Find Zotiraciclib manufacturers, exporters & distributors on PharmaCompass

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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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API Suppliers

API Suppliers

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USDMF

US DMFs Filed

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CEP/COS

CEP/COS Certifications

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JDMF

JDMFs Filed

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EU WC

EU WC

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KDMF

KDMF

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NDC API

NDC API

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VMF

NDC API

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Listed Suppliers

Other Suppliers

0INTERMEDIATES

REF. STANDARDS OR IMPURITIES

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EDQM

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USP

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JP

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Others

FINISHED DOSAGE FORMULATIONS

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FDA Orange Book

FDA (Orange Book)

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Europe

Europe

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Canada

Canada

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Australia

Australia

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South Africa

South Africa

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Listed Dossiers

Listed Dossiers

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

PATENTS & EXCLUSIVITIES

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US Patents

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US Exclusivities

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Health Canada Patents

API REF. PRICE (USD/KG)

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GLOBAL SALES INFORMATION

US Medicaid

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Chemistry

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Also known as: Sb1317, Tg02, Tg-02, 1204918-72-8, Sb-1317, 937270-47-8
Molecular Formula
C23H24N4O
Molecular Weight
372.5  g/mol
InChI Key
VXBAJLGYBMTJCY-NSCUHMNNSA-N
FDA UNII
40D08182TT

Zotiraciclib
Zotiraciclib is under investigation in clinical trial NCT02942264 (Zotiraciclib (TG02) Plus Dose-dense or Metronomic Temozolomide Followed by Randomized Phase II Trial of Zotiraciclib (TG02) Plus Temozolomide Versus Temozolomide Alone in Adults With Recurrent Anaplastic Astrocytoma and Glioblastoma).
1 2D Structure

Zotiraciclib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(16E)-14-methyl-20-oxa-5,7,14,27-tetrazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2(27),3,5,8,10,12(26),16,21,23-decaene
2.1.2 InChI
InChI=1S/C23H24N4O/c1-27-13-3-2-4-14-28-21-10-6-8-19(16-21)22-11-12-24-23(26-22)25-20-9-5-7-18(15-20)17-27/h2-3,5-12,15-16H,4,13-14,17H2,1H3,(H,24,25,26)/b3-2+
2.1.3 InChI Key
VXBAJLGYBMTJCY-NSCUHMNNSA-N
2.1.4 Canonical SMILES
CN1CC=CCCOC2=CC=CC(=C2)C3=NC(=NC=C3)NC4=CC=CC(=C4)C1
2.1.5 Isomeric SMILES
CN1C/C=C/CCOC2=CC=CC(=C2)C3=NC(=NC=C3)NC4=CC=CC(=C4)C1
2.2 Other Identifiers
2.2.1 UNII
40D08182TT
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene

2. Sb1317

3. Tg02

2.3.2 Depositor-Supplied Synonyms

1. Sb1317

2. Tg02

3. Tg-02

4. 1204918-72-8

5. Sb-1317

6. 937270-47-8

7. Sb-1317 Free Base

8. (e/z)-zotiraciclib

9. Zotiraciclib [usan]

10. Ex 45

11. Ex45

12. Chembl1944698

13. 40d08182tt

14. Tg02 (sb1317)

15. Zotiraciclib (usan)

16. 20-oxa-5,7,14,27-tetraazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2,4,6(27),8,10,12(26),16,21,23-decaene, 14-methyl-

17. Tg02 (double Bond E)

18. Zotiraciclib [inn]

19. Schembl823947

20. Tg02 [who-dd]

21. Zotiraciclib [who-dd]

22. Gtpl9095

23. Schembl2298965

24. Schembl17595943

25. Unii-40d08182tt

26. Ex-a239

27. Dtxsid601337151

28. 14-methyl-20-oxa-5,7,14,27-tetraazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2,4,6(27),8,10,12(26),16,21,23-decaene

29. Bcp07033

30. Bdbm50363196

31. Mfcd22124499

32. Nsc762673

33. Who 11186

34. Zinc68251500

35. Akos032950000

36. Sb1317(tg-02)

37. Cs-0884

38. Nsc-762673

39. Sb 1317

40. Compound 26h [pmid: 22148278]

41. Ncgc00378999-05

42. 14-methyl-20-oxa-5,7,14,27-tetraazatetracyclo [19.3.1.12,6.18,12]heptacosa-1(25),2,4,6(27),8,10,12(26),16,21,23-decaene

43. Ac-33131

44. Ac-35951

45. Bs-14812

46. Bs167349

47. Hy-15166

48. D11599

49. Q27088971

50. (e)-6-methyl-12-oxa-3,6-diaza-2(4,2)-pyrimidina-1,4(1,3)-dibenzenacyclododecaphan-8-ene

51. (6e)-9-methyl-3-oxa-9,12-diaza-1(4,2)-pyrimidina-2,11(1,3)-dibenzenacyclododecaphan-6-ene

52. 14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene

53. 20-oxa-5,7,14,27-tetraazatetracyclo(19.3.1.12,6.18,12)heptacosa-1(25),2,4,6(27),8,10,12(26),16,21,23-decaene, 14-methyl-, (16e)-

2.4 Create Date
2007-10-01
3 Chemical and Physical Properties
Molecular Weight 372.5 g/mol
Molecular Formula C23H24N4O
XLogP34.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count0
Exact Mass372.19501140 g/mol
Monoisotopic Mass372.19501140 g/mol
Topological Polar Surface Area50.3 Ų
Heavy Atom Count28
Formal Charge0
Complexity499
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Looking for 1204918-72-8 / Zotiraciclib API manufacturers, exporters & distributors?

Zotiraciclib manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Zotiraciclib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Zotiraciclib manufacturer or Zotiraciclib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Zotiraciclib manufacturer or Zotiraciclib supplier.

PharmaCompass also assists you with knowing the Zotiraciclib API Price utilized in the formulation of products. Zotiraciclib API Price is not always fixed or binding as the Zotiraciclib Price is obtained through a variety of data sources. The Zotiraciclib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Zotiraciclib

Synonyms

Sb1317, Tg02, Tg-02, 1204918-72-8, Sb-1317, 937270-47-8

Cas Number

1204918-72-8

Unique Ingredient Identifier (UNII)

40D08182TT

About Zotiraciclib

Zotiraciclib is under investigation in clinical trial NCT02942264 (Zotiraciclib (TG02) Plus Dose-dense or Metronomic Temozolomide Followed by Randomized Phase II Trial of Zotiraciclib (TG02) Plus Temozolomide Versus Temozolomide Alone in Adults With Recurrent Anaplastic Astrocytoma and Glioblastoma).

Zotiraciclib Manufacturers

A Zotiraciclib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Zotiraciclib, including repackagers and relabelers. The FDA regulates Zotiraciclib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Zotiraciclib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Zotiraciclib Suppliers

A Zotiraciclib supplier is an individual or a company that provides Zotiraciclib active pharmaceutical ingredient (API) or Zotiraciclib finished formulations upon request. The Zotiraciclib suppliers may include Zotiraciclib API manufacturers, exporters, distributors and traders.

Zotiraciclib GMP

Zotiraciclib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Zotiraciclib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Zotiraciclib GMP manufacturer or Zotiraciclib GMP API supplier for your needs.

Zotiraciclib CoA

A Zotiraciclib CoA (Certificate of Analysis) is a formal document that attests to Zotiraciclib's compliance with Zotiraciclib specifications and serves as a tool for batch-level quality control.

Zotiraciclib CoA mostly includes findings from lab analyses of a specific batch. For each Zotiraciclib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Zotiraciclib may be tested according to a variety of international standards, such as European Pharmacopoeia (Zotiraciclib EP), Zotiraciclib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Zotiraciclib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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