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Also known as: 121808-62-6, (r)-3-((s)-5-oxopyrrolidine-2-carbonyl)thiazolidine-4-carboxylic acid, Pidotomod, Pidotimod [inn], Pgt/1a, Pilimod
Molecular Formula
C9H12N2O4S
Molecular Weight
244.27  g/mol
InChI Key
UUTKICFRNVKFRG-WDSKDSINSA-N
FDA UNII
785363R681

Pidotimod
Pidotimod is a synthetic dipeptide with immunomodulatory properties.
1 2D Structure

Pidotimod

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(4R)-3-[(2S)-5-oxopyrrolidine-2-carbonyl]-1,3-thiazolidine-4-carboxylic acid
2.1.2 InChI
InChI=1S/C9H12N2O4S/c12-7-2-1-5(10-7)8(13)11-4-16-3-6(11)9(14)15/h5-6H,1-4H2,(H,10,12)(H,14,15)/t5-,6-/m0/s1
2.1.3 InChI Key
UUTKICFRNVKFRG-WDSKDSINSA-N
2.1.4 Canonical SMILES
C1CC(=O)NC1C(=O)N2CSCC2C(=O)O
2.1.5 Isomeric SMILES
C1CC(=O)N[C@@H]1C(=O)N2CSC[C@H]2C(=O)O
2.2 Other Identifiers
2.2.1 UNII
785363R681
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 3-((5-oxo-2-pyrrolidinyl)carbonyl)-4-thiazolidinecarboxylic Acid

2. 3-pyroglutamylthiazolidine-4-carboxylic Acid

3. 3-pyroglutamylthiazolidine-4-carboxylic Acid, (r-(r*,s*))-isomer

4. Adimod

5. Pgt-1a

2.3.2 Depositor-Supplied Synonyms

1. 121808-62-6

2. (r)-3-((s)-5-oxopyrrolidine-2-carbonyl)thiazolidine-4-carboxylic Acid

3. Pidotomod

4. Pidotimod [inn]

5. Pgt/1a

6. Pilimod

7. Nsc-759841

8. (r)-3-((s)-5-oxoprolyl)-4-thiazolidinecarboxylic Acid

9. Pidotimod (inn)

10. (4r)-3-[(2s)-5-oxopyrrolidine-2-carbonyl]-1,3-thiazolidine-4-carboxylic Acid

11. Ncgc00160516-01

12. Polimod

13. (4r)-3-{[(2s)-5-oxopyrrolidin-2-yl]carbonyl}-1,3-thiazolidine-4-carboxylic Acid

14. 785363r681

15. Pidotimodum

16. Pigitil

17. Pidotimodum [inn-latin]

18. 4-thiazolidinecarboxylic Acid, 3-[[(2s)-5-oxo-2-pyrrolidinyl]carbonyl]-, (4r)-

19. Smr000466390

20. Ccris 7271

21. Brn 6636310

22. Onaka

23. Thymodolic Acid

24. Axil

25. Timodolic Acid

26. Pilimod (tn)

27. Pidotimod - Bio-x

28. Unii-785363r681

29. Pidotimod [mi]

30. Pidotimod [mart.]

31. (r-(r*,s*))-3-((5-oxo-2-pyrrolidinyl)carbonyl)-4-thiazolidinecarboxylic Acid

32. Pidotimod [who-dd]

33. (4r)-3-[[(2s)-5-oxo-2-pyrrolidinyl]carbonyl]-4-thiazolidinecarboxylic Acid

34. (r)-3-((s)-(5-oxo-2-pyrrolidinyl)carbonyl)-thiazolidin-4-carbonsaeure [german]

35. Dsstox_cid_26199

36. Dsstox_rid_81430

37. Dsstox_gsid_46199

38. Mls000759528

39. Mls001032108

40. Mls001216453

41. Mls001423953

42. Schembl138407

43. Chembl1488165

44. Dtxsid0046199

45. Pidotimod, >=98% (hplc)

46. Chebi:94618

47. Hms2051c04

48. Hms2231m03

49. Hms3715h06

50. Pharmakon1600-01502322

51. Bcp05222

52. Hy-b0944

53. Zinc3781245

54. Tox21_111865

55. Mfcd00867583

56. Nsc759841

57. S3106

58. (r)-3-((s)-(5-oxo-2-pyrrolidinyl)carbonyl)-thiazolidin-4-carbonsaeure

59. Akos015896354

60. Ac-3493

61. Am90280

62. Ccg-100832

63. Db11364

64. Ks-5229

65. Nc00082

66. Nsc 759841

67. (r)-3-[[(s)-5-oxo-2-pyrrolidinyl]carbonyl]-1,3-thiazolidine-4-carboxylic Acid

68. 4-thiazolidinecarboxylic Acid, 3-((5-oxo-2-pyrrolidinyl)carbonyl)-, (r-(r*,s*))-

69. Ncgc00160516-03

70. Bp164260

71. Cas-121808-62-6

72. P2147

73. Sw197462-2

74. D07261

75. Ab00639966-08

76. Ab00639966_10

77. Ab00639966_11

78. 808p626

79. A804790

80. J-502193

81. Q3902720

82. (4r)-3-[(2s)-5-oxopyrrolidine-2-carbonyl]thiazolidine-4-carboxylic Acid;pidotimod

83. (4r)-3-[[(2s)-5-oxo-2-pyrrolidinyl]carbonyl]thiazolidine-4-carboxylic Acid

84. (4r)-3-[oxo-[(2s)-5-oxo-2-pyrrolidinyl]methyl]-4-thiazolidinecarboxylic Acid

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 244.27 g/mol
Molecular Formula C9H12N2O4S
XLogP3-0.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass244.05177804 g/mol
Monoisotopic Mass244.05177804 g/mol
Topological Polar Surface Area112 Ų
Heavy Atom Count16
Formal Charge0
Complexity346
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

For use as immunostimulant therapy for treatment of cell-mediated immunosuppression with respiratory or urinary infections.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Pidotimod modulates the immune system to induce an immune response against bacterial or viral pathogens


5.2 MeSH Pharmacological Classification

Adjuvants, Immunologic

Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. (See all compounds classified as Adjuvants, Immunologic.)


Immunologic Factors

Biologically active substances whose activities affect or play a role in the functioning of the immune system. (See all compounds classified as Immunologic Factors.)


5.3 ATC Code

L - Antineoplastic and immunomodulating agents

L03 - Immunostimulants

L03A - Immunostimulants

L03AX - Other immunostimulants

L03AX05 - Pidotimod


5.4 Absorption, Distribution and Excretion

Absorption

Bioavailability of 45%.


Route of Elimination

95% of intravenous dose is eliminated in the urine as the parent compound.


5.5 Biological Half-Life

Half life of 4 h.


5.6 Mechanism of Action

Pidotimod inhibits tumor necrosis factor (TNF-) induced increases in extracellular signal-related kinase (ERK) phosphorylation. It also increases nuclear factor B (NFB) expression and translocation to the nucleus. It is these to modulatory effects on ERK and NFB signalling which are thought to produce the increase in toll-like receptor expression seen with pidotimod. Pidotimod increase maturation of dendritic cells responsible for presenting antigens to naive Th-cells. It also appears to result in a greater population these cells diiferentiating to Th1 cells which are believed to mediate the immune response to pathogens like bacteria and viruses. Lastly, pidotimod appears to increase antigen-specific antibody titer and cytotoxic response with antigen exposure. The precise mechanism and timeline of events leading to these effects is unknown.


API Reference Price

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31-Dec-2024
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API | Excipient name

Pidotimod

Synonyms

121808-62-6, (r)-3-((s)-5-oxopyrrolidine-2-carbonyl)thiazolidine-4-carboxylic acid, Pidotomod, Pidotimod [inn], Pgt/1a, Pilimod

Cas Number

121808-62-6

Unique Ingredient Identifier (UNII)

785363R681

About Pidotimod

Pidotimod is a synthetic dipeptide with immunomodulatory properties.

Axil Manufacturers

A Axil manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Axil, including repackagers and relabelers. The FDA regulates Axil manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Axil API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Axil manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Axil Suppliers

A Axil supplier is an individual or a company that provides Axil active pharmaceutical ingredient (API) or Axil finished formulations upon request. The Axil suppliers may include Axil API manufacturers, exporters, distributors and traders.

click here to find a list of Axil suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Axil KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Axil Drug Master File in Korea (Axil KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Axil. The MFDS reviews the Axil KDMF as part of the drug registration process and uses the information provided in the Axil KDMF to evaluate the safety and efficacy of the drug.

After submitting a Axil KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Axil API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Axil suppliers with KDMF on PharmaCompass.

Axil NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Axil as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Axil API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Axil as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Axil and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Axil NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Axil suppliers with NDC on PharmaCompass.

Axil GMP

Axil Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Axil GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Axil GMP manufacturer or Axil GMP API supplier for your needs.

Axil CoA

A Axil CoA (Certificate of Analysis) is a formal document that attests to Axil's compliance with Axil specifications and serves as a tool for batch-level quality control.

Axil CoA mostly includes findings from lab analyses of a specific batch. For each Axil CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Axil may be tested according to a variety of international standards, such as European Pharmacopoeia (Axil EP), Axil JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Axil USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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