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Chemistry

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Also known as: 85721-05-7, 2-[4-[(3z)-3-(2-chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]ethyl acetate, 349s2zhf05, Clopenthixol acetate ester, Clopixol acuphase, Clopixol-acuphase
Molecular Formula
C24H27ClN2O2S
Molecular Weight
443.0  g/mol
InChI Key
OXAUOBQMCDIVPQ-IOXNKQMXSA-N
FDA UNII
349S2ZHF05

Zuclopenthixol Acetate
1 2D Structure

Zuclopenthixol Acetate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[4-[(3Z)-3-(2-chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]ethyl acetate
2.1.2 InChI
InChI=1S/C24H27ClN2O2S/c1-18(28)29-16-15-27-13-11-26(12-14-27)10-4-6-20-21-5-2-3-7-23(21)30-24-9-8-19(25)17-22(20)24/h2-3,5-9,17H,4,10-16H2,1H3/b20-6-
2.1.3 InChI Key
OXAUOBQMCDIVPQ-IOXNKQMXSA-N
2.1.4 Canonical SMILES
CC(=O)OCCN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl
2.1.5 Isomeric SMILES
CC(=O)OCCN1CCN(CC1)CC/C=C\2/C3=CC=CC=C3SC4=C2C=C(C=C4)Cl
2.2 Other Identifiers
2.2.1 UNII
349S2ZHF05
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (z)-4-(3-(2-chlorothioxanthen-9-ylidene)propyl)-1-piperazineethanol Acetate

2. Clopenthixol Acetate Ester

3. Clopixol-acuphase

2.3.2 Depositor-Supplied Synonyms

1. 85721-05-7

2. 2-[4-[(3z)-3-(2-chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]ethyl Acetate

3. 349s2zhf05

4. Clopenthixol Acetate Ester

5. Clopixol Acuphase

6. Clopixol-acuphase

7. Cisordinol-acutard (tn)

8. Einecs 288-415-5

9. Unii-349s2zhf05

10. Schembl1651216

11. Dtxsid00235032

12. Chebi:135722

13. Zinc30691716

14. (z)-4-(3-(2-chlorothioxanthen-9-ylidene)propyl)-1-piperazineethanol Acetate

15. Akos015841102

16. Zuclopenthixol Acetate [mart.]

17. Zuclopenthixol Acetate [who-dd]

18. (z)-4-(3-(2-chloro-9h-thioxanthen-9-ylidene)propyl)piperazine-1-ethyl Acetate

19. D08691

20. Q27256348

21. 4-[3-[(z)-2-chloro-9h-thioxanthen-9-ylidene]propyl]-1-piperazineethanol Acetate

2.4 Create Date
2006-04-28
3 Chemical and Physical Properties
Molecular Weight 443.0 g/mol
Molecular Formula C24H27ClN2O2S
XLogP34.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Exact Mass442.1481770 g/mol
Monoisotopic Mass442.1481770 g/mol
Topological Polar Surface Area58.1 Ų
Heavy Atom Count30
Formal Charge0
Complexity608
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antipsychotic Agents

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)


API SUPPLIERS

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01

R L Fine Chem

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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01

Compamed
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Zuclopenthixol Acetate

About the Company : Established in 1984, R L Fine Chem Pvt. Ltd. is one of the fastest growing API companies, with a leadership position in several APIs such as antihistamines, antidepressants and mus...

Established in 1984, R L Fine Chem Pvt. Ltd. is one of the fastest growing API companies, with a leadership position in several APIs such as antihistamines, antidepressants and muscle relaxants. Acquired by private equity groups in 2016, it is one of India’s leading manufacturers of psychotropic substances. It supplies over 60 APIs to customers in more than 62 countries from FDA and EU-approved locations. R L Fine Chem is a technology-driven company with a focus on the in-house manufacture of key intermediates for our APIs. The company currently operates out of four facilities in the Indian states of Karnataka and Andhra Pradesh.
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API Reference Price

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[{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1719858600,"product":"PHARMACEUTICAL BULK DRUG - ZUCLOPENTHIXOL ACETATE\/BP","address":"RAY HOUSE, HIG 2000,,MOTHER DIARY","city":"BANGALORE,KARNATAKA","supplier":"R L FINE CHEM","supplierCountry":"INDIA","foreign_port":"DHAKA","customer":"TO THE ORDER OF","customerCountry":"BANGLADESH","quantity":"0.50","actualQuantity":"0.5","unit":"KGS","unitRateFc":"15000","totalValueFC":"6981.8","currency":"USD","unitRateINR":1167232.52,"date":"02-Jul-2024","totalValueINR":"583616.26","totalValueInUsd":"6981.8","indian_port":"Bangalore Air","hs_no":"29420090","bill_no":"2125585","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BANGLADESH","selfForZScoreResived":"Pharma Grade","supplierPort":"Bangalore Air","supplierAddress":"RAY HOUSE, HIG 2000,,MOTHER DIARY, BANGALORE,KARNATAKA","customerAddress":""}]
02-Jul-2024
02-Jul-2024
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FDF Dossiers

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01

H. Lundbeck AS

Denmark
Compamed
Not Confirmed
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H. Lundbeck AS

Denmark
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Compamed
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zuklopentixolacetat

Brand Name : Cisordinol-Acutard

Dosage Form : SOLUTION FOR INJECTION

Dosage Strength : 50 MG / ML

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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02

H. Lundbeck AS

Denmark
Compamed
Not Confirmed
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H. Lundbeck AS

Denmark
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Compamed
Not Confirmed

Zuclopenthixol Acetate

Brand Name : Clopixol Acuphase

Dosage Form :

Dosage Strength : 1 Ampoule Im 50 Mg 1 Ml  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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03

H. Lundbeck AS

Denmark
Compamed
Not Confirmed
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H. Lundbeck AS

Denmark
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Compamed
Not Confirmed

Zuclopenthixol Acetate

Brand Name : Cisordinol-Acutard

Dosage Form : Injection fluid, resolution

Dosage Strength : 50 mg/ml

Packaging : Ampoule

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Norway

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04

H. Lundbeck AS

Denmark
Compamed
Not Confirmed
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H. Lundbeck AS

Denmark
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Compamed
Not Confirmed

ZUCLOPENTHIXOL ACETATE

Brand Name : CLOPIXOL-ACUPHASE 50MG/ML

Dosage Form : SOLUTION

Dosage Strength : 50MG/ML

Packaging : 5X1ML/5X2ML

Approval Date :

Application Number : 2230405

Regulatory Info : Prescription

Registration Country : Canada

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05

H. Lundbeck AS

Denmark
Compamed
Not Confirmed
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H. Lundbeck AS

Denmark
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Compamed
Not Confirmed

Zuclopenthixol acetate

Brand Name : Clopixol Acuphase 50 mg/ml

Dosage Form : INJ

Dosage Strength : 50mg/ml

Packaging : 1X1mg/ml

Approval Date :

Application Number :

Regulatory Info : Originator

Registration Country : South Africa

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06

Compamed
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Compamed
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zuklopentixolacetat

Brand Name : Clopixol-Acutard

Dosage Form : SOLUTION FOR INJECTION

Dosage Strength : 50 MG / ML

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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07

Compamed
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Compamed
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zuklopentixolacetat

Brand Name : Clopixol-Acutard

Dosage Form : SOLUTION FOR INJECTION

Dosage Strength : 50 MG / ML

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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08

Compamed
Not Confirmed
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Compamed
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zuklopentixolacetat

Brand Name : Clopixol-Acutard

Dosage Form : SOLUTION FOR INJECTION

Dosage Strength : 50 MG / ML

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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09

Country
Compamed
Not Confirmed
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Country
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Compamed
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zuklopentixolacetat

Brand Name : Clopixol-Acutard

Dosage Form : SOLUTION FOR INJECTION

Dosage Strength : 50 MG / ML

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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10

Country
Compamed
Not Confirmed
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Country
arrow
Compamed
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zuklopentixolacetat

Brand Name : Clopixol-Acutard

Dosage Form : SOLUTION FOR INJECTION

Dosage Strength : 50 MG / ML

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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