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Zolazepam Hydrochloride

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ACTIVE PHARMA INGREDIENTS

1 NDC API, 1 VMF

1 NDC API
1 VMF

Synopsis

ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: Zolazepam hcl, 33754-49-3, Ci-716, 45sj093q1n, 4-(2-fluorophenyl)-1,3,8-trimethyl-6h-pyrazolo[3,4-e][1,4]diazepin-7-one;hydrochloride, 4-(o-fluorophenyl)-6,8-dihydro-1,3,8-trimethylpyrazolo(3,4-e)(1,4)diazepin-7(1h)-one monohydrochloride

Molecular Formula

C₁₅H₁₆ClFN₄O

Molecular Weight

322.76 g/mol

InChI Key

NJERAXSSDSHLGE-UHFFFAOYSA-N

FDA UNII

45SJ093Q1N

A pyrazolodiazepinone with pharmacological actions similar to ANTI-ANXIETY AGENTS. It is commonly used in combination with TILETAMINE to obtain immobilization and anesthesia in animals.

1 2D Structure

Zolazepam Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

4-(2-fluorophenyl)-1,3,8-trimethyl-6H-pyrazolo[3,4-e][1,4]diazepin-7-one;hydrochloride

2.1.2 InChI

InChI=1S/C15H15FN4O.ClH/c1-9-13-14(10-6-4-5-7-11(10)16)17-8-12(21)19(2)15(13)20(3)18-9;/h4-7H,8H2,1-3H3;1H

2.1.3 InChI Key

NJERAXSSDSHLGE-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1=NN(C2=C1C(=NCC(=O)N2C)C3=CC=CC=C3F)C.Cl

2.2 Other Identifiers

2.2.1 UNII

45SJ093Q1N

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Ci 716

2. Ci-716

3. Ci716

4. Flupyrazapon

5. Flupyrazopon

6. Hydrochloride, Zolazepam

7. Zolasepam

8. Zolazepam

2.3.2 Depositor-Supplied Synonyms

1. Zolazepam Hcl

2. 33754-49-3

3. Ci-716

4. 45sj093q1n

5. 4-(2-fluorophenyl)-1,3,8-trimethyl-6h-pyrazolo[3,4-e][1,4]diazepin-7-one;hydrochloride

6. 4-(o-fluorophenyl)-6,8-dihydro-1,3,8-trimethylpyrazolo(3,4-e)(1,4)diazepin-7(1h)-one Monohydrochloride

7. Pyrazolo(3,4-e)(1,4)diazepin-7(1h)-one, 4-(2-fluorophenyl)-6,8-dihydro-1,3,8-trimethyl-, Monohydrochloride

8. Unii-45sj093q1n

9. Zolazepam Hydrochloride [usan]

10. Einecs 251-668-7

11. Zolazepam Hydrochloride [usan:usp]

12. Schembl73002

13. Zolazepam Hydrochloride (usp)

14. Chembl2107559

15. Dtxsid00955349

16. Zolazepam Hydrochloride(500 Mg)

17. Zolazepam Hydrochloride [mi]

18. Zolazepam Hydrochloride [usp-rs]

19. Zolazepam Hydrochloride [green Book]

20. Ft-0775057

21. Zolazepam Hydrochloride [usp Impurity]

22. D06377

23. Zolazepam Hydrochloride [usp Monograph]

24. Q27258863

25. 4-(2-fluorophenyl)-1,3,8-trimethyl-6h-pyrazolo[3,4-e][1,4]diazepin-7-one,hydrochloride

26. 4-(2-fluorophenyl)-1,3,8-trimethyl-6,8-dihydropyrazolo[3,4-e][1,4]diazepin-7(1h)-one--hydrogen Chloride (1/1)

27. 4-(2-fluorophenyl)-6,8-dihydro-1,3,8-trimethylpyrazolo(3,4-e)(1,4)diazepin-7(1h)-one Monohydrochloride

28. 42551-17-7

29. Pyrazolo(3,4-e)(1,4)diazepin-7(1h)-one, 4-(2-fluorophenyl)-6,8-dihydro-1,3,8-trimethyl-, Hydrochloride

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₁₅H₁₆ClFN₄O
Molecular Weight	322.76 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	1
Exact Mass	322.0996670 g/mol
Monoisotopic Mass	322.0996670 g/mol
Topological Polar Surface Area	50.5 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	455
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Anti-Anxiety Agents

Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)

GABA Modulators

Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here. (See all compounds classified as GABA Modulators.)

NDC API