Find Ethylene Dichloride manufacturers, exporters & distributors on PharmaCompass

PharmaCompass

Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

0

CEP/COS

CEP/COS Certifications

0

JDMF

JDMFs Filed

0

EU WC

EU WC

0

KDMF

KDMF

0

NDC API

NDC API

0

VMF

NDC API

0

Listed Suppliers

Other Suppliers

0INTERMEDIATES

REF. STANDARDS OR IMPURITIES

0

EDQM

0

USP

0

JP

0

Others

FINISHED DOSAGE FORMULATIONS

0

FDF Dossiers

FDF Dossiers

0

FDA Orange Book

FDA (Orange Book)

0

Europe

Europe

0

Canada

Canada

0

Australia

Australia

0

South Africa

South Africa

0

Listed Dossiers

Listed Dossiers

0 DRUGS IN DEVELOPMENT

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

API REF. PRICE (USD/KG)

GLOBAL SALES INFORMATION

US Medicaid

NA

Annual Reports

NA

Regulatory FDF Prices

NA

API/FDF Prices: Book a Demo to
explore the features and consider
upgrading later

MARKET PLACE

0

API

0

FDF

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

Chemistry

Click the arrow to open the dropdown
read-moreClick the button for full data set
Also known as: Ethylene dichloride, 107-06-2, Ethylene chloride, Ethane, 1,2-dichloro-, Glycol dichloride, Dichloroethylene
Molecular Formula
C2H4Cl2
Molecular Weight
98.96  g/mol
InChI Key
WSLDOOZREJYCGB-UHFFFAOYSA-N
FDA UNII
55163IJI47

Ethylene Dichloride
Ethylene Dichloride is a clear, colorless, oily, synthetic, flammable liquid chlorinated hydrocarbon with a pleasant chloroform-like smell that emits toxic fumes of hydrochloric acid when heated to decomposition. Ethylene dichloride is primarily used to produce vinyl chloride. Inhalation exposure to this substance induces respiratory distress, nausea and vomiting and affects the central nervous system, liver and kidneys. It is mutagenic in animals and is reasonably anticipated to be a human carcinogen. (NCI05)
1 2D Structure

Ethylene Dichloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1,2-dichloroethane
2.1.2 InChI
InChI=1S/C2H4Cl2/c3-1-2-4/h1-2H2
2.1.3 InChI Key
WSLDOOZREJYCGB-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C(CCl)Cl
2.2 Other Identifiers
2.2.1 UNII
55163IJI47
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Ethylene Dichloride

2. Ethylene Dichloride, 14c-labeled

3. Ethylene Dichloride, 14c2-labeled

4. Ethylene Dichloride, 36cl-labeled

5. Ethylene Dichloride, 38cl-labeled

6. Ethylene Dichloride, Ion (1+)

2.3.2 Depositor-Supplied Synonyms

1. Ethylene Dichloride

2. 107-06-2

3. Ethylene Chloride

4. Ethane, 1,2-dichloro-

5. Glycol Dichloride

6. Dichloroethylene

7. Dutch Liquid

8. Dutch Oil

9. Ethane Dichloride

10. Aethylenchlorid

11. Dichloro-1,2-ethane

12. Sym-dichloroethane

13. Dichloremulsion

14. 1,2-dichlorethane

15. Brocide

16. 1,2-bichloroethane

17. Dichlor-mulsion

18. Bichlorure D'ethylene

19. Borer Sol

20. Di-chlor-mulsion

21. 1,2-dce

22. Freon 150

23. Alpha,beta-dichloroethane

24. Edc (halocarbon)

25. 1,2-ethylene Dichloride

26. Destruxol Borer-sol

27. Ethyleendichloride

28. Cloruro Di Ethene

29. Rcra Waste Number U077

30. 1,2-dicloroetano

31. 1,2-ethylidene Dichloride

32. Chlorure D'ethylene

33. 1,2-dichloorethaan

34. Dce

35. 1,2-dichlor-aethan

36. 1, 2-dichloroethane

37. Aethylendichlorid

38. S-dichloroethane

39. Hcc 150

40. Ethylenedichloride

41. Nci-c00511

42. Edc

43. Ent 1,656

44. 1,2-dichloraethan

45. 1.2-dichloroethane

46. .alpha.,.beta.-dichloroethane

47. 1,2-dichloro-ethane

48. Mfcd00000963

49. Chebi:27789

50. Ethane, 1,2-dichloro-, Homopolymer

51. 55163iji47

52. Caswell No. 440

53. Aethylenchlorid [german]

54. Ry Dichloro-1,2-ethane

55. Ethyleendichloride [dutch]

56. 1,2-dichloroethane, Analytical Standard

57. Cloruro Di Ethene [italian]

58. 29561-65-7

59. 52399-93-6

60. Hsdb 65

61. 1,2-dichloorethaan [dutch]

62. 1,2-dicloroetano [italian]

63. Ccris 225

64. Chlorure D'ethylene [french]

65. 1,2 Dichloroethane

66. 1,2-dichlor-aethan [german]

67. Bichlorure D'ethylene [french]

68. Dichlorure D'ethylene

69. Dichloro-1,2-ethane [french]

70. Clch2ch2cl

71. Ethylene Dichloride [bsi:iso]

72. 1,2-dichloroethane 100 Microg/ml In Methanol

73. Dichlorure D'ethylene [iso-french]

74. Einecs 203-458-1

75. Un1184

76. Rcra Waste No. U077

77. Epa Pesticide Chemical Code 042003

78. Ethylenechloride

79. Ethylendichloride

80. Ai3-01656

81. Alpha,bet

82. Dichloro Ethylene

83. Ethylene-chloride

84. Unii-55163iji47

85. Ethylene Dichoride

86. 1,2-dichloroethane, Acs

87. 1,2dichlorethane

88. 1,2dichloroethane

89. Ehtylene Dichloride

90. 1,2 Dichlorethane

91. 1,2 Dichoroethane

92. 1,2-dichloroetane

93. 1,2-dichloroethan

94. 1,2-dichoroethane

95. 1,2-dicloroethane

96. 1,2-dichioroethane

97. 1,2-dichloroetharie

98. 1 ,2-dichloroethane

99. 1, 2 Dichloroethane

100. 1,2 -dichloroethane

101. 1,2 Dichloro Ethane

102. 1,2,-dichloroethane

103. 1,2- Dichloroethane

104. 1,2-di-chloroethane

105. 1,2-dichloro Ethane

106. 1.2-di-chloroethane

107. Ch2clch2cl

108. 1,2-ethylenedichloride

109. Clch2-ch2cl

110. Dichloro-1, 2-ethane

111. C1ch2ch2cl

112. Clch2ch2c1

113. Edc, Jmaf

114. Cl(ch2)2cl

115. Dsstox_cid_438

116. 12-dichloroethane

117. Bmse000568

118. Ec 203-458-1

119. Dsstox_rid_75587

120. Dsstox_gsid_20438

121. Chembl16370

122. 1,2-dichloroethane Acs Grade

123. 1,2-dichloroethane, For Hplc

124. Ethylene Dichloride, Bsi, Iso

125. Dtxsid6020438

126. Ethylene Dichloride [mi]

127. Dichloroethane Reagent Grade Acs

128. Ethylene Dichloride [fcc]

129. Ethylene Dichloride [iso]

130. 1,2-dichloroethane, Acs Reagent

131. 1,2-dichloroethane, Hplc Grade

132. Ethylene Dichloride [hsdb]

133. Ethylene Dichloride [inci]

134. 1,2-dichloroethane [iarc]

135. Amy33455

136. Ethylene Dichloride [mart.]

137. Zinc8220695

138. Tox21_202466

139. 1,2-dichloroethane, Lr, >=99%

140. Ethylene Dichloride [who-dd]

141. Stl264187

142. 1,2-dichloroethane [usp-rs]

143. Akos000120021

144. 1,2-dichloroethane, P.a., 99.5%

145. Db03733

146. Un 1184

147. 1,2-dichloroethane, Ar, >=99.5%

148. 1,2-dichloroethane, Anhydrous, 99.8%

149. Ncgc00091763-01

150. Ncgc00091763-02

151. Ncgc00091763-03

152. Ncgc00260015-01

153. Cas-107-06-2

154. 1,2-dichloroethane, For Hplc, 99.8%

155. 1,2-dichloroethane, Acs Reagent, >=99%

156. 1,2-dichloroethane, Reagentplus(r), 99%

157. 1,2-dichloroethane, For Hplc, >=99.8%

158. 1,2-dichloroethane, Spectrophotometric Grade

159. D0310

160. D0364

161. E0289

162. Ft-0626325

163. Ft-0771283

164. R 150

165. 1,2-dichloroethane 10 Microg/ml In Methanol

166. 1,2-dichloroethane, Acs Reagent, >=99.0%

167. C06752

168. 1,2-dichloroethane 1000 Microg/ml In Methanol

169. 1,2-dichloroethane, Saj First Grade, >=99.0%

170. Q161480

171. 1,2-dichloroethane, Jis Special Grade, >=99.5%

172. Ethylene Dichloride [un1184] [flammable Liquid]

173. J-503815

174. 1,2-dichloroethane, Anhydrous, Zero2(tm), 99.8%

175. 1,2-dichloroethane, Spectrophotometric Grade, >=99%

176. Ethambutol Hydrochloride Impurity D [ep Impurity]

177. 1,2-dichloroethane, Puriss., Absolute, Over Molecular Sieve (h2o <=0.005%), >=99.5% (gc)

2.4 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 98.96 g/mol
Molecular Formula C2H4Cl2
XLogP31.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count0
Rotatable Bond Count1
Exact Mass97.9690055 g/mol
Monoisotopic Mass97.9690055 g/mol
Topological Polar Surface Area0 Ų
Heavy Atom Count4
Formal Charge0
Complexity6
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Minimum/Potential Fatal Human Dose

A case /was reported/ of an 18-yr old man who becamee drowsy, cyanotic, and exhibited bradycardia after drinking approx 50 mL of Marament which is equivalent to 50 g of 1,2-dichloroethane (714 mg/kg/day); he died 17 hr later in a state of circulatory shock.

DHHS/ATSDR; Toxicological Profile for 1,2-Dichloroethane p. 33 TP-93/06 (1994)


Ingestion of 1 or 2 oz, 400-800 mg/kg body weight, by an adult male is fatal, deaths caused by circulatory or respiratory failure.

USEPA; Intermedia Priority Pollutant Guidance Doc p.2-1 (1982)


5 Pharmacology and Biochemistry
5.1 Absorption, Distribution and Excretion

The compound 1,2-dichloroethane (DCE) is a ubiquitous environmental contaminant. The primary route of exposure of humans to DCE is inhalation of its vapor. The present investigation was undertaken to determine the distribution and accumulation of DCE in the blood, lung, liver, brain, kidney and abdominal fat of rats during and after inhalation exposure. Male rats were exposed to 160 ppm (v/v) of DCE vapor for 360 min and the concentrations of DCE in the blood and tissues during the inhalation exposure period and after the end of the exposure period were measured. DCE accumulation in the abdominal fat was much greater than that in the blood and other tissues. The information we obtained in this study is useful basic data pertaining to the pharmacokinetics of DCE and DCE-mediated carcinogenicity: Our results suggest that one of the factors involved in the induction of peritoneal tumors in rats exposed to DCE vapor by inhalation is DCE accumulation in the abdominal fat.

PMID:23573923 Take M et al; J Environ Sci Health A Tox Hazard Subst Environ Eng 48 (9): 1031-6 (2013)


The effect of the pretreatment of male Sprague-Dawley rats with phenobarbital (PB), butylated hydroxyanisole (BHA) and disulfiram (DSF) on the inhalation kinetics of 1,2-dichloroethane [ethylene dichloride (EDC)] was studied by the gas uptake method. A closed recirculating system was constructed and characterized. The rate curves in all the pretreatment regimens showed saturable dependence on EDC concentration. These saturable dependencies (Michaelis-Menten) appeared to be associated with enzymatic metabolism. In general, a two-compartment, steady-state pharmacokinetic model described the uptake data. Data were transformed by Hanes plots to calculate the inhalational Km, the ambient EDC concentration at which uptake proceeded at half maximum rate, and Vmax, the maximum rate of uptake (i.e., maximum rate of metabolism). Although PB and BHA pretreatments did not affect the Km of EDC, PB pretreatment increased the Vmax while DSF pretreatment decreased both the Km and Vmax.

PMID:3813877 Igwe OJ et al; Arch Toxicol 59 (3): 127-34 (1986)


The levels of 1,2-dichloroethane (1,2-EDC), and its metabolites 2-chloroethanol, monochloroacetic acid, and 2-chloroacetaldehyde were determined by gas chromatography in the organs of human cadavers in cases of acute poisoning. The highest 1,2-dichloroethane levels were observed in the stomach and omentum; lower levels in the kidney, spleen, brain, heart, large and small intestines, and blood, and no detectable amounts in the liver. 2-Chloroethanol and monochloroacetic acid, minor metabolites of 1,2-dichloroethane, were detected in small amounts in the myocardium, brain, stomach, and small intestine. 2-Chloroacetaldehyde, because it is a reactive intermediate in the biotransformation of 1,2-dichloroethane was not detectable in the organs. The administration of acetylcysteine to acutely intoxicated humans showed no positive clinical effect. ...

Luzhnikov EA et al; Sud Med Ekspert 28 (2): 47-9 (1985)


Urinary excretion of thiodiglycolic acid and thioethers after 1,2-dichloroethane dosing was studied in rats. Male Sprague-Dawley rats were administered 0, 0.12, 0.25, 0.50, 1.01, 2.02, 4.04 or 8.08 umol/kg (14)C labeled 1,2-dichloroethane orally. Urine samples were collected for 24 hours and analyzed for thiodiglycolic acid and thioethers before and after alkaline hydrolysis by gas chromatography and the Ellman reagent/absorption spectrophotometry (thioether assay), respectively. The amounts of 1,2-dichloroethane derived radioactivity excreted decreased as a logarithmic function of increasing 1,2-dichloroethane dose ranging from 62.1% of the dose for 0.12 and 0.25 umol/kg 1,2-dichloroethane to 7.4% of the 8.08 umol/kg dose. The concentrations of urinary thiodiglycolic acid were well correlated with 1,2-dichloroethane dose up to 2.02 umol/kg. When expressed as a percentage of the dose urinary excretion of thiodiglycolic acid was not dependent on the dose over the range 0.12 to 1.01 umol/kg 1,2-dichloroethane and amounted to 21.8% of the dose. Before alkaline hydrolysis no thioethers could be detected. After alkaline hydrolysis, urinary excretion of thioethers by rats dosed with 0.12 and 0.25 umol/kg did not differ significantly from the control value. Between 0.25 and 4.04 umol/kg 1,2-dichloroethane, thioether excretion increased linearly with dose. The highest thioether/thiodiglycolic ratio 0.17 occurred in rats given 8.08 umol/kg 1,2-dichloroethane. Urinary thiodiglycolic acid concentrations were not altered by alkaline hydrolysis. The /results suggest/ that urinary thiodiglycolic acid excretion correlates well with the oral dose of 1,2-dichloroethane in rats. Urinary thiodiglycolic acid excretion may be a useful marker of 1,2-dichloroethane exposure. Thiodiglycolic acid is hydrolyzed under alkaline conditions. The thioether assay is not appropriate for estimating urinary thiodiglycolic acid excretion.

Payan JP et al J Appl Toxicol 13 (6): 417-22 (1993)


For more Absorption, Distribution and Excretion (Complete) data for 1,2-Dichloroethane (11 total), please visit the HSDB record page.


5.2 Metabolism/Metabolites

In rats, radiolabeled ethylene dichloride was excreted primarily in the urine, and the major urinary metabolites were chloroacetic acid, 5-carboxymethyl cysteine, and thiodiacetic acid.

Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-164


The metabolism and binding of (14)C-labelled 1,2-dichloroethane in female C57BL mice were studied. As shown by whole-body autoradiography of iv injected mice, a selective localization of non-volatile and bound 1,2-dichloroethane metabolites occurred in the nasal olfactory mucosa and the tracheo-bronchial epithelium. Low levels of metabolites were also present in the epithelia of the upper alimentary tract, vagina and eyelid, and in the liver and kidney. A decreased mucosal and epithelial binding was observed after pretreatment with metyrapone, indicating that the binding might be due to an oxidative metab of 1,2-dichloroethane. The levels of in vivo binding were considerably lower in mice injected ip with 1,2-dichloroethane as compared to mice given equimolar doses of (14)C-labelled 1,2-dibromoethane. In vitro experiments with 1000 g supernatants from various tissues showed that nasal mucosa has a marked ability to activate 1,2-dichloroethane into products that become irreversibly bound to the tissue. The nasal olfactory mucosa is a target tissue for toxicity of 1,2-dichloroethane.

Brittebo EB et al; Toxicol 56 (1): 35-45 (1989)


... Using isolated rat hepatocytes as a model system, and electron spin resonance spectroscopy coupled to the spin trapping technique as a detection technique, the formation of free radical derivatives was demonstrated, both under normoxic as well as under hypoxic conditions from carbon tetrachloride (CCl4), chloroform (CHCl3), 1,1,1-tetrachloroethane, and 1,1,2,2-tetrachloroethane. In contrast, free radical production was only detectable under hypoxic conditions when 1,2-dibromoethane, 1,1-dichloroethane, 1,2-dichloroethane, and 1,1,2-trichloroethane were added to the hepatocyte suspensions....

PMID:6393297 Tomasi A et al; Toxicol Pathol 12 (3): 240-6 (1984)


Chlorinated hydrocarbons found in a bioassay to be carcinogenic to both B6C3F1 mice and Osborne-Mendel rats (1,2-dichloroethane), carcinogenic only to mice (1,1,2-trichloroethane, 1,1,2,2-tetrachloroethane, hexachloroethane, trichloroethylene, and tetrachloroethylene), and noncarcinogenic to either species (1,1-dichloroethane and 1,1,1-trichloroethane) were used to investigate the biochemical bases for tumorigenesis. Studies were conducted after chronic oral dosing of adult mice and rats with the MTD and 1/4 MTD of each compound. The extent to which the compounds were metabolized in 48 hr, hepatic protein binding, and urinary metabolite patterns were examined. Metabolism of the compounds (mmoles per kg body weight) was 1.7 to 10 times greater in mice than in rats. Hepatic protein binding (nanomole equivalents bound to 1 mg of liver protein) was 1.2 to 8.3 times higher in mice than in rats except for 1,2-dichloroethane and 1,1,1-trichloroethane. The noncarcinogens 1,1-dichloroethane and 1,1,1-trichloroethane exhibited 2 to 18 times more binding in mice than did the carcinogens 1,2-dichloroethane and 1,1,2-trichloroethane. Urinary metabolite patterns of the compounds were similar in both species. The biochemical parameters measured provided no clue to differentiate the carcinogens from the noncarcinogens.

PMID:4054011 Mitoma C et al; Drug Chem Toxicol 8 (3): 183-94 (1985)


For more Metabolism/Metabolites (Complete) data for 1,2-Dichloroethane (16 total), please visit the HSDB record page.


5.3 Biological Half-Life

Whole body (animal studies): complete elimination within 48 hours; [TDR, p. 649]

TDR - Ryan RP, Terry CE, Leffingwell SS (eds). Toxicology Desk Reference: The Toxic Exposure and Medical Monitoring Index, 5th Ed. Washington DC: Taylor & Francis, 1999., p. 649


5.4 Mechanism of Action

The mechanism of the hepatocellular toxicity of l,2-dichloroethane ... was examined in vitro. Hepatocytes from male Wistar rats were preloaded with tritium (3)H labeled sodium palmitate and (14)C labeled glucosamine. They were incubated with 0 to 6.5 uM 1,2-dichloroethane for 5 to 60 min. Cytotoxicity was assessed by measuring changes in cellular exclusion of trypan blue dye leakage of intracellular lactate dehydrogenase (LDH) into the medium and depletion of intracellular reduced glutathione (GSH). The cells were separated into the cytosolic microsome total Golgi apparatus and secreted lipoglycoprotein fractions which were assayed for changes in the distribution of (3)H and (14)C activity. 1,2-Dichloroethane did not significantly affect cellular trypan blue exclusion and LDH leakage until after 30 and 15 min incubation respectively. Hepatocellular GSH concentrations were significantly decreased after 5 min. Incubation with 4.4 uM 1,2-dichloroethane. 1,2-Dichloroethane large decrease in lipoglycoprotein secretion which was accompanied by significant accumulations of (3)H and (14)C activity in the cells. The levels of (3)H and (14)C activity were significantly increased in the microsomes and Golgi apparatus after 5 and 15 min of 1,2-dichloroethane treatment. Within the lipoglycoprotein fraction 1,2-dichloroethane significantly decreased the amounts of radiolabel in the lipid and sugar moieties. ...

Cottalasso D et al; Occupat Environ Med 51 (4): 281-85 (1994)


DNA sequence changes produced by 1,2-dibromoethane, 1,2-dichloroethane and 1-bromo-2-chloroethane were analyzed using the vermilion locus of Drosophila melanogaster. Under excision repair proficient (exr+) conditions (mutagenized exr+ males mated with exr+ females) all mutants isolated from the first generation (Fl) after 1,2-dibromoethane and 1,2-dichloroethane exposure represented rearrangements (multi-locus deletions, small deletions with tandem repeats, duplicate insertions). By contrast mutants expressing a vermilion phenotype only in the F2 (Fl mosaics) all carried single bp changes. When exr+ males after exposure to 1,2-dibromoethane were mated to excision repair deficient (exr-) mus 201 females 11 of 14 mutational events isolated from either Fl or F2 progeny were single bp changes. In general the mutation spectra for the three dihaloalkanes were similar to the spectrum obtained at the same locus for the direct acting monofunctional agent methylmethanesulfonate. The data lend support to the conclusions that these 1,2-dihaloalkanes are genotoxic through modification at ring nitrogens in DNA primarily at the N7 of guanine and, lesser extent, at the N1 of adenine. These N-adducts could be directly miscoding. However, more important for the mutagenic action of chemicals seems to be the formation of non-coding lesions and/or misrepair.

PMID:8200089 Ballering LA et al; Carcinogenesis 15 (5): 869-75 (1994)


The mechanism of action for 1,2-dichloroethane-induced toxicity is not known. However, studies in rats and mice indicate that 1,2-dichloroethane may be metabolized to 2-chloroacetaldehyde, S-(2-chloroethyl)glutathione, and other putative reactive intermediates capable of binding covalently to cellular macromolecules ... . The ability of a chemical to bind covalently to cellular macromolecules is often correlated with the induction of toxic effects ... . In addition, 1,2-dichloroethane has been shown to promote lipid peroxidation in vitro ... . Lipid peroxidation is also assoc with production of tissue damage. The lag time between inhalation exposure and onset of effects ... in an occupationally exposed 51-yr old male may have been a reflection, in part, of the time required to metabolize 1,2-dichloroethane to active intermediates.

DHHS/ATSDR; Toxicological Profile for 1,2-Dichloroethane p. 71 TP-93/06 (1994)


Digital Content read-more

Create Content with PharmaCompass, ask us

NEWS #PharmaBuzz

read-more
read-more

Market Place

Do you need sourcing support? Ask us

ABOUT THIS PAGE

Looking for 107-06-2 / Ethylene Dichloride API manufacturers, exporters & distributors?

Ethylene Dichloride manufacturers, exporters & distributors 1

13

PharmaCompass offers a list of Ethylene Dichloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Ethylene Dichloride manufacturer or Ethylene Dichloride supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Ethylene Dichloride manufacturer or Ethylene Dichloride supplier.

PharmaCompass also assists you with knowing the Ethylene Dichloride API Price utilized in the formulation of products. Ethylene Dichloride API Price is not always fixed or binding as the Ethylene Dichloride Price is obtained through a variety of data sources. The Ethylene Dichloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Ethylene Dichloride

Synonyms

107-06-2, Ethylene chloride, Ethane, 1,2-dichloro-, Glycol dichloride, Dichloroethylene, Dutch liquid

Cas Number

107-06-2

Unique Ingredient Identifier (UNII)

55163IJI47

About Ethylene Dichloride

Ethylene Dichloride is a clear, colorless, oily, synthetic, flammable liquid chlorinated hydrocarbon with a pleasant chloroform-like smell that emits toxic fumes of hydrochloric acid when heated to decomposition. Ethylene dichloride is primarily used to produce vinyl chloride. Inhalation exposure to this substance induces respiratory distress, nausea and vomiting and affects the central nervous system, liver and kidneys. It is mutagenic in animals and is reasonably anticipated to be a human carcinogen. (NCI05)

Ethylene Dichloride Manufacturers

A Ethylene Dichloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ethylene Dichloride, including repackagers and relabelers. The FDA regulates Ethylene Dichloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ethylene Dichloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Ethylene Dichloride Suppliers

A Ethylene Dichloride supplier is an individual or a company that provides Ethylene Dichloride active pharmaceutical ingredient (API) or Ethylene Dichloride finished formulations upon request. The Ethylene Dichloride suppliers may include Ethylene Dichloride API manufacturers, exporters, distributors and traders.

click here to find a list of Ethylene Dichloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Ethylene Dichloride USDMF

A Ethylene Dichloride DMF (Drug Master File) is a document detailing the whole manufacturing process of Ethylene Dichloride active pharmaceutical ingredient (API) in detail. Different forms of Ethylene Dichloride DMFs exist exist since differing nations have different regulations, such as Ethylene Dichloride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Ethylene Dichloride DMF submitted to regulatory agencies in the US is known as a USDMF. Ethylene Dichloride USDMF includes data on Ethylene Dichloride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Ethylene Dichloride USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Ethylene Dichloride suppliers with USDMF on PharmaCompass.

Ethylene Dichloride GMP

Ethylene Dichloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Ethylene Dichloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ethylene Dichloride GMP manufacturer or Ethylene Dichloride GMP API supplier for your needs.

Ethylene Dichloride CoA

A Ethylene Dichloride CoA (Certificate of Analysis) is a formal document that attests to Ethylene Dichloride's compliance with Ethylene Dichloride specifications and serves as a tool for batch-level quality control.

Ethylene Dichloride CoA mostly includes findings from lab analyses of a specific batch. For each Ethylene Dichloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Ethylene Dichloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Ethylene Dichloride EP), Ethylene Dichloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ethylene Dichloride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty