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Zoliflodacin

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$ API Reference Price

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Synopsis

ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: 1620458-09-4, Azd0914, Azd-0914, Zoliflodacin [usan], Etx0914, Etx-0914

Molecular Formula

C₂₂H₂₂FN₅O₇

Molecular Weight

487.4 g/mol

InChI Key

ZSWMIFNWDQEXDT-ZESJGQACSA-N

FDA UNII

FWL2263R77

Zoliflodacin has been used in trials studying the basic science and treatment of Gonorrhoea.

1 2D Structure

Zoliflodacin

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(4'R,6'S,7'S)-17'-fluoro-4',6'-dimethyl-13'-[(4S)-4-methyl-2-oxo-1,3-oxazolidin-3-yl]spiro[1,3-diazinane-5,8'-5,15-dioxa-2,14-diazatetracyclo[8.7.0.02,7.012,16]heptadeca-1(17),10,12(16),13-tetraene]-2,4,6-trione

2.1.2 InChI

InChI=1S/C22H22FN5O7/c1-8-7-33-21(32)28(8)17-12-4-11-5-22(18(29)24-20(31)25-19(22)30)16-10(3)34-9(2)6-27(16)14(11)13(23)15(12)35-26-17/h4,8-10,16H,5-7H2,1-3H3,(H2,24,25,29,30,31)/t8-,9+,10-,16+/m0/s1

2.1.3 InChI Key

ZSWMIFNWDQEXDT-ZESJGQACSA-N

2.1.4 Canonical SMILES

CC1CN2C(C(O1)C)C3(CC4=CC5=C(C(=C42)F)ON=C5N6C(COC6=O)C)C(=O)NC(=O)NC3=O

2.1.5 Isomeric SMILES

C[C@@H]1CN2[C@H]([C@@H](O1)C)C3(CC4=CC5=C(C(=C42)F)ON=C5N6[C@H](COC6=O)C)C(=O)NC(=O)NC3=O

2.2 Other Identifiers

2.2.1 UNII

FWL2263R77

2.3 Synonyms

2.3.1 MeSH Synonyms

1. (2r,4s,4as)-11-fluoro-2,4-dimethyl-8-((4s)-4-methyl-2-oxo-1,3-oxazolidin-3-yl)-1,2,4,4a-tetrahydro-2'h,6h-spiro((1,2)-oxazolo(4,5-g)(1,4)oxazino(4,3-a)quinoline-5,5'-pyrimidine)-2',4',6'(1'h,3'h)-trione

2. Azd-0914

3. Azd0914

4. Etx-0914

5. Etx0914

2.3.2 Depositor-Supplied Synonyms

1. 1620458-09-4

2. Azd0914

3. Azd-0914

4. Zoliflodacin [usan]

5. Etx0914

6. Etx-0914

7. Fwl2263r77

8. (2r,4s,4as)-11-fluoro-2,4-dimethyl-8-((4s)-4-methyl-2-oxo-1,3-oxazolidin-3-yl)-1,2,4,4a-tetrahydro-2'h,6h-spiro((1,2)-oxazolo(4,5-g)(1,4)oxazino(4,3-a)quinoline-5,5'-pyrimidine)-2',4',6'(1'h,3'h)-trione

9. Unii-fwl2263r77

10. Zoliflodacin(azd0914)

11. Zoliflodacin (usan/inn)

12. Zoliflodacin [inn]

13. Zoliflodacin [who-dd]

14. Azd 0914 - Bio-x

15. Chembl3544978

16. Schembl15879500

17. Gtpl10875

18. Azd0914etx0914

19. Ext0914

20. Bdbm139376

21. Dtxsid101028418

22. Azd 0914

23. Ex-a2620

24. Ext-0914

25. Etx0914; Azd0914; Zoliflodacin

26. Db12817

27. Ac-35757

28. Ba164192

29. Hy-17647

30. Cs-0016917

31. D11726

32. Us8889671, 5

33. Q27278240

34. (2r,4s,4as)-11-fluoro-2,4-dimethyl-8-((s)-4-methyl-2-oxooxazolidin-3-yl)-1,2,4,4a-tetrahydro-2'h,6h-spiro[isoxazolo[4,5-g][1,4]oxazino[4,3-a]quinoline-5,5'-pyrimidine]-2',4',6'(1'h,3'h)-trione

35. (2r,4s,4as)-11-fluoro-2,4-dimethyl-8-((s)-4-methyl-2-oxooxazolidin-3-yl)-2,4,4a,6-tetrahydro-1h,1'h-spiro[isoxazolo[4,5-g][1,4]oxazino[4,3-a]quinoline-5,5'-pyrimidine]-2',4',6'(3'h)-trione

36. (4'r,6's,7's)-17'-fluoro-4',6'-dimethyl-13'-[(4s)-4-methyl-2-oxo-1,3-oxazolidin-3-yl]spiro[1,3-diazinane-5,8'-5,15-dioxa-2,14-diazatetracyclo[8.7.0.02,7.012,16]heptadeca-1(17),10,12(16),13-tetraene]-2,4,6-trione

37. (7s,11r,13s)-3-((4s)-2-oxo-4-methyltetrahydrooxazole-3-yl)-9-fluoro-11,13-dimethyl-8,7-(ethanoxymethano)-7,8,1',2',3',4'-hexahydrospiro[isoxazolo[4,5-g]quinoline-6(5h),5'(6'h)-pyrimidine]-2',4',6'-trione

38. Spiro(isoxazolo(4,5-g)(1,4)oxazino(4,3-a)quinoline-5(6h),5'(2'h)-pyrimidine)-2',4',6'(1'h,3'h)-trione, 11-fluoro-1,2,4,4a-tetrahydro-2,4-dimethyl-8-((4s)-4-methyl-2-oxo-3-oxazolidinyl)-, (2r,4s,4as)-

2.4 Create Date

2014-08-04

3 Chemical and Physical Properties

Molecular Formula	C₂₂H₂₂FN₅O₇
Molecular Weight	487.4 g/mol
XLogP3	1.3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	1
Exact Mass	487.15032622 g/mol
Monoisotopic Mass	487.15032622 g/mol
Topological Polar Surface Area	143 Å²
Heavy Atom Count	35
Formal Charge	0
Complexity	962
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Indication

Treatment of gonococcal infection

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Topoisomerase II Inhibitors

Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II. (See all compounds classified as Topoisomerase II Inhibitors.)

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Zoliflodacin Manufacturers

A Zoliflodacin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Zoliflodacin, including repackagers and relabelers. The FDA regulates Zoliflodacin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Zoliflodacin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Zoliflodacin Suppliers

A Zoliflodacin supplier is an individual or a company that provides Zoliflodacin active pharmaceutical ingredient (API) or Zoliflodacin finished formulations upon request. The Zoliflodacin suppliers may include Zoliflodacin API manufacturers, exporters, distributors and traders.

Zoliflodacin GMP

Zoliflodacin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Zoliflodacin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Zoliflodacin GMP manufacturer or Zoliflodacin GMP API supplier for your needs.

Zoliflodacin CoA

A Zoliflodacin CoA (Certificate of Analysis) is a formal document that attests to Zoliflodacin's compliance with Zoliflodacin specifications and serves as a tool for batch-level quality control.

Zoliflodacin CoA mostly includes findings from lab analyses of a specific batch. For each Zoliflodacin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Zoliflodacin may be tested according to a variety of international standards, such as European Pharmacopoeia (Zoliflodacin EP), Zoliflodacin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Zoliflodacin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.