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2D Structure
Also known as: 3605-01-4, Trivastal, Trivastan, 2-(4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)pyrimidine, Et-495, Eu-4200
Molecular Formula
C16H18N4O2
Molecular Weight
298.34  g/mol
InChI Key
OQDPVLVUJFGPGQ-UHFFFAOYSA-N
FDA UNII
DO22K1PRDJ

A dopamine D2 agonist. It is used in the treatment of parkinson disease, particularly for alleviation of tremor. It has also been used for circulatory disorders and in other applications as a D2 agonist.
1 2D Structure

2D Structure

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine
2.1.2 InChI
InChI=1S/C16H18N4O2/c1-4-17-16(18-5-1)20-8-6-19(7-9-20)11-13-2-3-14-15(10-13)22-12-21-14/h1-5,10H,6-9,11-12H2
2.1.3 InChI Key
OQDPVLVUJFGPGQ-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1CN(CCN1CC2=CC3=C(C=C2)OCO3)C4=NC=CC=N4
2.2 Other Identifiers
2.2.1 UNII
DO22K1PRDJ
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Et 495

2. Et-495

3. Et495

4. Eu 4200

5. Eu-4200

6. Eu4200

7. Hydrochloride, Piribedil

8. Mesylate, Piribedil

9. Mono-hydrochloride, Piribedil

10. Piribedil Hydrochloride

11. Piribedil Mesylate

12. Piribedil Mono Hydrochloride

13. Piribedil Mono-hydrochloride

14. Piribendyl

15. Trivastal

2.3.2 Depositor-Supplied Synonyms

1. 3605-01-4

2. Trivastal

3. Trivastan

4. 2-(4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)pyrimidine

5. Et-495

6. Eu-4200

7. Et 495

8. 2-(4-piperonyl-1-piperazinyl)pyrimidine

9. 2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine

10. Eu 4200

11. Do22k1prdj

12. 1-(2-pyrimidyl)-4-piperonylpiperazine

13. Pyrimidine, 2-(4-piperonyl-1-piperazinyl)-

14. Pyrimidine, 2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-

15. Piribedil (inn)

16. 2-(4-(3,4-methylenedioxybenzyl)piperazino)pyrimidine

17. 1-(3,4-methylenedioxybenzyl)-4-(2-pyrimidyl)piperazine

18. Ncgc00015857-05

19. 2-(4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl)pyrimidine

20. 2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine

21. Piribedil [inn]

22. Pyrimidine, 2-(4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl)-

23. Dsstox_cid_25188

24. Dsstox_rid_80735

25. Dsstox_gsid_45188

26. 2-[4-(2h-1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine

27. Cas-3605-01-4

28. Piribedile [dcit]

29. Piribedil [inn:dcf]

30. Piribedilum [inn-latin]

31. Piribedile

32. Piribedilum

33. Sr-01000076091

34. Trivastal (tn)

35. Einecs 222-764-6

36. Brn 0963637

37. Tocris-1031

38. Piribedil [mi]

39. Prestwick0_000980

40. Prestwick1_000980

41. Prestwick2_000980

42. Prestwick3_000980

43. Unii-do22k1prdj

44. Lopac-p-9233

45. Biomol-nt_000044

46. Gtpl49

47. Piribedil [mart.]

48. Cambridge Id 5268291

49. Piribedil [who-dd]

50. Lopac0_000965

51. Oprea1_061309

52. Oprea1_215383

53. Bspbio_001019

54. Schembl150101

55. Spbio_002930

56. Bpbio1_001121

57. Bpbio1_001269

58. Chembl1371770

59. Dtxsid9045188

60. Bdbm85092

61. Chebi:92833

62. 2-(4-benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-pyrimidine

63. Hms2089m17

64. Hms3885e19

65. Bcp10553

66. Nsc_4850

67. Tox21_110245

68. Mfcd00868264

69. S3656

70. Stl497889

71. Zinc19537374

72. Akos001309525

73. Tox21_110245_1

74. Ac-1051

75. Ccg-205045

76. Cs-8014

77. Db12478

78. Es-0016

79. Sdccgsbi-0050938.p003

80. Ncgc00015857-01

81. Ncgc00015857-02

82. Ncgc00015857-03

83. Ncgc00015857-04

84. Ncgc00015857-06

85. Ncgc00015857-07

86. Ncgc00015857-09

87. Ncgc00015857-16

88. Ncgc00024951-01

89. Ncgc00024951-02

90. Ncgc00024951-03

91. Hy-12707

92. Cas_3605-01-4

93. Sbi-0050938.p002

94. Cas-78213-63-5

95. Ab00514645

96. Ft-0610865

97. P2054

98. 2,5-diamino-4-(dimethylamino)-4-nitrostilbene

99. D07305

100. T72361

101. Ab00514645-19

102. 605p014

103. A823101

104. L000476

105. Q413976

106. Brd-k47936004-001-01-9

107. Brd-k47936004-003-03-1

108. Sr-01000076091-11

109. Z31240640

110. 1-(2-pyrimidyl)-4-(3,4-methylenedioxybenzyl)piperazine

111. 2-{4-[(1,3-benzodioxol-5-yl)methyl]piperazin-1-yl}pyrimidine

112. 2-{4-[(2h-1,3-benzodioxol-5-yl)methyl]piperazin-1-yl}pyrimidine

113. 2-(4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)pyrimidine Methanesulfonate

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 298.34 g/mol
Molecular Formula C16H18N4O2
XLogP31.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass298.14297583 g/mol
Monoisotopic Mass298.14297583 g/mol
Topological Polar Surface Area50.7 Ų
Heavy Atom Count22
Formal Charge0
Complexity356
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antiparkinson Agents

Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists. (See all compounds classified as Antiparkinson Agents.)


Dopamine Agonists

Drugs that bind to and activate dopamine receptors. (See all compounds classified as Dopamine Agonists.)


4.2 ATC Code

N04BC08

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


N - Nervous system

N04 - Anti-parkinson drugs

N04B - Dopaminergic agents

N04BC - Dopamine agonists

N04BC08 - Piribedil