Please Wait
Applying Filters...
menu
    • menu
    Granules India Limited has high volume world-class facilities for APIs, PFIs, & FDFs, serving customers in over 80 countries.

    Virtual Booth

    Contact Supplier

    Jai Radhe Sales is your partner for all your sourcing needs.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2024-10-07

    Virtual Booth

    Contact Supplier

    Egis is a Hungarian generic pharma company with 110 years history. Our activities incorporate all areas of the pharma value chain.

    Virtual Booth

    Contact Supplier

    Biophore is a research-driven global pharmaceutical company focused on niche APIs for the generic industry.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2024-10-07

    Virtual Booth

    Contact Supplier

    Menu

    1-Beta-D-Arabinofuranosylcytosine Hydrochloride

    BUILDING BLOCK

    PharmaCompass
    Xls

    Filters

    clear-filterReset all filters
    2D Structure
    Also known as: Cytarabin, 4-amino-1-pentofuranosylpyrimidin-2(1h)-one, .beta.-arabinosylcytosine, .beta.-cytosine arabinoside, .beta.-d-arabinosylcytosine, Cytosine-.beta.-arabinoside
    Molecular Formula
    C9H13N3O5
    Molecular Weight
    243.22  g/mol
    InChI Key
    UHDGCWIWMRVCDJ-UHFFFAOYSA-N
    A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    4-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
    2.1.2 InChI
    InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)
    2.1.3 InChI Key
    UHDGCWIWMRVCDJ-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Ara C

    2. Ara-c

    3. Arabinofuranosylcytosine

    4. Arabinoside, Cytosine

    5. Arabinosylcytosine

    6. Aracytidine

    7. Aracytine

    8. Beta Ara C

    9. Beta-ara C

    10. Cytarabine

    11. Cytarabine Hydrochloride

    12. Cytonal

    13. Cytosar U

    14. Cytosar-u

    15. Cytosine Arabinoside

    2.2.2 Depositor-Supplied Synonyms

    1. Cytarabin

    2. 4-amino-1-pentofuranosylpyrimidin-2(1h)-one

    3. .beta.-arabinosylcytosine

    4. .beta.-cytosine Arabinoside

    5. .beta.-d-arabinosylcytosine

    6. Cytosine-.beta.-arabinoside

    7. Arabinofuranosylcytosine

    8. Aracytidine

    9. Cytarabinoside

    10. Spongocytidine

    11. 1.beta.-d-arabinosylcytosine

    12. Alexan

    13. Mls003389283

    14. Cytosine, .beta.-d-arabinoside

    15. 1.beta.-arabinofuranasylcytosine

    16. Arabinosylcytosine

    17. Cytosine Arabinose

    18. Nci-c04728

    19. 1.beta.-d-arabinofuranosylcytosine

    20. 4-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

    21. Cytosine, 1-.beta.-d-arabinosyl-

    22. Cytosine-.beta.-d-arabinofuranoside

    23. 1-.beta.-d-arabinofaranosylcytosine

    24. Cylocide

    25. Nsc 63878

    26. Cytosine, 1-.beta.-d-arabinofuranosyl-

    27. 1-arabinofuranosylcytosine

    28. 4-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1h)-one

    29. Cytarabina

    30. Arabitin

    31. Arafcyt

    32. Erpalfa

    33. 688007-26-3

    34. Iretin

    35. 1-.beta.-d-arabinofuranosyl-4-amino-2(1h)pyrimidinone

    36. Cytosine-beta-d-arabinofuranoside

    37. Cytosine Beta-d-riboside;cytosine-1-beta-d-ribofuranoside

    38. Cytosine Beta-d-arabinofuranoside;cytosine Arabinoside;ara-c

    39. Mls002702869

    40. 4-amino-1-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1h)-one

    41. Cytosine Beta-d-arabinofuranoside Hydrochloride;cytosine Arabinoside Hydrochloride;ara-c Hydrochloride

    42. Smr001549941

    43. 1.beta.-ribofuranosylcytosine

    44. 1.beta.-d-ribofuranosylcytosine

    45. 4-amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidine

    46. 1-.beta.-d-arabinofuranosylcytosine

    47. U 19920

    48. Mfcd00006545

    49. Mfcd00066487

    50. Nsc287459

    51. .beta.-d-ribofuranoside, Cytosine-1

    52. Cytarabine, Cytarabine (cytosine 1-b-d-arabinofuranoside), Cytidine

    53. Cytosine, 1-.beta.-d-ribofuranosyl-

    54. Ac-1075

    55. Nsc 287459

    56. Ac 1075

    57. Chembl78

    58. 4-amino-1.beta.-d-ribofuranosyl-2(1h)-pyrimidinone

    59. Chemdiv1_027335

    60. Molmap_000003

    61. 2(1h)-pyrimidinone, 4-amino-1-.beta.-d-ribofuranosyl-

    62. Oprea1_593929

    63. Oprea1_858801

    64. Schembl149563

    65. Cytosine .beta.-d-arabinoside

    66. 1-(b-d-xylofuranosyl)cytosine

    67. Hms664k11

    68. Dtxsid80859078

    69. 1-.beta.-arabinofuranosylcytosine

    70. 1-.beta.-d-ribofuranosylcytosine

    71. Hms3371g12

    72. Hms3393k19

    73. Hms3428o03

    74. Hms3655p13

    75. Albb-021997

    76. Chx-3311

    77. Nsc20258

    78. Bbl028243

    79. Nsc249004

    80. Stk391124

    81. Akos001590380

    82. Akos017259253

    83. Cytosine-1-.beta.-d-arabinofuranoside

    84. Nsc-249004

    85. Smp2_000209

    86. Ncgc00015258-02

    87. Ncgc00015258-03

    88. Ncgc00015258-04

    89. Ncgc00015258-05

    90. Ncgc00094638-01

    91. Ncgc00094638-02

    92. Ncgc00094638-03

    93. Ncgc00094638-04

    94. As-12090

    95. Nci60_012951

    96. Sy004943

    97. Sy005417

    98. Db-124991

    99. U-19920 A

    100. Ft-0624314

    101. Ft-0624315

    102. Ft-0774114

    103. Wln: T6nvnj Dz A-bt5otj Cq Dq E1q

    104. Ab01273973-01

    105. L001298

    106. Sr-01000597029

    107. Sr-01000597029-1

    108. 2(1h)-pyrimidinone, 4-amino-1.beta.-d-ribofuranosyl-

    109. 4-amino-1-.beta.-d-arabinofuranosyl-2(1h)-pyrimidinon

    110. 4-amino-1-.beta.-d-arabinofuranosyl-2(1h)-pyrimidinone

    111. 2(1h)-pyrimidinone, 4-amino-1.beta.-d-arabinofuranosyl-

    2.3 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 243.22 g/mol
    Molecular Formula C9H13N3O5
    XLogP3-2.1
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count2
    Exact Mass243.08552052 g/mol
    Monoisotopic Mass243.08552052 g/mol
    Topological Polar Surface Area129 Ų
    Heavy Atom Count17
    Formal Charge0
    Complexity383
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count4
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antiviral Agents

    Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)

    Antimetabolites, Antineoplastic

    Antimetabolites that are useful in cancer chemotherapy. (See all compounds classified as Antimetabolites, Antineoplastic.)

    Immunosuppressive Agents

    Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging. (See all compounds classified as Immunosuppressive Agents.)