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Chemistry

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Also known as: 1628260-79-6, Glpg-1690, Glpg1690, 2-((2-ethyl-6-(4-(2-(3-hydroxyazetidin-1-yl)-2-oxoethyl)piperazin-1-yl)-8-methylimidazo[1,2-a]pyridin-3-yl)(methyl)amino)-4-(4-fluorophenyl)thiazole-5-carbonitrile, Ziritaxestat [usan], Glpg-1690(ziritaxestat)
Molecular Formula
C30H33FN8O2S
Molecular Weight
588.7  g/mol
InChI Key
REQQVBGILUTQNN-UHFFFAOYSA-N
FDA UNII
I02418V13W

Ziritaxestat
Ziritaxestat is under investigation in clinical trial NCT03798366 (A Clinical Study to Test How Effective and Safe GLPG1690 is for Patients With Systemic Sclerosis).
1 2D Structure

Ziritaxestat

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[[2-ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]-methylamino]-4-(4-fluorophenyl)-1,3-thiazole-5-carbonitrile
2.1.2 InChI
InChI=1S/C30H33FN8O2S/c1-4-24-29(35(3)30-34-27(25(14-32)42-30)20-5-7-21(31)8-6-20)39-15-22(13-19(2)28(39)33-24)37-11-9-36(10-12-37)18-26(41)38-16-23(40)17-38/h5-8,13,15,23,40H,4,9-12,16-18H2,1-3H3
2.1.3 InChI Key
REQQVBGILUTQNN-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCC1=C(N2C=C(C=C(C2=N1)C)N3CCN(CC3)CC(=O)N4CC(C4)O)N(C)C5=NC(=C(S5)C#N)C6=CC=C(C=C6)F
2.2 Other Identifiers
2.2.1 UNII
I02418V13W
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-((2-ethyl-6-(4-(2-(3-hydroxyazetidin-1-yl)-2-oxoethyl)piperazin-1-yl)-8-methylimidazo(1,2-a)pyridin-3-yl)methylamino)-4-(4-fluorophenyl)thiazole-5-carbonitrile

2. Glpg1690

2.3.2 Depositor-Supplied Synonyms

1. 1628260-79-6

2. Glpg-1690

3. Glpg1690

4. 2-((2-ethyl-6-(4-(2-(3-hydroxyazetidin-1-yl)-2-oxoethyl)piperazin-1-yl)-8-methylimidazo[1,2-a]pyridin-3-yl)(methyl)amino)-4-(4-fluorophenyl)thiazole-5-carbonitrile

5. Ziritaxestat [usan]

6. Glpg-1690(ziritaxestat)

7. Chembl3828074

8. G451990

9. I02418v13w

10. G-451990

11. 2-[[2-ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]-methylamino]-4-(4-fluorophenyl)-1,3-thiazole-5-carbonitrile

12. 5-thiazolecarbonitrile, 2-((2-ethyl-6-(4-(2-(3-hydroxy-1-azetidinyl)-2-oxoethyl)-1-piperazinyl)-8-methylimidazo(1,2-a)pyridin-3-yl)methylamino)-4-(4-fluorophenyl)-

13. Ziritaxestatn

14. Ziritaxestat (usan/inn)

15. Ziritaxestat [inn]

16. Ziritaxestat (glpg1690)

17. Gtpl9561

18. Schembl16051264

19. Unii-i02418v13w

20. Bcp20895

21. Ex-a1646

22. Bdbm50187686

23. Mfcd31544330

24. S8895

25. Who 11017

26. Cs-7634

27. Db15403

28. Sb19736

29. Compound 11 [pmid: 28414242]

30. Ac-36149

31. Hy-101772

32. J3.652.431f

33. D11844

34. A902613

35. Q23075652

36. 2-((2-ethyl-6-(4-(2-(3-hydroxyazetidin-1-yl)-2-oxoethyl)piperazin-1-yl)-8-methylimidazo[1,2-a]pyridin-3-yl)(methyl)amino)-4-(4-fluorophenyl)thiazole-5-carbonitrile;glpg1690

37. 42-ethyl-14-fluoro-83-hydroxy-3,48-dimethyl-7-oxo-3-aza-4(3,6)-imidazo(1,2-a)pyridina-5(1,4)-piperazina-2(4,2)-(1,3)thiazola-8(1)-azetidina-1(1)-benzenaoctaphane-25-carbonitrile

2.4 Create Date
2015-02-13
3 Chemical and Physical Properties
Molecular Weight 588.7 g/mol
Molecular Formula C30H33FN8O2S
XLogP34.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count7
Exact Mass588.24312166 g/mol
Monoisotopic Mass588.24312166 g/mol
Topological Polar Surface Area133 Ų
Heavy Atom Count42
Formal Charge0
Complexity995
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Looking for 1628260-79-6 / Ziritaxestat API manufacturers, exporters & distributors?

Ziritaxestat manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Ziritaxestat API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Ziritaxestat manufacturer or Ziritaxestat supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Ziritaxestat manufacturer or Ziritaxestat supplier.

PharmaCompass also assists you with knowing the Ziritaxestat API Price utilized in the formulation of products. Ziritaxestat API Price is not always fixed or binding as the Ziritaxestat Price is obtained through a variety of data sources. The Ziritaxestat Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Ziritaxestat

Synonyms

1628260-79-6, Glpg-1690, Glpg1690, 2-((2-ethyl-6-(4-(2-(3-hydroxyazetidin-1-yl)-2-oxoethyl)piperazin-1-yl)-8-methylimidazo[1,2-a]pyridin-3-yl)(methyl)amino)-4-(4-fluorophenyl)thiazole-5-carbonitrile, Ziritaxestat [usan], Glpg-1690(ziritaxestat)

Cas Number

1628260-79-6

Unique Ingredient Identifier (UNII)

I02418V13W

About Ziritaxestat

Ziritaxestat is under investigation in clinical trial NCT03798366 (A Clinical Study to Test How Effective and Safe GLPG1690 is for Patients With Systemic Sclerosis).

Ziritaxestat Manufacturers

A Ziritaxestat manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ziritaxestat, including repackagers and relabelers. The FDA regulates Ziritaxestat manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ziritaxestat API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Ziritaxestat Suppliers

A Ziritaxestat supplier is an individual or a company that provides Ziritaxestat active pharmaceutical ingredient (API) or Ziritaxestat finished formulations upon request. The Ziritaxestat suppliers may include Ziritaxestat API manufacturers, exporters, distributors and traders.

Ziritaxestat GMP

Ziritaxestat Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Ziritaxestat GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ziritaxestat GMP manufacturer or Ziritaxestat GMP API supplier for your needs.

Ziritaxestat CoA

A Ziritaxestat CoA (Certificate of Analysis) is a formal document that attests to Ziritaxestat's compliance with Ziritaxestat specifications and serves as a tool for batch-level quality control.

Ziritaxestat CoA mostly includes findings from lab analyses of a specific batch. For each Ziritaxestat CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Ziritaxestat may be tested according to a variety of international standards, such as European Pharmacopoeia (Ziritaxestat EP), Ziritaxestat JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ziritaxestat USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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