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    138-37-4

    PharmaCompass
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    2D Structure
    Also known as: 138-37-4, 4-aminomethylbenzenesulfonamide hydrochloride, 4-(aminomethyl)benzenesulfonamide hydrochloride, Marfanil, Masudin, Morfanil
    Molecular Formula
    C7H11ClN2O2S
    Molecular Weight
    222.69  g/mol
    InChI Key
    SIACJRVYIPXFKS-UHFFFAOYSA-N
    FDA UNII
    3J751V0284
    A sulfonamide that inhibits the enzyme CARBONIC ANHYDRASE and is used as a topical anti-bacterial agent, especially in burn therapy.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    4-(aminomethyl)benzenesulfonamide;hydrochloride
    2.1.2 InChI
    InChI=1S/C7H10N2O2S.ClH/c8-5-6-1-3-7(4-2-6)12(9,10)11;/h1-4H,5,8H2,(H2,9,10,11);1H
    2.1.3 InChI Key
    SIACJRVYIPXFKS-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1=CC(=CC=C1CN)S(=O)(=O)N.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    3J751V0284
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 4 Homosulfanilamide

    2. 4-homosulfanilamide

    3. Bensulfamide

    4. Mafenide

    5. Mafenide Acetate

    6. Mafylon

    7. Maphenid

    8. Marfanil

    9. Napaltan

    10. Sulfabenzamine

    11. Sulfamylon

    2.3.2 Depositor-Supplied Synonyms

    1. 138-37-4

    2. 4-aminomethylbenzenesulfonamide Hydrochloride

    3. 4-(aminomethyl)benzenesulfonamide Hydrochloride

    4. Marfanil

    5. Masudin

    6. Morfanil

    7. Homosulfamine Hydrochloride

    8. Mesudin Hydrochloride

    9. Ambamide Hydrochloride

    10. Mafenide Hcl

    11. Homosulfamine

    12. 4-homosulfanilamide Hydrochloride

    13. Sulfamylon Hydrochloride

    14. Sulfbenzamine Hydrochloride

    15. Homosulfanilamide Hydrochloride

    16. Mafenide (hydrochloride)

    17. Benzenesulfonamide, 4-(aminomethyl)-, Monohydrochloride

    18. P-aminomethylphenylsulfonamide Hydrochloride

    19. Alpha-amino-p-toluenesulfonamide Hydrochloride

    20. Nsc-3527

    21. P-(aminomethyl)benzenesulfonamide Hydrochloride

    22. Mfcd00013005

    23. P-(aminomethyl)benzenesulfonamide Monohydrochloride

    24. 4-(aminomethyl)benzenesulfonamide;hydrochloride

    25. 49783-80-4

    26. Emilene Hydrochloride

    27. 3j751v0284

    28. 4-(aminomethyl)benzenesulfonamide Hcl

    29. Dsstox_cid_25296

    30. Dsstox_rid_80787

    31. Dsstox_gsid_45296

    32. Mesudrin Hydrochloride

    33. Neofamid Hydrochloride

    34. Maphenide Hydrochloride

    35. Benzenesulfonamide, 4-(aminomethyl)-, Hydrochloride (1:)

    36. Ncgc00016403-01

    37. Nsc 3527

    38. Cas-138-37-4

    39. Einecs 205-325-3

    40. Ai3-16157

    41. Sr-01000003113

    42. 4-(aminomethyl)benzene-1-sulfonamide Hydrochloride

    43. Unii-3j751v0284

    44. P-toluenesulfonamide, Alpha-amino-, Hydrochloride

    45. Prestwick_640

    46. 4-(aminomethyl)benzenesulfonamidehydrochloride

    47. Mafenide Hcl [inci]

    48. Mls002222235

    49. Schembl425524

    50. Spectrum1500372

    51. P-toluenesulfonamide, Alpha-amino-, Monohydrochloride

    52. Wln: Zswr D1z & Gh

    53. Chembl1593568

    54. Dtxsid6045296

    55. Hy-b0614b

    56. Nsc3527

    57. Hms1568b13

    58. Hms1920j11

    59. P-toluenesulfonamide, Hydrochloride

    60. Pharmakon1600-01500372

    61. Mafenide Hydrochloride [mi]

    62. 4-sulfamoylbenzylamine Hydrochloride

    63. Bcp03071

    64. 4-aminomethylbenzenesulfonamide, Hcl

    65. Tox21_110423

    66. Ccg-39706

    67. Nsc757093

    68. S3697

    69. Akos008967290

    70. P-toluenesulfonamide, Monohydrochloride

    71. Tox21_110423_1

    72. 4-aminosulfonylbenzylamine Hydrochloride

    73. Cs-4481

    74. Gs-4340

    75. Mafenide Hydrochloride [who-dd]

    76. Nsc-757093

    77. Ncgc00016403-06

    78. Ncgc00094711-01

    79. Ncgc00094711-02

    80. Ncgc00094711-03

    81. Ncgc00094711-04

    82. Ac-29745

    83. Smr001307253

    84. Sy020868

    85. 4-(aminosulfonyl)-benzylamine Hydrochloride

    86. Db-087235

    87. Am20060505

    88. Ft-0631805

    89. H0522

    90. P-aminomethyl-benzenesulfonamide Hydrochloride

    91. 4-aminomethyl-benzenesulfonamide Hydrochloride

    92. P-aminomethyl Benzene Sulfonamide Hydrochloride

    93. O11078

    94. .alpha.-amino-p-toluenesulfonamide Hydrochloride

    95. 4-(aminomethyl)benzene-sulfonamide Hydrochloride

    96. A807380

    97. J-007128

    98. J-521664

    99. Sr-01000003113-4

    100. 4-(aminomethyl)benzenesulfonamide Hydrochloride (1:1)

    101. Q27257294

    102. F0856-0073

    103. P-toluenesulfonamide, .alpha.-amino-, Monohydrochloride

    104. Benzenesulfonamide, 4-(aminomethyl)-, Hydrochloride (1:?)

    105. 4-aminomethylbenzenesulfonamide Hydrochloride, Analytical Standard, >=95%

    106. 4-(aminomethyl)benzenesulfonamide Hydrochloride;4-aminomethylbenzenesulfonamide Hydrochloride

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 222.69 g/mol
    Molecular Formula C7H11ClN2O2S
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count2
    Exact Mass222.0229765 g/mol
    Monoisotopic Mass222.0229765 g/mol
    Topological Polar Surface Area94.6 Ų
    Heavy Atom Count13
    Formal Charge0
    Complexity224
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-Infective Agents, Local

    Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects. (See all compounds classified as Anti-Infective Agents, Local.)

    Anti-Bacterial Agents

    Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

    Carbonic Anhydrase Inhibitors

    A class of compounds that reduces the secretion of H+ ions by the proximal kidney tubule through inhibition of CARBONIC ANHYDRASES. (See all compounds classified as Carbonic Anhydrase Inhibitors.)