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Chemistry

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Also known as: Heme, Heme b, 14875-96-8, Ferroprotoporphyrin, Ferroheme, Reduced hematin
Molecular Formula
C34H32FeN4O4
Molecular Weight
616.5  g/mol
InChI Key
KABFMIBPWCXCRK-UHFFFAOYSA-L
FDA UNII
42VZT0U6YR

Heme
The color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.
1 2D Structure

Heme

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;iron(2+)
2.1.2 InChI
InChI=1S/C34H34N4O4.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);/q;+2/p-2
2.1.3 InChI Key
KABFMIBPWCXCRK-UHFFFAOYSA-L
2.1.4 Canonical SMILES
CC1=C(C2=CC3=C(C(=C([N-]3)C=C4C(=C(C(=N4)C=C5C(=C(C(=N5)C=C1[N-]2)C)C=C)C)C=C)C)CCC(=O)O)CCC(=O)O.[Fe+2]
2.2 Other Identifiers
2.2.1 UNII
42VZT0U6YR
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Ferroprotoporphyrin

2. Haem

3. Heme

4. Heme B

5. Protoheme Ix

2.3.2 Depositor-Supplied Synonyms

1. Heme

2. Heme B

3. 14875-96-8

4. Ferroprotoporphyrin

5. Ferroheme

6. Reduced Hematin

7. Haem

8. Protoheme Ix

9. Iron Protoporphyrin Ix

10. Hematin

11. Protohaem

12. Ferrous Protoheme

13. Iron Protoporphyrin

14. Ferrous Protoheme Ix

15. Ferroprotoporphyrin Ix

16. 42vzt0u6yr

17. Iron(ii) Protoporphyrin Ix

18. Normosang

19. 3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic Acid;iron(2+)

20. Protoheme Ix (van)

21. Ferroheme (van)

22. Heme (van)

23. Hem

24. Unii-42vzt0u6yr

25. Nsc 16669

26. Globifer

27. Nsc 267100

28. Human Hemin

29. Heme Iron

30. Heme [mi]

31. Gtpl4349

32. Mfcd00870215

33. Ferrate(2-), (7,12-diethenyl-3,8,13,17-tetramethyl-21h,23h-porphine-2,18-dipropanoato(4-)-n21,n22,n23,n24)-, Dihydrogen, (sp-4-2)-

34. 85758-ep2270016a1

35. 85758-ep2270505a1

36. 85758-ep2305243a1

37. 85758-ep2305825a1

38. Q620084

39. Iron, (dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-))-

40. [7,12-diethenyl-3,8,13,17-tetramethyl-21h,23h-porphine-2,18-dipropanoato(4-)-n^21,n^22,n^23,n^24]-ferrate(2-)dihydrogen

41. 3-[18-(2-carboxyethyl)-3,8,13,17-tetramethyl-7,12-divinyl-porphyrin-21,23-diid-2-yl]propanoic Acid

42. Ferrate(2-), (7,12-diethenyl-3,8,13,17-tetramethyl-21h,23h-porphine-2,18-dipropanoato(4-)-kappan21,kappan22,kappan23,kappan24)-, Dihydrogen, (sp-4-2)-

43. Ferrate(2-), (7,12-diethenyl-3,8,13,17-tetramethyl-21h,23h-porphine-2,18-dipropanoato(4-)-kappan21,kappan22,kappan23,kappan24)-, Hydrogen (1:2), (sp-4-2)-

44. Ferrous 3-[(1z,4z,9z,15z)-18-(2-carboxyethyl)-3,7,12,17-tetramethyl-8,13-divinyl-21,23-dihydroporphyrin-2-yl]propanoic Acid

2.4 Create Date
2005-08-01
3 Chemical and Physical Properties
Molecular Weight 616.5 g/mol
Molecular Formula C34H32FeN4O4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count8
Exact Mass616.177291 g/mol
Monoisotopic Mass616.177291 g/mol
Topological Polar Surface Area102 Ų
Heavy Atom Count43
Formal Charge0
Complexity1010
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2

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01-Jan-2021
28-Feb-2025
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ABOUT THIS PAGE

Looking for 14875-96-8 / Heme API manufacturers, exporters & distributors?

Heme manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Heme API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Heme manufacturer or Heme supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Heme manufacturer or Heme supplier.

PharmaCompass also assists you with knowing the Heme API Price utilized in the formulation of products. Heme API Price is not always fixed or binding as the Heme Price is obtained through a variety of data sources. The Heme Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Heme

Synonyms

Heme b, 14875-96-8, Ferroprotoporphyrin, Ferroheme, Reduced hematin, Haem

Cas Number

14875-96-8

Unique Ingredient Identifier (UNII)

42VZT0U6YR

About Heme

The color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.

Heme Manufacturers

A Heme manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Heme, including repackagers and relabelers. The FDA regulates Heme manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Heme API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Heme manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Heme Suppliers

A Heme supplier is an individual or a company that provides Heme active pharmaceutical ingredient (API) or Heme finished formulations upon request. The Heme suppliers may include Heme API manufacturers, exporters, distributors and traders.

click here to find a list of Heme suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Heme GMP

Heme Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Heme GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Heme GMP manufacturer or Heme GMP API supplier for your needs.

Heme CoA

A Heme CoA (Certificate of Analysis) is a formal document that attests to Heme's compliance with Heme specifications and serves as a tool for batch-level quality control.

Heme CoA mostly includes findings from lab analyses of a specific batch. For each Heme CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Heme may be tested according to a variety of international standards, such as European Pharmacopoeia (Heme EP), Heme JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Heme USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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