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Chemistry

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Also known as: 77-73-6, Cyclopentadiene dimer, Bicyclopentadiene, Biscyclopentadiene, Dicyklopentadien, Dimer cyklopentadienu
Molecular Formula
C10H12
Molecular Weight
132.20  g/mol
InChI Key
HECLRDQVFMWTQS-UHFFFAOYSA-N

Dicyclopentadiene
1 2D Structure

Dicyclopentadiene

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
tricyclo[5.2.1.02,6]deca-3,8-diene
2.1.2 InChI
InChI=1S/C10H12/c1-2-9-7-4-5-8(6-7)10(9)3-1/h1-2,4-5,7-10H,3,6H2
2.1.3 InChI Key
HECLRDQVFMWTQS-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1C=CC2C1C3CC2C=C3
2.2 Synonyms
2.2.1 Depositor-Supplied Synonyms

1. 77-73-6

2. Cyclopentadiene Dimer

3. Bicyclopentadiene

4. Biscyclopentadiene

5. Dicyklopentadien

6. Dimer Cyklopentadienu

7. 4,7-methano-1h-indene, 3a,4,7,7a-tetrahydro-

8. Dcpd

9. 3a,4,7,7a-tetrahydro-4,7-methanoindene

10. 3a,4,7,7a-tetrahydro-1h-4,7-methanoindene

11. Nsc 7352

12. 4,7-methanoindene, 3a,4,7,7a-tetrahydro-

13. 4,7-methano-3a,4,7,7a-tetrahydroindene

14. 4,7-methano-1h-indene, 3a,4,7,7a-tetrahydro-, Homopolymer

15. Chebi:34695

16. Endo-dicyclopentadiene

17. 25038-78-2

18. Prometa Xp 100

19. Ncgc00090776-02

20. Tricyclo[5.2.1.02,6]deca-3,8-diene

21. Tricyclo[5.2.1.0(2,6)]deca-3,8-diene

22. Dicyklopentadien [czech]

23. Dimer Cyklopentadienu [czech]

24. Ccris 4790

25. Hsdb 321

26. 1,3-cpd

27. 3a,4,7,7a-tetrahydro-4,7-methano-1h-indene

28. 1755-01-7

29. Alpha-dicyclopentadiene (endo Form)

30. Einecs 201-052-9

31. Un2048

32. Tricyclo(5.2.1.0)-3,8-decadiene

33. Dicyclopentadiene Homopolymer

34. Brn 1904092

35. Nsc-7352

36. Ai3-03386

37. Un 2048

38. 1, Dimer

39. Tricyclo[5.2.1.0<2,6>]deca-3,8-diene

40. Dsstox_cid_5023

41. Ec 201-052-9

42. Dsstox_rid_77632

43. Dsstox_gsid_25023

44. 2-05-00-00391 (beilstein Handbook Reference)

45. Mls001055376

46. Chembl1570502

47. Dtxsid5025023

48. Nsc7352

49. (3a.alpha.,4.alpha.,7.alpha.,7a.alpha.)-3a,4,7,7a-tetrahydro-4,7-methano-1h-indene

50. Hms3039j06

51. Wln: L C555 A Du Iutj

52. 933-60-8

53. Tox21_400017

54. Stl445669

55. Akos000119974

56. Akos022186108

57. 3a,7,7a-tetrahydro-4,7-methanoindene

58. 4,7-methano-1h-indene, 3a,4,7,7a-tetrahydro-, (3a.alpha.,4.alpha.,7.alpha.,7a.alpha.)-

59. Cas-77-73-6

60. Ncgc00090776-01

61. Ncgc00090776-03

62. Ac-16096

63. Smr000677942

64. Dicyclopentadiene Contains Bht As Stabilizer

65. D0443

66. Dicyclopentadiene [un2048] [flammable Liquid]

67. Q419053

68. J-520256

69. Q-200967

70. F0001-1975

2.3 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 132.20 g/mol
Molecular Formula C10H12
XLogP32.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count0
Rotatable Bond Count0
Exact Mass132.093900383 g/mol
Monoisotopic Mass132.093900383 g/mol
Topological Polar Surface Area0 Ų
Heavy Atom Count10
Formal Charge0
Complexity212
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count4
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 Absorption, Distribution and Excretion

In general, although some dicyclopentadiene can be exhaled unchanged, most of that absorbed is hydroxylated in the liver, undergoes glucuronide conjugation, and is excreted in the urine.

Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V2 39


/MILK/ When given by oral administration to lactating cows urine and feces contained 86% of administered dose with only trace amounts being secreted in milk. Some may have been eliminated in gaseous form. Compound was extensively absorbed from GI tract.

PMID:7459454 Wayne G, Oehler DD; Bull Environ Contam Toxicol 24 (5): 662-70 (1980)


Dicyclopentadiene is predicted to be rapidly absorbed and distributed following any route of administration. It is extensively absorbed from the GI tract.

Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V4 203


The substance can be absorbed into the body by inhalation and by ingestion.

IPCS, CEC; International Chemical Safety Card on Dicyclopentadiene. (October 2005). Available from, as of October 03, 2006: https://www.inchem.org/documents/icsc/icsc/eics0873.htm


Tetramethylenephosphonate derivatives of norborane (TPNB) and dicyclopentadiene (TPDCPD) were shown to readily form stable chelates with (99m)Tc that had high and selective bone uptake. The skeletal uptake and blood clearance properties of (99m)Tc-TPNB were similar to (99m)Tc-MDP in both rats and rabbits. This suggests additional studies to further evaluate (99m)Tc-TPNB or perhaps other large-organic based multidentate phosphonate ligands as potential bone imaging agents is warranted.

PMID:3771236 Volkert WA et al; Int J Rad Appl Instrum B 13 (1): 31-7 (1986)


4.2 Metabolism/Metabolites

When given by oral admin to lactating cows, metabolites were present in urine mainly in form of glucuronide conjugates. It is suggested that epoxidation of double bonds occurred, followed by hydrolysis of epoxides to diols & conjugation with glucuronic acid.

Wayne G, Oehler DD; Bull Environ Contam Toxicol 24 (5): 662-70 (1980)


... Urinary metabolites of dicyclopentadiene were not identified specifically, but analysis by thin layer chromatography indicated that the urine of mice and rats each had seven components. Six components were found in the urine of dogs. The Rf values of these components were similar; therefore, common metabolites were indicated in all three species. Only 1-3% of the radioactivity was attributed to nonmetabolized (14)carbon-dicyclopentadiene in all three species. When the urine from all species was subjected to enzymatic hydrolysis by glusulase (beta glucuronidase and sulfatase) and extracted, was recovered in the extract, indicating the presence of urine conjugates.

USEPA; Health and Environmental Effects Profile for Cyclopentadiene and Dicyclopentadiene p.16 (1987) ECAO-CIN-G012


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Dicyclopentadiene manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Dicyclopentadiene API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Dicyclopentadiene manufacturer or Dicyclopentadiene supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Dicyclopentadiene manufacturer or Dicyclopentadiene supplier.

PharmaCompass also assists you with knowing the Dicyclopentadiene API Price utilized in the formulation of products. Dicyclopentadiene API Price is not always fixed or binding as the Dicyclopentadiene Price is obtained through a variety of data sources. The Dicyclopentadiene Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Dicyclopentadiene

Synonyms

77-73-6, Cyclopentadiene dimer, Bicyclopentadiene, Biscyclopentadiene, Dicyklopentadien, Dimer cyklopentadienu

Cas Number

77-73-6

Dicyclopentadiene Manufacturers

A Dicyclopentadiene manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Dicyclopentadiene, including repackagers and relabelers. The FDA regulates Dicyclopentadiene manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Dicyclopentadiene API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Dicyclopentadiene manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Dicyclopentadiene Suppliers

A Dicyclopentadiene supplier is an individual or a company that provides Dicyclopentadiene active pharmaceutical ingredient (API) or Dicyclopentadiene finished formulations upon request. The Dicyclopentadiene suppliers may include Dicyclopentadiene API manufacturers, exporters, distributors and traders.

click here to find a list of Dicyclopentadiene suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Dicyclopentadiene GMP

Dicyclopentadiene Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Dicyclopentadiene GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Dicyclopentadiene GMP manufacturer or Dicyclopentadiene GMP API supplier for your needs.

Dicyclopentadiene CoA

A Dicyclopentadiene CoA (Certificate of Analysis) is a formal document that attests to Dicyclopentadiene's compliance with Dicyclopentadiene specifications and serves as a tool for batch-level quality control.

Dicyclopentadiene CoA mostly includes findings from lab analyses of a specific batch. For each Dicyclopentadiene CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Dicyclopentadiene may be tested according to a variety of international standards, such as European Pharmacopoeia (Dicyclopentadiene EP), Dicyclopentadiene JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Dicyclopentadiene USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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