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    About

    Zhejiang Huahai Pharmaceuticals Co., Ltd.was initially founded in 1989, and the company's stock was successfully listed in Shanghai Stock Exchange in March, 2003. Huahai Pharmaceuticals, a large scaled modern pharmaceutical group that integrates fomulations, APIs(Active Pharmaceutical Ingredients) and intermediates, is developing both domestic and international markets, and performing parallel development of science, industry...
    Zhejiang Huahai Pharmaceuticals Co., Ltd.was initially founded in 1989, and the company's stock was successfully listed in Shanghai Stock Exchange in March, 2003. Huahai Pharmaceuticals, a large scaled modern pharmaceutical group that integrates fomulations, APIs(Active Pharmaceutical Ingredients) and intermediates, is developing both domestic and international markets, and performing parallel development of science, industry and commerce. With a total asset of 1,900 million yuan, the company has 11branches (subsidiaries) in the United States, Shanghai, Hangzhou, and Linhai.

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    Zhejiang Huahai PharmaceuticalChina Flag
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    Xunqiao, Linhai, Zhejiang 317024
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    +86-576-85016116
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    https://en.huahaipharm.com:443/
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    INTERVIEW #SpeakPharma

    [Sponsored by another company]
    “Translational Pharmaceutics, our flagship platform for drug development, empowers our clients with unparalleled flexibility”

    “Translational Pharmaceutics, our flagship platform for drug development, empowers our clients with unparalleled flexibility”

    This week, SpeakPharma interviews Denise Sutton, Chief Operating Officer and Site Head at Quotient Sciences’ Nottingham facility in the UK. Quotient Sciences is a drug development and manufacturing accelerator that offers the innovative Translational Pharmaceutics platform to support customers in overcoming drug development challenges. Sutton has been with the company for over 25 years. In this interview, she provides insights into the evolution of Quotient Sciences’ Nottingham facility and discusses how the organization has transformed from a small 10-bed clinic to a comprehensive drug development campus with six GMP suites. She also shares her perspective on the company’s unique approach to integrating drug development services. HIGHLIGHTS// evolution of Quotient Sciences’ Nottingham facility/ unique approach to integrating drug development services How has the Nottingham site transformed from when it was founded, to what it is today? Initially, we were a small company with fewer than 50 employees, a 10-bed clinic, and a single lab. Over 90 percent of our work focused on gamma scintigraphic imaging (a diagnostic test that creates images of the body’s internal organs and tissues using gamma rays). Due to the short half-life radionuclides we used to label dosage forms, every product we manufactured had a limited time to be dosed. At the end of 1999, we moved our headquarters to a purpose-built, two-storey facility—now known as Trent House on our now much larger Nottingham campus. We built three good manufacturing practice (GMP) suites on the top floor and three clinical wards on the bottom floor. These were very early days that marked the start of our Translational Pharmaceutics platform. We continued to expand the range of scintigraphy applications we offered in response to changing customer requirements until, in 2008, when we approached the MHRA (UK’s Medicines and Healthcare products Regulatory Agency) with a new request. We asked if it might be possible to work at the same pace as we did in our scintigraphic imaging studies, but do so for conventional drug development, without the radiolabel. We explored the application of ICH Q8 Quality by Design (QbD) guidelines to introduce a compositional design space into the CMC section of our regulatory dossier. This officially created a methodology for applying the Translational Pharmaceutics platform, and we haven't looked back since. Today, we have expanded substantially. Our Nottingham site is a campus of five buildings. We have development and analytical labs, six GMP suites, six clinical wards with a total of 85 beds (where we conduct healthy volunteer phase 1 clinical studies), and many talented colleagues covering our spectrum of CRO and CDMO services. HIGHLIGHTS// officially created a methodology for applying the Translational Pharmaceutics platform/ development and analytical labs/ six GMP suites   How is Translational Pharmaceutics applied to drug development programs? We apply Translational Pharmaceutics across three core applications: first-in-human clinical studies, drug product optimization programs through rapid formulation development and clinical testing, and as a part of human ADME (absorption, distribution, metabolism, and excretion) programs. No matter how a client chooses to work with us to apply Translational Pharmaceutics, the benefits of using a single organization and project management team to integrate services lets our clients remain in control and one step ahead of the emerging data that impacts the success of their molecule. Over all these years, our flagship Translational Pharmaceutics platform for drug development has remained unchanged in the way it empowers our customers and offers them unparalleled flexibility. HIGHLIGHTS// three core applications/ benefits of using a single organization/ clients remain in control   What would you say are the key strengths of Quotient Sciences’ Nottingham site? How do you support customer programs? Nowhere else would a single project manager oversee such a broad spectrum of activities, let alone be expected to ensure seamless, timely progression across functions that in any other company (i.e. at other CDMOs or CROs) would be delivered through multiple operating areas or through the use of a combination of third-party vendors. The project managers do face challenges. But by working with the project team, they are able to anticipate, avoid, and mitigate any impact whenever necessary. We know that time is incredibly valuable for our customers. A project Gantt chart is our project management team’s guiding light. I believe our project management team is truly world-leading – they communicate well, show great compassion, and lead with integrity. I’m super proud of our high-performing, supportive, cross-functional teams that support our customers when they trust their molecules to us, and work collaboratively to deliver the best possible service. After 25 years at Quotient, I continue to really enjoy going to work. I am indebted to various colleagues for helping me continue to feel this way. HIGHLIGHTS// project management team is truly world-leading/ high-performing, supportive, cross-functional teams/ 25 years at Quotient  

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    Chinese FDA-registered generic facilities gain steam, India maintains lead with 396 facilities

    Chinese FDA-registered generic facilities gain steam, India maintains lead with 396 facilities

    Every year, the US Food and Drug Administration (FDA) publishes the user fee amounts it will collect from manufacturers of pharmaceuticals, generic drugs, biosimilars and medical devices in the coming financial year. The fee for fiscal year 2025 under the Generic Drug User Fee Act (GDUFA) was published on July 31, 2024.The GDUFA, established in 2012, authorizes FDA to assess and collect fees from drug manufacturers to expedite the delivery of safe, high-quality, and affordable generic drugs to the American public.The FDA’s facility payments list under GDUFA reveals that as of November 14, 2024, 1,397 facilities had paid their registration fees for financial year 2025. Of these facilities, 707 or 50.6 percent are active pharmaceutical ingredients (API) facilities, 405 or 29 percent are finished dosage forms (FDF) facilities, 69 (4.9 percent) are facilities that produce both APIs and FDFs, and 216 (15.5 percent) are contract manufacturing services (CMO) sites.Teva Pharmaceuticals, with 29 facility registrations, led the list of companies, followed by Aurobindo Pharma, Sun Pharma, and Dr. Reddy's Laboratories. Fiscal year Facility Registrations 2016 1,425 2017 1,442 2018 1,269 2019 1,286 2020 1,300 2021 1,340 2022 1,385 2023 1,394 2024 1,447 2025 1,397  Generic Drug Facilities Registered with the US FDA for FY2025 (Free Excel Available)India continues to lead with 396 facilities, US and China follow India maintains its dominance in total facility registrations with the FDA, registering 396 facilities for FY2025. This includes 214 API facilities, 135 FDF facilities, 21 facilities engaged in both API and FDF activities, and 26 CMO facilities.The United States holds the second position with 328 facilities, while China strengthened its third position with 197 facilities.With 214 API facilities, India continues to have the largest share of API manufacturing sites, outmatching the combined total of China (128) and the US (83), which together account for 211 facilities. Among European manufacturers, Italy leads with 59 API manufacturing sites, followed by Spain (30) and Germany (25).The US has maintained its lead in FDF facilities with 143 sites, followed closely by India with 135 sites and China with 45 sites. Country API FDF Both CMO Total India 214 135 21 26 396 US 83 143 13 89 328 China 128 45 12 12 197 Italy 59 3 2 19 83 Germany 25 4 1 15 45 Spain 30 9 1 4 44 Canada 7 17   13 37 Taiwan 9 6 5 4 24 Switzerland 15 4   4 23 France 16     6 22 Japan 18   1   19 United Kingdom 12 1   2 15 Mexico 9 1   1 11 Ireland 5 5   1 11   Generic Drug Facilities Registered with the US FDA for FY2025 (Free Excel Available) GDUFA III user fee rates increase across categories for FY25The GDUFA, which was reauthorized on September 30, 2022 (as GDUFA III), continues with provisions that will last until September 30, 2027. In July 2024, the FDA published updated user fee rates for FY2025.The facility fees have seen increases across all categories. API facility fees increased by 3 percent for domestic sites (to US$ 41,580) and 2 percent for foreign sites (to US$ 56,580). FDF facility fees rose by 5 percent for both domestic (to US$ 231,952) and foreign sites (to US$ 246,952). CMO facility fees increased by 5 percent for domestic sites (to US$ 55,668) and 4 percent for foreign sites (to US$ 70,668).Additionally, the fee for large-, medium- and small-sized drug applicants has increased by over 9 percent, compared to the 7 percent increase seen in 2023. Generic Drug Facilities Registered with the US FDA for FY2025 (Free Excel Available) China leads new facility registrations as FDA records 41 new units in FY25Out of the total 1,397 facilities registered for FY2025, 41 were new registrations (going by Facility FDA Establishment Identifier numbers). China led the way with 13 new facilities, followed closely by India with 11 new facilities, while the US secured the third position with eight new facilities.The new registrations included 15 API facilities, 13 CMO facilities, 12 FDF facilities, and one facility engaged in both API and FDF activities. Chinese companies dominated the new FDF registrations with six facilities: Chengdu Shuode Pharma, Chengdu Suncadia Medicine, Cipla (Jiangsu), GE Healthcare (Shanghai), Luoxin Aurovitas Pharma (Chengdu), and Zhejiang Xianju Pharma.India added two new FDF facilities through Eugia Steriles and Zydus Pharma. Malaysia registered two FDF facilities through Novugen Pharma and Novugen Oncology, while Turkey’s Insud Pharma subsidiary Exeltis and US’ RK Pharma registered one FDF facility each.The 13 new CMO facilities included, Acme Generics, Emcure, Esjay Pharma, Fordoz Pharma, Fourrts Laboratories, Laboratoires KABS, PharmaMax, Quality Packaging Specialists International, Ritsa Pharma, Shanghai Aucyun Pharma, Sichuan Huiyu Pharma, Taejoon Pharm, and Tubilux Pharma.In the API category, the 15 new registrations included Acharya Chemicals, Hainan Poly Pharma, CBL Patras, EUROAPI, Hybio Pharma, Medilux Laboratories, Metrochem API, Purolite, Chengdu Easton Biopharma, Sionc Pharma, Smithfield Bioscience, Xttrium Laboratories, Zhejiang Hengkang Pharma, Moehs Iberica and Shilpa Pharma. Armstrong Pharmaceuticals registered the sole facility for both APIs and FDFs.So far, 92 facilities have not renewed their registration. Among these was a facility owned by Sandoz subsidiary Eon Labs in Wilson, North Carolina (US), which is permanently closed. In fact, the geographical distribution of non-renewals shows that 30 facilities were from the US, while India and China accounted for 14 and nine non-renewals respectively. Generic Drug Facilities Registered with the US FDA for FY2025 (Free Excel Available) Our viewThe FY 2025 GDUFA facility registration data indicates a continued strong presence of Indian manufacturers in the US generic drug market, particularly in API production. However, China's leadership in new facility registrations, especially in FDF manufacturing, suggests that the global generic drug supply chain landscape may evolve considerably in the coming years. 
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    21 Nov 2024
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    Pfizer tabs controversial Chinese firm Huahai to make Paxlovid
    Pfizer tabs controversial Chinese firm Huahai to make Paxlovid

    24 Aug 2022

    // Kevin Dunleavy FIERCEPHARMA

    https://www.fiercepharma.com/manufacturing/paxlovid-production-pfizer-partners-chinese-company-huahai-which-coming-fda-ban

    Kevin Dunleavy FIERCEPHARMA
    24 Aug 2022
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    Pfizer Picks China Firm Involved in Drug Recall for Covid Pill
    Pfizer Picks China Firm Involved in Drug Recall for Covid Pill

    23 Aug 2022

    // BLOOMBERG

    https://www.bnnbloomberg.ca/pfizer-picks-china-firm-involved-in-drug-recall-for-covid-pill-1.1809083

    BLOOMBERG
    23 Aug 2022
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    Biocon-Viatris, AstraZeneca, Huhai and more—Fierce Pharma Asia
    Biocon-Viatris, AstraZeneca, Huhai and more—Fierce Pharma Asia

    19 Nov 2021

    // Angus Liu FIERCEPHARMA

    https://www.fiercepharma.com/pharma-asia/biocon-viatris-insulin-biosimilar-astrazeneca-china-performance-huahai-fda-warning-lift

    Angus Liu FIERCEPHARMA
    19 Nov 2021
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    Valsartan recall protagonist comes off FDA warning letter
    Valsartan recall protagonist comes off FDA warning letter

    16 Nov 2021

    // Angus Liu FIERCEPHARMA

    https://www.fiercepharma.com/manufacturing/3-years-valsartan-recall-zhejiang-huahai-china-drug-manufacturer-fda-warning-letter

    Angus Liu FIERCEPHARMA
    16 Nov 2021
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    Zhejiang Huahai Pharma Receives FDA Warning Letter
    Zhejiang Huahai Pharma Receives FDA Warning Letter

    11 Nov 2021

    // FDA

    https://www.pharmacompass.com/pdf/news/zhejiang-huahai-pharma-receives-fda-warning-letter-1637048144.pdf

    FDA
    11 Nov 2021
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    EMA, FDA begin reviewing heartburn medicines for carcinogen
    EMA, FDA begin reviewing heartburn medicines for carcinogen

    17 Sep 2019

    // Zachary Brennan ENDPTS

    https://endpts.com/ema-fda-begin-reviewing-heartburn-medicines-for-carcinogen/

    Zachary Brennan ENDPTS
    17 Sep 2019
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    Zhejiang Huahai Pharmaceutical

    Registration Number : 304MF10122

    Registrant's Address : Xunqiao, Linhai, Zhejiang 317024, China

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    Registration Number : 227MF10237

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    Registration Number : 227MF10268

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    Registration Number : 303MF10128

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    Zhejiang Huahai Pharmaceutical

    Registration Number : 228MF10003

    Registrant's Address : Xunqiao, Linhai, Zhejiang 317024, China

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    Latest Date of Registration : 2016-01-08

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    Zhejiang Huahai Pharmaceutical

    Registration Number : 306MF10094

    Registrant's Address : Xunqiao, Linhai, Zhejiang 317024, China

    Initial Date of Registration : 2024-07-11

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    Zhejiang Huahai Pharmaceutical

    Registration Number : 301MF10091

    Registrant's Address : Xunqiao, Linhai, Zhejiang 317024, China

    Initial Date of Registration : 2019-11-15

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    Zhejiang Huahai Pharmaceutical

    Registration Number : 219MF10148

    Registrant's Address : Xunqiao, Linhai, Zhejiang 317024, China

    Initial Date of Registration : 2007-04-27

    Latest Date of Registration : 2019-05-21

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    Zhejiang Huahai Pharmaceutical

    Registration Number : 303MF10094

    Registrant's Address : Xunqiao, Linhai, Zhejiang 317024, China

    Initial Date of Registration : 2021-06-15

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    Type : GMP Certificates

    Number : 2007/HMP/PT...

    EudraGMDP Key : 8767

    Country : China

    Issue Date :

    Post Code : 317024

    NCA Ref : A058 3020 84...

    City : LINHAI, PROVINCE ZHEJIA...

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    Type : GMP Certificates

    Number : ES/137/11

    EudraGMDP Key : 11558

    Country : China

    Issue Date :

    Post Code : 317024

    NCA Ref : 405

    City : Zhejiang China

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    Type : GMP Certificates

    Number : ES/123/11

    EudraGMDP Key : 11560

    Country : China

    Issue Date :

    Post Code : 317024

    NCA Ref : 404

    City : Zhejiang China

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    Zhejiang Huahai Pharmaceutical

    Type : GMP Certificates

    Number : ES/033/12

    EudraGMDP Key : 11560

    Country : China

    Issue Date :

    Post Code : 317024

    NCA Ref : 404

    City : Zhejiang China

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    Type : GMP Certificates

    Number : ES/029/12

    EudraGMDP Key : 11560

    Country : China

    Issue Date :

    Post Code : 317024

    NCA Ref : 404

    City : Zhejiang China

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    Type : GMP Certificates

    Number : ES/030/12

    EudraGMDP Key : 11560

    Country : China

    Issue Date :

    Post Code : 317024

    NCA Ref : 404

    City : Zhejiang China

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    Zhejiang Huahai Pharmaceutical

    Type : GMP Certificates

    Number : ES/031/12

    EudraGMDP Key : 11560

    Country : China

    Issue Date :

    Post Code : 317024

    NCA Ref : 404

    City : Zhejiang China

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    Zhejiang Huahai Pharmaceutical

    Type : GMP Certificates

    Number : DE_HH_01_GM...

    EudraGMDP Key : 26737

    Country : China

    Issue Date :

    Post Code : 317016

    NCA Ref : 20742

    City : Zhejiang

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    GMP Certified

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    Antibody Engineering
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    GMP Certified

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    Antibody Engineering
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    Zhejiang Huahai Pharmaceutical

    Type : GMP Certificates

    Number : DE_HH_01_GM...

    EudraGMDP Key : 30108

    Country : China

    Issue Date : 2016-02-04

    Post Code : 317024

    NCA Ref : 00021462

    City : Zhejiang

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    GMP Certified

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    Antibody Engineering
    Not Confirmed
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    GMP Certified

    EU
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    Antibody Engineering
    Not Confirmed

    Zhejiang Huahai Pharmaceutical

    Type : GMP Certificates

    Number : DE_HH_01_GM...

    EudraGMDP Key : 30108

    Country : China

    Issue Date : 2015-09-01

    Post Code : 317024

    NCA Ref : 00021462

    City : Zhejiang

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    Contact Zhejiang Huahai Pharmaceutical and get a quotation

    Zhejiang Huahai Pharmaceutical is a supplier offers 107 products (APIs, Excipients or Intermediates).

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