Zipalertinib

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

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Shanghai Hope Chem

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CLN-081

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- About The Company

Hope Chem is dedicated to manufacturing, marketing, and CMO service of Active Pharmaceutical Ingredients (APIs), Intermediates, and Specialty Chemicals since the year 2010. Currently, they have exclusive partnerships with mul...
Hope Chem is dedicated to manufacturing, marketing, and CMO service of Active Pharmaceutical Ingredients (APIs), Intermediates, and Specialty Chemicals since the year 2010. Currently, they have exclusive partnerships with multiple, state-of-the-art and GMP-compliant manufacturers in China and abroad to service our esteemed partners for competitive, long-term & stable supplies. The main products are APIs and intermediates of antiviral drug substances and anti-inflammatory, analgesic, and non-steroidal pharmaceuticals.

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Looking for 1661854-97-2 / CLN-081 API manufacturers, exporters & distributors?

PharmaCompass offers a list of CLN-081 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right CLN-081 manufacturer or CLN-081 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred CLN-081 manufacturer or CLN-081 supplier.

PharmaCompass also assists you with knowing the CLN-081 API Price utilized in the formulation of products. CLN-081 API Price is not always fixed or binding as the CLN-081 Price is obtained through a variety of data sources. The CLN-081 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

CLN-081

Synonyms

Tas6417, 1661854-97-2, Zipalertinib, Tas-6417, Zipalertinib [inn], T4ymu8tw9h

Cas Number

1661854-97-2

Unique Ingredient Identifier (UNII)

T4YMU8TW9H

About CLN-081

Zipalertinib is an orally available selective inhibitor of a broad spectrum of epidermal growth factor receptor (EGFR) mutations, including EGFR exon 20 insertion mutations (EGFR Ex20ins; Ex20ins mutations), with potential antineoplastic activity. CLN-081 is also active against other EGFR mutations including exon 19 deletions (exon19del), L858R, and T790M, as well as the less common G719X, L861Q and S768I mutations. Upon administration, zipalertinib specifically and covalently binds to and inhibits a variety of EGFR mutations, with particularly high selectivity against EGFR Ex20ins, which prevents EGFR mutant-mediated signaling and leads to cell death in EGFR mutant-expressing tumor cells. Compared to some other EGFR inhibitors, CLN-081 may have therapeutic benefits in tumors with EGFR Ex20ins, as most EGFR mutant-selective inhibitors are not active against EGFR Ex20ins. This agent shows minimal activity against wild-type EGFR (wt EGFR), and does not cause dose-limiting toxicities that occur during the use of non-selective EGFR inhibitors, which also inhibit wt EGFR. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization.

Zipalertinib Manufacturers

A Zipalertinib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Zipalertinib, including repackagers and relabelers. The FDA regulates Zipalertinib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Zipalertinib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Zipalertinib manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Zipalertinib Suppliers

A Zipalertinib supplier is an individual or a company that provides Zipalertinib active pharmaceutical ingredient (API) or Zipalertinib finished formulations upon request. The Zipalertinib suppliers may include Zipalertinib API manufacturers, exporters, distributors and traders.

click here to find a list of Zipalertinib suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Zipalertinib Manufacturers | Traders | Suppliers

We have 1 companies offering Zipalertinib

Get in contact with the supplier of your choice:

Shanghai Hope Chem

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.