 12 MG VITAMIN B6 5 MG","address":"A-3, SHIVSAGAR ESTATE,NORTH WING","city":"MUMBAI,MAHARASHTRA","supplier":"S K AGE ","supplierCountry":"INDIA","foreign_port":"TEMA","customer":"TO THE ORDER","customerCountry":"GHANA","quantity":"4600.00","actualQuantity":"4600","unit":"KGS","unitRateFc":"5.8","totalValueFC":"24570.5","currency":"USD","unitRateINR":450.75192608695653,"date":"09-Nov-2024","totalValueINR":"2073458.86","totalValueInUsd":"24570.5","indian_port":"JNPT","hs_no":"29420090","bill_no":"5476643","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"GHANA","selfForZScoreResived":"Pharma Grade","supplierPort":"JNPT","supplierAddress":"A-3, SHIVSAGAR ESTATE,NORTH WING, MUMBAI,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1736101800,"product":"BLENDED PELLETS OF CARBONYL IRON.ZINC SULPHATE MONOHYDRATE AND FOLIC ACID","address":"MIG-II,PLOT NO.46-47,FLAT NO.102,,","city":"HYDERABAD,TELANGANA","supplier":"KOLA PHARMA PRIVATE ","supplierCountry":"INDIA","foreign_port":"CHITTAGONG","customer":"M\/S.JANATA BANK LTD.,","customerCountry":"BANGLADESH","quantity":"2000.00","actualQuantity":"2000","unit":"KGS","unitRateFc":"3","totalValueFC":"5907.5","currency":"USD","unitRateINR":254.69999999999999,"date":"06-Jan-2025","totalValueINR":"509400","totalValueInUsd":"5907.5","indian_port":"Hyderabad ICD","hs_no":"29362290","bill_no":"7058842","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BANGLADESH","selfForZScoreResived":"Pellets","supplierPort":"Hyderabad ICD","supplierAddress":"MIG-II,PLOT NO.46-47,FLAT NO.102,,, HYDERABAD,TELANGANA","customerAddress":""}]
    19-Jan-2021
    06-Jan-2025
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    ABOUT THIS PAGE

    Looking for 7733-02-0 / Zinc Sulphate API manufacturers, exporters & distributors?

    Zinc Sulphate manufacturers, exporters & distributors 1

    34

    PharmaCompass offers a list of Zinc Sulphate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Zinc Sulphate manufacturer or Zinc Sulphate supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Zinc Sulphate manufacturer or Zinc Sulphate supplier.

    PharmaCompass also assists you with knowing the Zinc Sulphate API Price utilized in the formulation of products. Zinc Sulphate API Price is not always fixed or binding as the Zinc Sulphate Price is obtained through a variety of data sources. The Zinc Sulphate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Zinc Sulphate

    Synonyms

    7733-02-0, Zinc sulfate anhydrous, Zincate, Zinc sulfate (1:1), Znso4, Sulfuric acid, zinc salt (1:1)

    Cas Number

    7733-02-0

    Unique Ingredient Identifier (UNII)

    0J6Z13X3WO

    About Zinc Sulphate

    A compound given in the treatment of conditions associated with zinc deficiency such as acrodermatitis enteropathica. Externally, zinc sulfate is used as an astringent in lotions and eye drops. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)

    Zinc Sulphate Manufacturers

    A Zinc Sulphate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Zinc Sulphate, including repackagers and relabelers. The FDA regulates Zinc Sulphate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Zinc Sulphate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Zinc Sulphate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Zinc Sulphate Suppliers

    A Zinc Sulphate supplier is an individual or a company that provides Zinc Sulphate active pharmaceutical ingredient (API) or Zinc Sulphate finished formulations upon request. The Zinc Sulphate suppliers may include Zinc Sulphate API manufacturers, exporters, distributors and traders.

    click here to find a list of Zinc Sulphate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Zinc Sulphate USDMF

    A Zinc Sulphate DMF (Drug Master File) is a document detailing the whole manufacturing process of Zinc Sulphate active pharmaceutical ingredient (API) in detail. Different forms of Zinc Sulphate DMFs exist exist since differing nations have different regulations, such as Zinc Sulphate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Zinc Sulphate DMF submitted to regulatory agencies in the US is known as a USDMF. Zinc Sulphate USDMF includes data on Zinc Sulphate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Zinc Sulphate USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Zinc Sulphate suppliers with USDMF on PharmaCompass.

    Zinc Sulphate GMP

    Zinc Sulphate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Zinc Sulphate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Zinc Sulphate GMP manufacturer or Zinc Sulphate GMP API supplier for your needs.

    Zinc Sulphate CoA

    A Zinc Sulphate CoA (Certificate of Analysis) is a formal document that attests to Zinc Sulphate's compliance with Zinc Sulphate specifications and serves as a tool for batch-level quality control.

    Zinc Sulphate CoA mostly includes findings from lab analyses of a specific batch. For each Zinc Sulphate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Zinc Sulphate may be tested according to a variety of international standards, such as European Pharmacopoeia (Zinc Sulphate EP), Zinc Sulphate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Zinc Sulphate USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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