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Also known as: 3736-81-0, Dichlofurazol, Furentomin, Histomibal, Diloxanid furoate, 4-(2,2-dichloro-n-methylacetamido)phenyl furan-2-carboxylate
Molecular Formula
C14H11Cl2NO4
Molecular Weight
328.1  g/mol
InChI Key
BDYYDXJSHYEDGB-UHFFFAOYSA-N
FDA UNII
YP4N72IW34

Diloxanide Furoate
1 2D Structure

Diloxanide Furoate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[4-[(2,2-dichloroacetyl)-methylamino]phenyl] furan-2-carboxylate
2.1.2 InChI
InChI=1S/C14H11Cl2NO4/c1-17(13(18)12(15)16)9-4-6-10(7-5-9)21-14(19)11-3-2-8-20-11/h2-8,12H,1H3
2.1.3 InChI Key
BDYYDXJSHYEDGB-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN(C1=CC=C(C=C1)OC(=O)C2=CC=CO2)C(=O)C(Cl)Cl
2.2 Other Identifiers
2.2.1 UNII
YP4N72IW34
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2,2-dichloro-4'-hydroxy-n-methylacetanilide 2-furoate

2. 2-furamide

3. Diloxanide

4. Entamide Furoate

5. Furamide

2.3.2 Depositor-Supplied Synonyms

1. 3736-81-0

2. Dichlofurazol

3. Furentomin

4. Histomibal

5. Diloxanid Furoate

6. 4-(2,2-dichloro-n-methylacetamido)phenyl Furan-2-carboxylate

7. [4-[(2,2-dichloroacetyl)-methylamino]phenyl] Furan-2-carboxylate

8. Diloxanidefuroate

9. Mls000028653

10. Amebiazol

11. Diloxanide Furoate [usp]

12. Nsc-759146

13. 2-furoic Acid, Ester With 2,2-dichloro-4'-hydroxy-n-methylacetanilide

14. Smr000058857

15. Chebi:4601

16. Yp4n72iw34

17. Diclofurazol

18. Entamide Furoate

19. Ncgc00016637-07

20. Miforon

21. Cas-3736-81-0

22. Diloxanide Furoate (usp)

23. Dsstox_cid_28925

24. Dsstox_rid_83191

25. 2,2-dichloroacetamido-4-n-methylphenyl 2-furoate

26. Dsstox_gsid_48999

27. Entamide 2-furoate

28. 4-(n-methyl-2,2-dichloroacetamido)phenyl 2-furoate

29. Furamide (amebicide)

30. 2,2-dichloro-n-(4-hydroxyphenyl)-n-methylacetamide 2-furoic Acid Ester

31. 2,2-dichloro-n-[4-hydroxyphenyl]-n-methylacetamide 2-furoic Acid Ester

32. Sr-01000003134

33. Einecs 223-108-1

34. 8073 Cb

35. Unii-yp4n72iw34

36. Diloxanidi Furoas

37. Cb 8073

38. Diloxanide Furoate (tn)

39. 2-furancarboxylic Acid, 4-((dichloroacetyl)methylamino)phenyl Ester

40. Opera_id_1633

41. Prestwick0_000903

42. Prestwick1_000903

43. Prestwick2_000903

44. Prestwick3_000903

45. 4-((dichloroacetyl)methylamino)phenyl 2-furoate

46. Schembl23381

47. Bspbio_000746

48. 2,2-dichloroacetamideo-4-n-methylphenyl 2-furoate

49. 4-(2,2-dichlor-n-methylacetamido)phenyl 2-furoat

50. Cid_19529

51. Mls001148648

52. Spbio_002945

53. 4-(n-methyl-2,2-dichloroacetamideo)phenyl 2-furoate

54. Bpbio1_000822

55. Zinc1300

56. Diloxanide Furoate [mi]

57. Chembl1334860

58. Dtxsid8048999

59. Bdbm70295

60. 4-(2,2-dichlor-n-methylacetamido)phenyl 2-furancarboxylat

61. 4-(2,2-dichlor-n-methylacetamido)phenyl 2-furoat [iupac]

62. Hms1570f08

63. Hms2093n21

64. Hms2097f08

65. Hms2234p06

66. Hms3371i07

67. Hms3714f08

68. Pharmakon1600-01505532

69. Diloxanide Furoate [mart.]

70. Diloxanide Furoate [usp-rs]

71. Diloxanide Furoate [who-dd]

72. Diloxanide Furoate [who-ip]

73. Hy-b1147

74. Tox21_113492

75. 4-(2,2-dichlor-n-methylacetamido)phenyl 2-furancarboxylat [iupac]

76. Nsc759146

77. Akos016014036

78. Tox21_113492_1

79. Ccg-213477

80. Cs-4751

81. Db14638

82. Nsc 759146

83. Diloxanidi Furoas [who-ip Latin]

84. Ncgc00016637-01

85. Ncgc00016637-02

86. Ncgc00016637-03

87. Ncgc00016637-04

88. Ncgc00016637-05

89. Ncgc00016637-06

90. Ncgc00016637-10

91. Ncgc00023178-03

92. Ncgc00023178-04

93. Ncgc00023178-05

94. Diloxanide Furoate [usp Monograph]

95. Sbi-0206798.p001

96. Ab00383052

97. Ft-0752403

98. C07637

99. D02480

100. Ab00383052_13

101. Diloxanide Furoate 100 Microg/ml In Acetonitrile

102. Q799564

103. Q-200989

104. Sr-01000003134-2

105. Sr-01000003134-4

106. Brd-k10974103-001-03-9

107. Brd-k10974103-001-14-6

108. [4-[(2,2-dichloroacetyl)-methyl-amino]phenyl] Furan-2-carboxylate

109. [4-[2,2-bis(chloranyl)ethanoyl-methyl-amino]phenyl] Furan-2-carboxylate

110. 2-furancarboxylic Acid, 4-[(2,2-dichloroacetyl)methylamino]phenyl Ester

111. Diloxanide Furoate, United States Pharmacopeia (usp) Reference Standard

112. 2-furancarboxylic Acid [4-[(2,2-dichloro-1-oxoethyl)-methylamino]phenyl] Ester

113. Furan-2-carboxylic Acid [4-[(2,2-dichloroacetyl)-methyl-amino]phenyl] Ester

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 328.1 g/mol
Molecular Formula C14H11Cl2NO4
XLogP33.4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Exact Mass327.0065132 g/mol
Monoisotopic Mass327.0065132 g/mol
Topological Polar Surface Area59.8 Ų
Heavy Atom Count21
Formal Charge0
Complexity383
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Diloxanide is used alone as a primary agent in the treatment of asymptomatic (cyst passers) intestinal amebiasis caused by Entamoeba histolytica. Diloxanide may also be used concurrently, or sequentially, with other agents such as the nitroimidazoles (eg. metronidazole) in the treatment of invasive or extraintestinal forms of amebiasis.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Diloxanide is a luminal amebicide, however the mechanism of action of diloxanide is unknown. Diloxanide destroys the trophozoites of E. histolytica that eventually form into cysts. The cysts are then excreted by persons infected with asymptomatic amebiasis. Diloxanide furoate is a prodrug, and is hydrolyzed in the gastrointestinal tract to produce diloxanide, the active ingredient.


5.2 MeSH Pharmacological Classification

Amebicides

Agents which are destructive to amebae, especially the parasitic species causing AMEBIASIS in man and animal. (See all compounds classified as Amebicides.)


5.3 Absorption, Distribution and Excretion

Absorption

Bioavailability is 90% (in diloxanide parental form), however diloxanide furoate is slowly absorbed from the gastrointestinal tract.


Route of Elimination

Renal (90%, rapidly excreted as glucuronide metabolite). 10% is excreted in the feces as diloxanide.


5.4 Metabolism/Metabolites

Hydrolyzed to furoic acid and diloxanide, which undergoes extensive glucuronidation (99% of diloxanide occurs as glucuronide and 1% as free diloxanide in the systemic circulation).


5.5 Biological Half-Life

3 hours


5.6 Mechanism of Action

Unknown. Diloxanide may inhibit protein synthesis.


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25-Feb-2025
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Looking for 3736-81-0 / Diloxanide Furoate API manufacturers, exporters & distributors?

Diloxanide Furoate manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Diloxanide Furoate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Diloxanide Furoate manufacturer or Diloxanide Furoate supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Diloxanide Furoate manufacturer or Diloxanide Furoate supplier.

PharmaCompass also assists you with knowing the Diloxanide Furoate API Price utilized in the formulation of products. Diloxanide Furoate API Price is not always fixed or binding as the Diloxanide Furoate Price is obtained through a variety of data sources. The Diloxanide Furoate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Diloxanide Furoate

Synonyms

3736-81-0, Dichlofurazol, Furentomin, Histomibal, Diloxanid furoate, 4-(2,2-dichloro-n-methylacetamido)phenyl furan-2-carboxylate

Cas Number

3736-81-0

Unique Ingredient Identifier (UNII)

YP4N72IW34

Diloxanide Furoate Manufacturers

A Diloxanide Furoate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Diloxanide Furoate, including repackagers and relabelers. The FDA regulates Diloxanide Furoate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Diloxanide Furoate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Diloxanide Furoate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Diloxanide Furoate Suppliers

A Diloxanide Furoate supplier is an individual or a company that provides Diloxanide Furoate active pharmaceutical ingredient (API) or Diloxanide Furoate finished formulations upon request. The Diloxanide Furoate suppliers may include Diloxanide Furoate API manufacturers, exporters, distributors and traders.

click here to find a list of Diloxanide Furoate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Diloxanide Furoate USDMF

A Diloxanide Furoate DMF (Drug Master File) is a document detailing the whole manufacturing process of Diloxanide Furoate active pharmaceutical ingredient (API) in detail. Different forms of Diloxanide Furoate DMFs exist exist since differing nations have different regulations, such as Diloxanide Furoate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Diloxanide Furoate DMF submitted to regulatory agencies in the US is known as a USDMF. Diloxanide Furoate USDMF includes data on Diloxanide Furoate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Diloxanide Furoate USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Diloxanide Furoate suppliers with USDMF on PharmaCompass.

Diloxanide Furoate WC

A Diloxanide Furoate written confirmation (Diloxanide Furoate WC) is an official document issued by a regulatory agency to a Diloxanide Furoate manufacturer, verifying that the manufacturing facility of a Diloxanide Furoate active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Diloxanide Furoate APIs or Diloxanide Furoate finished pharmaceutical products to another nation, regulatory agencies frequently require a Diloxanide Furoate WC (written confirmation) as part of the regulatory process.

click here to find a list of Diloxanide Furoate suppliers with Written Confirmation (WC) on PharmaCompass.

Diloxanide Furoate GMP

Diloxanide Furoate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Diloxanide Furoate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Diloxanide Furoate GMP manufacturer or Diloxanide Furoate GMP API supplier for your needs.

Diloxanide Furoate CoA

A Diloxanide Furoate CoA (Certificate of Analysis) is a formal document that attests to Diloxanide Furoate's compliance with Diloxanide Furoate specifications and serves as a tool for batch-level quality control.

Diloxanide Furoate CoA mostly includes findings from lab analyses of a specific batch. For each Diloxanide Furoate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Diloxanide Furoate may be tested according to a variety of international standards, such as European Pharmacopoeia (Diloxanide Furoate EP), Diloxanide Furoate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Diloxanide Furoate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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