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Also known as: Sacubitril sodium, 149690-05-1, Ahu-377 sodium, Sacubitril (sodium), Mop72gep8z, Sodium;4-[[(2s,4r)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoate
Molecular Formula
C24H28NNaO5
Molecular Weight
433.5  g/mol
InChI Key
RRTBVEJIZWGATF-JKSHRDEXSA-M
FDA UNII
MOP72GEP8Z

Sacubitril Sodium
1 2D Structure

Sacubitril Sodium

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
sodium;4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoate
2.1.2 InChI
InChI=1S/C24H29NO5.Na/c1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19;/h4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28);/q;+1/p-1/t17-,21+;/m1./s1
2.1.3 InChI Key
RRTBVEJIZWGATF-JKSHRDEXSA-M
2.1.4 Canonical SMILES
CCOC(=O)C(C)CC(CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)[O-].[Na+]
2.1.5 Isomeric SMILES
CCOC(=O)[C@H](C)C[C@@H](CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)[O-].[Na+]
2.2 Other Identifiers
2.2.1 UNII
MOP72GEP8Z
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Sacubitril Sodium

2. 149690-05-1

3. Ahu-377 Sodium

4. Sacubitril (sodium)

5. Mop72gep8z

6. Sodium;4-[[(2s,4r)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoate

7. Unii-mop72gep8z

8. Sacubitril Sodium Salt

9. Sacubitril Sodium [mi]

10. Schembl21239956

11. Dtxsid90164362

12. Hy-15407b

13. (1,1'-biphenyl)-4-pentanoic Acid, Gamma-((3-carboxy-1-oxopropyl)amino)-alpha-methyl-, 4-ethyl Ester, Sodium Salt (1:1), (alphar,gammas)-

14. Cs-0079358

15. A937423

16. Q27284149

17. (1,1'-biphenyl)-4-pentanoic Acid, .gamma.-((3-carboxy-1-oxopropyl)amino)-.alpha.-methyl-, 4-ethyl Ester, Sodium Salt (1:1), (.alpha.r,.gamma.s)-

18. Sodium 4-(((2s,4r)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate

2.4 Create Date
2008-02-05
3 Chemical and Physical Properties
Molecular Weight 433.5 g/mol
Molecular Formula C24H28NNaO5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count12
Exact Mass433.18651728 g/mol
Monoisotopic Mass433.18651728 g/mol
Topological Polar Surface Area95.5 Ų
Heavy Atom Count31
Formal Charge0
Complexity556
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2

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Submission : 2024-08-28

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Raks Pharma Pvt Ltd

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DMF Review : Complete

Rev. Date : 2019-05-28

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DMF Number : 33476

Submission : 2018-12-31

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Laurus Labs

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Sacubitril Sodium IH

Date of Issue : 2023-07-03

Valid Till : 2025-07-02

Written Confirmation Number : WC-0213

Address of the Firm : Plot No.21, Jawaharlal Nehru Pharma City, Parawada MandaI, Visakhapatnam, Visakh...

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Sacubitril Sodium IH

Date of Issue : 2019-10-15

Valid Till : 2022-08-08

Written Confirmation Number : WC-0383A4

Address of the Firm : Sy. No.455/A, 455/AA, 455/E & 455/EE Chandampet Village Shankarampet Mandal Meda...

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SACUBITRIL

NDC Package Code : 52076-6260

Start Marketing Date : 2016-05-25

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

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NDC Package Code : 65727-079

Start Marketing Date : 2019-04-15

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

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NDC Package Code : 69766-057

Start Marketing Date : 2018-10-29

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

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NDC Package Code : 72023-0012

Start Marketing Date : 2024-10-01

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

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LGM Pharma

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About the Company : LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, ...

LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, analytical method development and testing, and commercial manufacturing. LGM Pharma offers custom API synthesis, analytical development, and regulatory services. With a network of over 300 accredited CGMP manufacturing partners, LGM provides unparalleled supply chain security. And, with over 100,000 square feet of FDA-inspected cGMP manufacturing and warehouse capacity, LGM Pharma provides a one-stop solution for solid dose, powder, semi-solid and liquid drugs.
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About the Company : Established in 2004, Metrochem API is one of the fastest-growing APIs, pellets & intermediates manufacturers. It has 6 dedicated manufacturing facilities for its 3 core product gro...

Established in 2004, Metrochem API is one of the fastest-growing APIs, pellets & intermediates manufacturers. It has 6 dedicated manufacturing facilities for its 3 core product groups and has been approved by ISO 9001-2015, USFDA, WHO GMP, Cofepris & Japanese authorities. Metrochem’s in-depth industry knowledge, & hi-tech & advanced infrastructure, helps it provide quality products to its customers. Note: None of the products will be supplied to the countries where this could conflict with existing patents. Further, any products under patent will be offered for R&D purposes only. However, the final responsibility lies with the buyer
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About the Company : Ami Lifesciences, established in 2006, is one of the fastest growing API manufacturing companies in India. Specializing in cardiovascular, anti-diabetic, CNS, and respiratory thera...

Ami Lifesciences, established in 2006, is one of the fastest growing API manufacturing companies in India. Specializing in cardiovascular, anti-diabetic, CNS, and respiratory therapeutic areas, Ami offers a wide range of APIs, intermediates, key starting materials, as well as contract bulk manufacturing services. Ami's manufacturing units in Gujarat and Karnataka feature dedicated clean rooms for APIs and adhere to international standards like EU-GMP, WHO-GMP, PMDA, and COFEPRIS. Ami serves as a reliable partner for contract development and manufacturing, offering generic APIs to global pharma companies across more than 60 countries.
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Sacubitril Sodium

About the Company : HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It...

HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It offers services such as sourcing, manufacturing & supply, helping partners enter new markets worldwide. Its strong partnerships with major players in the pharma and food additive industries help HRV Global effectively promote projects and products. HRV Global represents over 30 large Indian drugmakers, primarily targeting Europe, the US & the Middle East markets. Headquartered in India, HRV Global has offices in the US, Switzerland, Dubai, Lithuania & Turkey.
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About the Company : Mankind Pharma, came into existence in 1986. In 1991, the company was formed into a legal corporation. However, it actively started working as a fully integrated pharmaceutical com...

Mankind Pharma, came into existence in 1986. In 1991, the company was formed into a legal corporation. However, it actively started working as a fully integrated pharmaceutical company in 1995. Today, we have 11,000 employees and are heading towards a turnover of INR 50000 million. Our vast network includes 50 C&F agents and 7500+ stockists. We provide a wide range of products – Antibiotic, Antifungal, NSAIDs, Gastrointestinal, Anthelmintic, Cardiovascular, Dermal, Erectile Dysfunction, and several other categories – across the nation.
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Amara Labs

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About the Company : Amara Labs Pvt Ltd is a WHO-GMP certified manufacturing company wholly owned by a team of technocrats with working experience of more than 20 years in Multi-Nationals Companies lik...

Amara Labs Pvt Ltd is a WHO-GMP certified manufacturing company wholly owned by a team of technocrats with working experience of more than 20 years in Multi-Nationals Companies like Mylan and Cipla. We offer Active Pharmaceutical Ingredients, custom synthesis for Domestic, Intermediates for regulated markets with a key focus on new molecules. The manufacturing facility for production is equipped with an ability of producing Active Pharmaceutical Ingredients(API’s) in cGMP standards, with additional facilities of Pilot Plant with a full suite for scaling up and validation of new molecules
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About the Company : Aurore Life Sciences is a pure-play API manufacturer with a diverse portfolio of capabilities in delivering efficiencies to generic players globally. Founded in 2017 by a team with...

Aurore Life Sciences is a pure-play API manufacturer with a diverse portfolio of capabilities in delivering efficiencies to generic players globally. Founded in 2017 by a team with vast experience across the pharmaceutical value chain, the company is on a mission to become the most preferred partner for pharmaceuticals. At Aurore, we aim to push the boundaries to manufacture and deliver high quality products that can be relied upon by both customers and regulators. Our thrust on rapidly adding capabilities have led us to acquire, integrate and expand our reach across the geographies.
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About the Company : Bulat Pharmaceutical is a fast growing pharmaceutical company, founded in the year 2017, Bulat Pharmaceutical is engaged in the manufacturing and sales of high quality APIs and Int...

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About the Company : Harman Finochem Limited is a leading India-based Pharmaceutical Company which specializes in the manufacture and export of more than 45 Active Pharmaceutical Ingredients (APls) of ...

Harman Finochem Limited is a leading India-based Pharmaceutical Company which specializes in the manufacture and export of more than 45 Active Pharmaceutical Ingredients (APls) of which 10 are Essential Drugs as per the WHO Model List. We deliver top quality products to more than 35 countries across the globe. Harman Finochem ensures that its customers worldwide are delighted by receiving APl’s which are safe, efficient and of highest quality. We adhere to principles of cGmp and our team at all levels is committed to achieving this corporate excellence goal.
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Hetero Drugs

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Sacubitril

About the Company : Hetero is a research based global pharmaceutical company focused on development, manufacturing and marketing of Active Pharmaceutical Ingredients (APIs), Intermediate Chemicals & F...

Hetero is a research based global pharmaceutical company focused on development, manufacturing and marketing of Active Pharmaceutical Ingredients (APIs), Intermediate Chemicals & Finished Dosages. Ever since its establishment in 1993, Hetero showed a tradition of excellence and deep sense of commitment in developing cost effective processes to offer wide range of affordable drugs. Hetero is building on the strengths of vertical integration in discovery research, process chemistry, API manufacturing, formulation development and commercialization.
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LTD.","supplierCountry":"CHINA","foreign_port":"NA","customer":"MEDREICH","customerCountry":"INDIA","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"2130","totalValueFC":"10876.9","currency":"USD","unitRateINR":"178281","date":"06-Apr-2023","totalValueINR":"891405","totalValueInUsd":"10876.9","indian_port":"BANGALORE AIR","hs_no":"29349990","bill_no":"5405806","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"12\/8 SARASWATHI AMMAL STREET MARUTHI SEVA NAGAR Contact No: 9177"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1682533800,"product":"SACUBITRIL VALSARTAN NA HYDRATE\/DS11","address":"INSPIRE BKC PART OF 601 AND 701,BA NDRAKURLA COMPLEX BANDRA EAST","city":"MUMBAI,MAHARASHTRA","supplier":"NOVARTIS PHARMACEUTICALS CORPORATION","supplierCountry":"SWITZERLAND","foreign_port":"NA","customer":"NOVARTIS PHARMACEUTICALS CORPORATION","customerCountry":"INDIA","quantity":"5.00","actualQuantity":"5000","unit":"GMS","unitRateFc":"3.2","totalValueFC":"18982.4","currency":"CHF","unitRateINR":"311.1","date":"27-Apr-2023","totalValueINR":"1555676.38","totalValueInUsd":"18982.4","indian_port":"HYDERABAD AIR","hs_no":"29335990","bill_no":"5705202","productDescription":"API","marketType":"REGULATED MARKET","country":"SWITZERLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"INSPIRE BKC PART OF 601 AND 701,BA NDRAKURLA COMPLEX BANDRA EAST"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1686681000,"product":"SACUBITRIL SODIUM(AS PER INV)","address":"SURVEY NO.42, GADDAPOTHARAM,KAZIPA LLY IND AREA, SANGAREDDY DIST","city":"GADDAPOTHARAM HYD,TELANGANA","supplier":"ZHUHAI RUNDU PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"NA","customer":"ALFRED E TIEFENBACHER GMBH","customerCountry":"INDIA","quantity":"26.00","actualQuantity":"26","unit":"KGS","unitRateFc":"1500","totalValueFC":"39571.1","currency":"USD","unitRateINR":"125099.9","date":"14-Jun-2023","totalValueINR":"3252600.106","totalValueInUsd":"39571.1","indian_port":"HYDERABAD AIR","hs_no":"29349990","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"SURVEY NO.42, GADDAPOTHARAM,KAZIPA LLY IND AREA, SANGAREDDY DIST"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1695061800,"product":"SACUBITRIL CALCIUM,(112 DRUMS PACKED IN 28 PALLETS).","address":"7.1.77\/E\/1\/303, DHARAM KARAM ROAD","city":"HYDERABAD,A.P.","supplier":"ZHEJIANG RAYBOW PHARMCEUTICAL CO., LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"DIVIS LABORATORIES","customerCountry":"INDIA","quantity":"4339.00","actualQuantity":"4339","unit":"KGS","unitRateFc":"666.8","totalValueFC":"2926006.9","currency":"USD","unitRateINR":"55976.6","date":"19-Sep-2023","totalValueINR":"242882621","totalValueInUsd":"2926006.9","indian_port":"Vizag-DLL SEZ","hs_no":"29339990","bill_no":"1000816","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pellets","supplierPort":"SHANGHAI","supplierAddress":"N\/A","customerAddress":"7.1.77\/E\/1\/303, DHARAM KARAM ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1700245800,"product":"SACUBITRIL\/VALSARTAN SODIUM","address":"H.NO. 8-2-337,BESIDE TV9 OFFICE","city":"HYDERABAD ANDHRA PRADESH","supplier":"CHANGZHOU PHARMACEUTICAL FACTORY","supplierCountry":"CHINA","foreign_port":"SHANGHAI - PU DONG","customer":"DR. REDDY\\'S LABORATORIES","customerCountry":"INDIA","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"800","totalValueFC":"4039.8","currency":"USD","unitRateINR":"67280","date":"18-Nov-2023","totalValueINR":"336400","totalValueInUsd":"4039.8","indian_port":"Hyderabad Air","hs_no":"29339990","bill_no":"8831638","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI - PU DONG","supplierAddress":"NO.518, LAO DONG EAST ROAD, CHANGZHOU JIANGSU 213018, CHINA. Changzhou, , China China","customerAddress":"H.NO. 8-2-337,BESIDE TV9 OFFICE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1707071400,"product":"SACUBITRIL CALCIUM 20,(90 DRUMS PACKED IN 23 PALLETS).","address":"7.1.77\/E\/1\/303, DHARAM KARAM ROAD","city":"HYDERABAD,A.P.","supplier":"ZHEJIANG RAYBOW PHARMA","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"DIVIS LABORATORIES","customerCountry":"INDIA","quantity":"3482.00","actualQuantity":"3482","unit":"KGS","unitRateFc":"630.1","totalValueFC":"2223719.3","currency":"USD","unitRateINR":"52989.8","date":"05-Feb-2024","totalValueINR":"184510397","totalValueInUsd":"2223719.3","indian_port":"Vizag-DLL SEZ","hs_no":"29339990","bill_no":"1000128","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pellets","supplierPort":"SHANGHAI","supplierAddress":"NO.18,NANYANGSAN ROAD,LINHAI,TAIZHO U CITY,ZHEJIANG China","customerAddress":"7.1.77\/E\/1\/303, DHARAM KARAM ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1711564200,"product":"SACUBITRIL VALSARTAN TRI-SODIUM HEMIPENTAHYDRATE (CRYSTALLINE FORM). B\/N: 12210-211201 MFG. DT. 26\/12\/2021 RETEST DT. 25","address":"PLOT NO.5222, PHASE- IV,","city":"AHMEDABAD -","supplier":"ZHEJIANG TIANYU PHARMACEUTICAL CO., LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"UNISON PHARMACEUTICALS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"650","totalValueFC":"6575.5","currency":"USD","unitRateINR":"54600","date":"28-Mar-2024","totalValueINR":"546000","totalValueInUsd":"6575.5","indian_port":"Ahmedabad Air","hs_no":"29339990","bill_no":"2776694","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Crystalline","supplierPort":"SHANGHAI","supplierAddress":"JIANGKOU DEVELOPMENT ZONE HUANGYANTAIZHOU ZHEJIANG, CHINASDNF CHINA","customerAddress":"PLOT NO.5222, PHASE- IV,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1723141800,"product":"SACUBITRIL VALSARTAN NA HYDRATE\/DS11","address":"SANDOZ HOUSE,8TH FLOOR,","city":"MUMBAI,MAHARASHTRA","supplier":"NOVARTIS PHARMACEUTICALS CORPORATION","supplierCountry":"SWITZERLAND","foreign_port":"BASLE","customer":"NOVARTIS PHARMACEUTICALS CORPORATION","customerCountry":"INDIA","quantity":"35.00","actualQuantity":"35000","unit":"GMS","unitRateFc":"2.3","totalValueFC":"95645.7","currency":"CHF","unitRateINR":"229.2","date":"09-Aug-2024","totalValueINR":"8022618.52","totalValueInUsd":"95645.7","indian_port":"Hyderabad Air","hs_no":"29339990","bill_no":"4975785","productDescription":"API","marketType":"REGULATED MARKET","country":"SWITZERLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"BASLE","supplierAddress":"LICHSTRASE 35CH-4002 BASELSWITZERLAND CH","customerAddress":"SANDOZ HOUSE,8TH FLOOR,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1731349800,"product":"SACUBITRIL -VALSARTAN TRISODIUM (AMORPHOUS) IHS (D90 NMT 65MICRON) (DMF GRADE -MACLEODS) BATCH NO. E\/1236\/A22001SACUBITRIL -VALSARTAN TRISODIUM (AMORPHOUS) IHS (D90 NMT 65","address":"304,ATLANTA ARCADE,","city":"MUMBAI MAHARASHTRA","supplier":"MACLEODS PHARMACEUTICAL LTD.","supplierCountry":"INDIA","foreign_port":"INDORE(EPZ\/SEZ)","customer":"MACLEODS PHARMACEUTICALS LTD","customerCountry":"INDIA","quantity":"17.26","actualQuantity":"17.258","unit":"KGS","unitRateFc":"551.7","totalValueFC":"9612.8","currency":"USD","unitRateINR":"47004.7","date":"12-Nov-2024","totalValueINR":"811207","totalValueInUsd":"9612.8","indian_port":"Indore-EPZ\/SEZ","hs_no":"29339990","bill_no":"6636885","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"INDORE(EPZ\/SEZ)","supplierAddress":"PLOT NO. M-50 TO 54&54A, PHASE-II, INDORE SPECIAL ECONOMIC ZONE, PITHAMPUR, DIST. DHAR INDIA","customerAddress":"304,ATLANTA ARCADE,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1731695400,"product":"SACUBITRIL SODIUM (TEST LIC NO-SW\/OD\/11\/2024\/000005897 DT-25\/09\/2024)","address":"304,MOHAN PLACE,L.S.C.BLOCK-C","city":"DELHI","supplier":"ZHEJIANG TIANYU PHARMACEUTICAL CO., LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"AKUMS DRUGS & PHARMACEUTICALS LTD","customerCountry":"INDIA","quantity":"24.00","actualQuantity":"24","unit":"KGS","unitRateFc":"600","totalValueFC":"14555.6","currency":"USD","unitRateINR":"51180","date":"16-Nov-2024","totalValueINR":"1228320","totalValueInUsd":"14555.6","indian_port":"Delhi Air","hs_no":"29411090","bill_no":"6721211","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"JIANGKOU DEVELOPMENT ZONE HUANGYAN TAIZHOU ZHEJIANG ZHEJIANG, , CHINA SDNF CHINA","customerAddress":"304,MOHAN PLACE,L.S.C.BLOCK-C"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1732905000,"product":"SACUBITRIL SODIUM ( CAS NO : 149690-05-1 )(AS PER INVOICE)","address":"802, BLOCK-A, ALPINE HEIGHTS","city":"HYDERABAD, A.P.","supplier":"ZHEJIANG TIANYU PHARMACEUTICAL CO., LTD","supplierCountry":"CHINA","foreign_port":"N\/A","customer":"ALFRED E TIEFENBACHER GMBH","customerCountry":"INDIA","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"1200","totalValueFC":"6068.4","currency":"USD","unitRateINR":"102420","date":"30-Nov-2024","totalValueINR":"512100","totalValueInUsd":"6068.4","indian_port":"Hyderabad Air","hs_no":"29173990","bill_no":"6972741","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"JIANGKOU DEVELOPMENT ZONE HUANGYAN TAIZHOU ZHEJIANG China","customerAddress":"802, BLOCK-A, ALPINE HEIGHTS"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1736274600,"product":"SACUBITRIL CALCIUM 20","address":"7.1.77\/E\/1\/303, DHARAM KARAM ROAD","city":"HYDERABAD,A.P.","supplier":"ZHEJIANG RAYBOW PHARMA","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"DIVI'S LABORATORIES LIMITED","customerCountry":"INDIA","quantity":"5247.66","actualQuantity":"5247.66","unit":"KGS","unitRateFc":"529.3","totalValueFC":"2789530.6","currency":"USD","unitRateINR":"45837.4","date":"08-Jan-2025","totalValueINR":"240538985.53","totalValueInUsd":"2789530.6","indian_port":"Vizag-DLL SEZ","hs_no":"29339990","bill_no":"7674474","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"NO.18 NANYANGSAN ROAD ,DUQIAO LINHAI NANYANG SAN RD,TAIZHOU CITY SDNF China","customerAddress":"7.1.77\/E\/1\/303, DHARAM KARAM ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1739557800,"product":"SACUBITRIL SODIUM SACUBITRIL ISODIUM","address":"#28 CANTON ROWS, PETBASHEERBAD","city":"HYDERABAD","supplier":"ZHEJIANG TIANYU PHARMACEUTICAL CO., LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"AIZANT DRUG RESEARCH SOLUTIONS PVT. LTD.","customerCountry":"INDIA","quantity":"831.00","actualQuantity":"831","unit":"KGS","unitRateFc":"1950","totalValueFC":"1647206.2","currency":"USD","unitRateINR":"172380","date":"15-Feb-2025","totalValueINR":"143247780","totalValueInUsd":"1647206.2","indian_port":"Hyderabad Air","hs_no":"29339990","bill_no":"8384004","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"Jiangkou Development Zone Huangyan Taizhou Zhejiang China CN","customerAddress":"#28 CANTON ROWS, PETBASHEERBAD"}]
11-Feb-2021
17-Feb-2025
KGS
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Quantity (KGS) & Unit rate (USD/KGS) over time

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Drugs in Development

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Details:

Entresto-Generic (sacubitril and valsartan) is an oral angiotensin receptor neprilysin inhibitor, which is approved for the treatment of chronic heart failure.


Lead Product(s): Sacubitril Sodium,Valsartan

Therapeutic Area: Cardiology/Vascular Diseases Brand Name: Entresto-Generic

Study Phase: Approved FDFProduct Type: Other Small Molecule

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable January 24, 2025

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01

Lupin Ltd

India
arrow
Plastics Recycling EU
Not Confirmed

Lupin Ltd

India
arrow
Plastics Recycling EU
Not Confirmed

Details : Entresto-Generic (sacubitril and valsartan) is an oral angiotensin receptor neprilysin inhibitor, which is approved for the treatment of chronic heart failure.

Product Name : Entresto-Generic

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

January 24, 2025

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Details:

OnArni (sacubitril and valsartan) is an oral angiotensin receptor neprilysin inhibitor, which is approved for the treatment of chronic heart failure in 2 years and older patients.


Lead Product(s): Sacubitril Sodium,Valsartan

Therapeutic Area: Cardiology/Vascular Diseases Brand Name: OnArni

Study Phase: Approved FDFProduct Type: Other Small Molecule

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable October 15, 2024

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02

Plastics Recycling EU
Not Confirmed
Plastics Recycling EU
Not Confirmed

Details : OnArni (sacubitril and valsartan) is an oral angiotensin receptor neprilysin inhibitor, which is approved for the treatment of chronic heart failure in 2 years and older patients.

Product Name : OnArni

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

October 15, 2024

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Details:

Enresto-Generic (sacubitril and valsartan) is an oral neprilysin inhibitor, is approved for the treatment of additional indication of adults chronic heart failure.


Lead Product(s): Sacubitril Sodium,Valsartan

Therapeutic Area: Cardiology/Vascular Diseases Brand Name: Entresto-Generic

Study Phase: Approved FDFProduct Type: Other Small Molecule

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable October 07, 2024

blank

03

Plastics Recycling EU
Not Confirmed
Plastics Recycling EU
Not Confirmed

Details : Enresto-Generic (sacubitril and valsartan) is an oral neprilysin inhibitor, is approved for the treatment of additional indication of adults chronic heart failure.

Product Name : Entresto-Generic

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

October 07, 2024

blank

Details:

Entresto (sacubitril and valsartan) is an oral angiotensin receptor neprilysin inhibitor, which is approved for the treatment of additional indication of pediatric chronic heart failure.


Lead Product(s): Sacubitril Sodium,Valsartan

Therapeutic Area: Cardiology/Vascular Diseases Brand Name: Entresto

Study Phase: Approved FDFProduct Type: Other Small Molecule

Sponsor: Otsuka Pharmaceutical

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable September 02, 2024

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04

Plastics Recycling EU
Not Confirmed
Plastics Recycling EU
Not Confirmed

Details : Entresto (sacubitril and valsartan) is an oral angiotensin receptor neprilysin inhibitor, which is approved for the treatment of additional indication of pediatric chronic heart failure.

Product Name : Entresto

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

September 02, 2024

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Details:

A eneric formulation of sacubitril and valsartan, an oral neprilysin inhibitor, is approved for the treatment of additional indication of adults chronic heart failure.


Lead Product(s): Sacubitril Sodium,Valsartan

Therapeutic Area: Cardiology/Vascular Diseases Brand Name: Entresto-Generic

Study Phase: Approved FDFProduct Type: Other Small Molecule

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable May 29, 2024

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05

Interphex
Not Confirmed
Interphex
Not Confirmed

Details : A eneric formulation of sacubitril and valsartan, an oral neprilysin inhibitor, is approved for the treatment of additional indication of adults chronic heart failure.

Product Name : Entresto-Generic

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

May 29, 2024

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Details:

Sacubright (sacubitril and valsartan) is an oral angiotensin receptor neprilysin inhibitor, which is approved for the treatment of chronic heart failure in 2 years and older patients.


Lead Product(s): Sacubitril Sodium,Valsartan

Therapeutic Area: Cardiology/Vascular Diseases Brand Name: Sacubright

Study Phase: Phase IIProduct Type: Other Small Molecule

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable April 10, 2024

blank

06

Plastics Recycling EU
Not Confirmed
Plastics Recycling EU
Not Confirmed

Details : Sacubright (sacubitril and valsartan) is an oral angiotensin receptor neprilysin inhibitor, which is approved for the treatment of chronic heart failure in 2 years and older patients.

Product Name : Sacubright

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

April 10, 2024

blank

Details:

Entresto (sacubitril and valsartan) is an oral angiotensin receptor neprilysin inhibitor, which is approved for the treatment of additional indication of pediatric chronic heart failure.


Lead Product(s): Sacubitril Sodium,Valsartan

Therapeutic Area: Cardiology/Vascular Diseases Brand Name: Entresto

Study Phase: Approved FDFProduct Type: Other Small Molecule

Sponsor: Otsuka Pharmaceutical

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable March 26, 2024

blank

07

Plastics Recycling EU
Not Confirmed
Plastics Recycling EU
Not Confirmed

Details : Entresto (sacubitril and valsartan) is an oral angiotensin receptor neprilysin inhibitor, which is approved for the treatment of additional indication of pediatric chronic heart failure.

Product Name : Entresto

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

March 26, 2024

blank

Details:

Sacubitril and valsartan is an oral angiotensin receptor neprilysin inhibitor, which is approved for the treatment of chronic heart failure in 2 years and older patients.


Lead Product(s): Sacubitril Sodium,Valsartan

Therapeutic Area: Cardiology/Vascular Diseases Brand Name: Entresto-Generic

Study Phase: Approved FDFProduct Type: Other Small Molecule

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable February 09, 2024

blank

08

Biocon

India
arrow
Plastics Recycling EU
Not Confirmed

Biocon

India
arrow
Plastics Recycling EU
Not Confirmed

Details : Sacubitril and valsartan is an oral angiotensin receptor neprilysin inhibitor, which is approved for the treatment of chronic heart failure in 2 years and older patients.

Product Name : Entresto-Generic

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

February 09, 2024

blank

Details:

Entresto contains a neprilysin inhibitor, sacubitril, and an angiotensin receptor blocker, valsartan. It inhibits neprilysin via LBQ657, the active metabolite of the prodrug sacubitril, and blocks the angiotensin II type-1 receptor via valsartan in pediatric heart failure.


Lead Product(s): Sacubitril Sodium,Valsartan

Therapeutic Area: Cardiology/Vascular Diseases Brand Name: Entresto

Study Phase: Approved FDFProduct Type: Other Small Molecule

Sponsor: Otsuka Pharmaceutical

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable March 31, 2023

blank

09

Plastics Recycling EU
Not Confirmed
Plastics Recycling EU
Not Confirmed

Details : Entresto contains a neprilysin inhibitor, sacubitril, and an angiotensin receptor blocker, valsartan. It inhibits neprilysin via LBQ657, the active metabolite of the prodrug sacubitril, and blocks the angiotensin II type-1 receptor via valsartan in pedia...

Product Name : Entresto

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

March 31, 2023

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Details:

Sacubitril and Valsartan drug inhibits neprilysin and blocks angiotensin II type-I receptor, increasing the levels of peptides degraded by neprilysin. It is indicated to reduce the risk of cardiovascular death and hospitalization for heart failure.


Lead Product(s): Sacubitril Sodium,Valsartan

Therapeutic Area: Cardiology/Vascular Diseases Brand Name: Valentas

Study Phase: Approved FDFProduct Type: Other Small Molecule

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable January 18, 2023

blank

10

Lupin Ltd

India
arrow
Plastics Recycling EU
Not Confirmed

Lupin Ltd

India
arrow
Plastics Recycling EU
Not Confirmed

Details : Sacubitril and Valsartan drug inhibits neprilysin and blocks angiotensin II type-I receptor, increasing the levels of peptides degraded by neprilysin. It is indicated to reduce the risk of cardiovascular death and hospitalization for heart failure.

Product Name : Valentas

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

January 18, 2023

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Full Screen ViewFULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

Europe

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01

Country
Interphex
Not Confirmed
arrow

Country
arrow
Interphex
Not Confirmed

Valsartan; Sacubitril Sodium

Brand Name : 56 Neparvis 97/103Mg Film-Coated Tablets

Dosage Form : Film Coated Tablet

Dosage Strength :

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Spain

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02

Country
Interphex
Not Confirmed
arrow

Country
arrow
Interphex
Not Confirmed

Valsartan; Sacubitril Sodium

Brand Name : 56 Entresto 97/103Mg Film-Coated Tablets

Dosage Form : Film Coated Tablet

Dosage Strength :

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Spain

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03

Country
Interphex
Not Confirmed
arrow

Country
arrow
Interphex
Not Confirmed

Valsartan; Sacubitril Sodium

Brand Name : 28 Entresto 24/26Mg Film-Coated Tablets

Dosage Form : Film Coated Tablet

Dosage Strength :

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Spain

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04

Country
Interphex
Not Confirmed
arrow

Country
arrow
Interphex
Not Confirmed

Sacubitril Sodium; Valsartan

Brand Name : 28 Neparvis 24/26Mg Film-Coated Tablets

Dosage Form : Film Coated Tablet

Dosage Strength :

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Spain

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05

Country
Interphex
Not Confirmed
arrow

Country
arrow
Interphex
Not Confirmed

Sacubitril Sodium; Valsartan

Brand Name : 56 Entresto 49/51Mg Film-Coated Tablets

Dosage Form : Film Coated Tablet

Dosage Strength :

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Spain

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Interphex
Not Confirmed
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Interphex
Not Confirmed

Sacubitril Sodium; Valsartan

Brand Name : 56 Neparvis 49/51Mg Film-Coated Tablets

Dosage Form : Film Coated Tablet

Dosage Strength :

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Spain

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South Africa

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Novartis South Africa (Pty) Ltd

Country
Plastics Recycling EU
Not Confirmed
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Novartis South Africa (Pty) Ltd

Country
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Plastics Recycling EU
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Sacubitril

Brand Name : Vymada 50 mg

Dosage Form : TAB

Dosage Strength : 24mg

Packaging : 28X1mg

Approval Date :

Application Number :

Regulatory Info : Generic

Registration Country : South Africa

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02

Novartis South Africa (Pty) Ltd

Country
Plastics Recycling EU
Not Confirmed
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Novartis South Africa (Pty) Ltd

Country
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Plastics Recycling EU
Not Confirmed

Sacubitril

Brand Name : Vymada 100 mg

Dosage Form : TAB

Dosage Strength : 49mg

Packaging : 28X1mg

Approval Date :

Application Number :

Regulatory Info : Generic

Registration Country : South Africa

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03

Novartis South Africa (Pty) Ltd

Country
Plastics Recycling EU
Not Confirmed
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Novartis South Africa (Pty) Ltd

Country
arrow
Plastics Recycling EU
Not Confirmed

Sacubitril

Brand Name : Vymada 200 mg

Dosage Form : TAB

Dosage Strength : 97mg

Packaging : 28X1mg

Approval Date :

Application Number :

Regulatory Info : Generic

Registration Country : South Africa

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ABOUT THIS PAGE

Looking for 149690-05-1 / Sacubitril Sodium API manufacturers, exporters & distributors?

Sacubitril Sodium manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Sacubitril Sodium API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Sacubitril Sodium manufacturer or Sacubitril Sodium supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Sacubitril Sodium manufacturer or Sacubitril Sodium supplier.

PharmaCompass also assists you with knowing the Sacubitril Sodium API Price utilized in the formulation of products. Sacubitril Sodium API Price is not always fixed or binding as the Sacubitril Sodium Price is obtained through a variety of data sources. The Sacubitril Sodium Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Sacubitril Sodium

Synonyms

149690-05-1, Ahu-377 sodium, Sacubitril (sodium), Mop72gep8z, Sodium;4-[[(2s,4r)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoate, Unii-mop72gep8z

Cas Number

149690-05-1

Unique Ingredient Identifier (UNII)

MOP72GEP8Z

Sacubitril Sodium Manufacturers

A Sacubitril Sodium manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Sacubitril Sodium, including repackagers and relabelers. The FDA regulates Sacubitril Sodium manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Sacubitril Sodium API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Sacubitril Sodium manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Sacubitril Sodium Suppliers

A Sacubitril Sodium supplier is an individual or a company that provides Sacubitril Sodium active pharmaceutical ingredient (API) or Sacubitril Sodium finished formulations upon request. The Sacubitril Sodium suppliers may include Sacubitril Sodium API manufacturers, exporters, distributors and traders.

click here to find a list of Sacubitril Sodium suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Sacubitril Sodium USDMF

A Sacubitril Sodium DMF (Drug Master File) is a document detailing the whole manufacturing process of Sacubitril Sodium active pharmaceutical ingredient (API) in detail. Different forms of Sacubitril Sodium DMFs exist exist since differing nations have different regulations, such as Sacubitril Sodium USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Sacubitril Sodium DMF submitted to regulatory agencies in the US is known as a USDMF. Sacubitril Sodium USDMF includes data on Sacubitril Sodium's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Sacubitril Sodium USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Sacubitril Sodium suppliers with USDMF on PharmaCompass.

Sacubitril Sodium WC

A Sacubitril Sodium written confirmation (Sacubitril Sodium WC) is an official document issued by a regulatory agency to a Sacubitril Sodium manufacturer, verifying that the manufacturing facility of a Sacubitril Sodium active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Sacubitril Sodium APIs or Sacubitril Sodium finished pharmaceutical products to another nation, regulatory agencies frequently require a Sacubitril Sodium WC (written confirmation) as part of the regulatory process.

click here to find a list of Sacubitril Sodium suppliers with Written Confirmation (WC) on PharmaCompass.

Sacubitril Sodium NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Sacubitril Sodium as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Sacubitril Sodium API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Sacubitril Sodium as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Sacubitril Sodium and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Sacubitril Sodium NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Sacubitril Sodium suppliers with NDC on PharmaCompass.

Sacubitril Sodium GMP

Sacubitril Sodium Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Sacubitril Sodium GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Sacubitril Sodium GMP manufacturer or Sacubitril Sodium GMP API supplier for your needs.

Sacubitril Sodium CoA

A Sacubitril Sodium CoA (Certificate of Analysis) is a formal document that attests to Sacubitril Sodium's compliance with Sacubitril Sodium specifications and serves as a tool for batch-level quality control.

Sacubitril Sodium CoA mostly includes findings from lab analyses of a specific batch. For each Sacubitril Sodium CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Sacubitril Sodium may be tested according to a variety of international standards, such as European Pharmacopoeia (Sacubitril Sodium EP), Sacubitril Sodium JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Sacubitril Sodium USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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