1. 2-butanone
2. Ethyl Methyl Ketone
3. Methylethyl Ketone
1. 2-butanone
2. Butan-2-one
3. Butanone
4. 78-93-3
5. Ethyl Methyl Ketone
6. Methylethyl Ketone
7. Meetco
8. Methyl Acetone
9. Methylethylketone
10. 3-butanone
11. Ethylmethylketon
12. Ethylmethylketone
13. Aethylmethylketon
14. Butanone 2
15. Acetone, Methyl-
16. Mek
17. Ethyl Methyl Cetone
18. Ketone, Ethyl Methyl
19. Metiletilchetone
20. Metyloetyloketon
21. 2-butanon
22. Ethylmethyl Ketone
23. Rcra Waste Number U159
24. Fema No. 2170
25. Oxobutane
26. Methylethylketon
27. Methyl Ethylketone
28. Mfcd00011648
29. 6pt9klv9io
30. 2-butanone, Hplc Grade
31. C2h5coch3
32. Chebi:28398
33. Metyl Ethyl Ketone
34. Caswell No. 569
35. Butanone 2 [french]
36. Methylacetone
37. Metiletilcetona
38. Ethylmethylketon [dutch]
39. Ethylmethylcetone
40. Metiletilcetona [spanish]
41. Metyloetyloketon [polish]
42. Aethylmethylketon [german]
43. Ethylmethylcetone [french]
44. Metiletilchetone [italian]
45. 2-butanone, Acs Reagent, >=99.0%
46. Methyl-ethyl Ketone
47. Hsdb 99
48. Ethyl Methyl Cetone [french]
49. Methyl(ethyl) Ketone
50. Ccris 2051
51. Ai3-07540 (usda)
52. Einecs 201-159-0
53. Unii-6pt9klv9io
54. Un1193
55. Rcra Waste No. U159
56. Epa Pesticide Chemical Code 044103
57. N-butanone
58. Ai3-07540
59. 2-butanal
60. 2-oxobutane
61. Ethyl Methylketone
62. Ethylmathyl Ketone
63. Methyl-ethylketone
64. Methylethyl-ketone
65. Butane-2-one
66. 2 -butanone
67. 2- Butanone
68. Butan-3-one
69. Methyl Etyl Ketone
70. Ethyl-methyl Ketone
71. Methyl Ethyl Cetone
72. Methyl-ethyl-ketone
73. Ethyl(methyl) Ketone
74. Ketone, Methyl Ethyl
75. 2-butanone, Acs Grade
76. Dsstox_cid_1516
77. Mek [inci]
78. 2-butanone [fcc]
79. Ec 201-159-0
80. 2-butanone [fhfi]
81. Dsstox_rid_76193
82. Dsstox_gsid_21516
83. Ghl.pd_mitscher_leg0.417
84. Astm-d740
85. Chembl15849
86. 2-butanone, Analytical Standard
87. 2-butanone, Lr, >=99%
88. Dtxsid3021516
89. Methyl Ethyl Ketone - Mil Spec
90. Methyl Ethyl Ketone [ii]
91. Methyl Ethyl Ketone [mi]
92. Methyl Ethyl Ketone, Acs Reagent
93. Zinc901514
94. Methyl Ethyl Ketone [hsdb]
95. 2-butanone, Ar, >=99.5%
96. Methyl Ethyl Ketone [vandf]
97. 2-butanone, Technical Grade, 99%
98. Methyl Ethyl Ketone [mart.]
99. Tox21_200041
100. Lmfa12000043
101. Stl146562
102. 2-butanone, Natural, >=99%, Fg
103. Methyl Ethyl Ketone [usp-rs]
104. Akos000118991
105. 2-butanone, For Hplc, >=99.7%
106. Methyl Ethyl Ketone Reagent Grade Acs
107. Un 1193
108. 2-butanone, Puriss., >=99% (gc)
109. 2-butanone, Reagentplus(r), >=99%
110. Cas-78-93-3
111. 2-butanone, >=99.5%, Fcc, Fg
112. Ncgc00090973-01
113. Ncgc00090973-02
114. Ncgc00257595-01
115. Bp-30009
116. 2-butanone 100 Microg/ml In Acetonitrile
117. Ethyl Methyl Ketone Or Methyl Ethyl Ketone
118. 2-butanone, Saj First Grade, >=99.0%
119. 2-butanone, Jis Special Grade, >=99.0%
120. E0140
121. Ft-0628728
122. C02845
123. 2-butanone, Hplc Grade, For Hplc, >=99.5%
124. A839534
125. Q372291
126. 2-butanone, Puriss., Acs Reagent, Reag. Ph. Eur., 99.5%
127. 2-butanone, 5000 Mug/ml In Methanol: Water (9:1), Analytical Standard
128. 2-butanone, Puriss. P.a., Acs Reagent, Reag. Ph. Eur., >=99.5% (gc)
129. Ethyl Methyl Ketone Or Methyl Ethyl Ketone [un1193] [flammable Liquid]
130. Methyl Ethyl Ketone, United States Pharmacopeia (usp) Reference Standard
131. 2-butanone Solution, Certified Reference Material, 2000 Mug/ml In Methanol: Water (9:1)
132. Methyl Ethyl Ketone, Pharmaceutical Secondary Standard; Certified Reference Material
| Molecular Weight | 72.11 g/mol |
|---|---|
| Molecular Formula | C4H8O |
| XLogP3 | 0.3 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 1 |
| Exact Mass | 72.057514874 g/mol |
| Monoisotopic Mass | 72.057514874 g/mol |
| Topological Polar Surface Area | 17.1 Ų |
| Heavy Atom Count | 5 |
| Formal Charge | 0 |
| Complexity | 38.9 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
The pharmacokinetics of MEK in 70 male and female volunteers following a 4-hr inhalation exposure either alone (200 ppm) or in combination with acetone (225 ppm, 1:1.25 ratio) /was described./ Blood and expired air elimination data for the MEK-exposed individuals revealed on average that MEK steady-state breath levels of about 10 to 12 ppm were attained, non-steady-state peak blood levels of 3 to 4 ug/ml occurred, no significant difference in uptake or elimination was observed for males and females, and no appreciable interaction affecting elimination took place with the combined exposures.
Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V6: 149
Measurable (2.54 to 13 ug/L) quantities of methyl ethyl ketone appeared in expired air of adult humans 3 min following dermal exposure to 100 mL methyl ethyl ketone applied to 91.5 sq cm of skin.
PMID:5842337 Wurster; J Pharm Sci 54: 554 (1965)
Ketones are readily absorbed through the intact skin. Usually they are rapidly excreted ... in the expired air. /Ketones/
International Labour Office. Encyclopedia of Occupational Health and Safety. Vols. I&II. Geneva, Switzerland: International Labour Office, 1983., p. 1170
Workers occupationally exposed to methyl ethyl ketone (MEK) were examined. ... Workers exposed to 300 micrograms per liter MEK, the aveolar concn was 30% of the environmental concn. Lung uptake averaged 1.05 mg/min. The blood concn of MEK ranged from 842 to 9573 ug/L, with a mean of 2630 ug/L. Blood concn of MEK were strongly correlated with alveolar concn. MEK was more soluble in heart and muscle tissue than in lung tissue or fat. Urinary MEK excretion ranged from 120 to 1120 mg/L, with a mean of 487 mg/L. ... MEK was not persistent in the tissues. ... Urinary excretion of MEK and acetylmethylcarbinol are only around 0.1% of MEK lung absorption, the main pathway through which MEK is eliminated is unknown.
Perbellini L et al; Intern Arch Occup Environ Health 54 (1): 73-81 (1984)
For more Absorption, Distribution and Excretion (Complete) data for METHYL ETHYL KETONE (22 total), please visit the HSDB record page.
Methyl ethyl ketone (MEK) occurs ... in normal human urine and ... has possible dietary origin; its more probable precursor is alpha-methylacetoacetic acid. Like other ketones ... MEK is reduced ... in the body. Only 30-40% ... is eliminated in expired air ... .
Browning, E. Toxicity and Metabolism of Industrial Solvents. New York: American Elsevier, 1965., p. 422
Guinea pigs were given single 450 mg/kg ip doses of methyl ethyl ketone (MEK). MEK produced 2-butanol, 3-hydroxy-2-butanone, and 2,3-butanediol.
PMID:941151 DiVincenzo GD et al; Toxicol Appl Pharmacol 36 (3): 511 (1976)
Milk cultures of five Leuconostoc dextranicum strains were capable of reducing methyl ethyl ketone (MEK) to 2-butyl alcohol.
PMID:5726160 Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC547789 Keenan TW; Appl Microbiol 16: 1881-5 (1968)
Resting cells of Lactobacillus brevis 24 reduced methyl ethyl ketone (MEK) quantitatively to 2-butyl alcohol when incubated in phosphate buffer for 24 hr at 30 C.
Keen AR et al; J Dairy Res 41: 249-57 (1974)
For more Metabolism/Metabolites (Complete) data for METHYL ETHYL KETONE (11 total), please visit the HSDB record page.
Blood: 49-96 minutes; urine: 4 hours; [TDR, p. 1700]
TDR - Ryan RP, Terry CE, Leffingwell SS (eds). Toxicology Desk Reference: The Toxic Exposure and Medical Monitoring Index, 5th Ed. Washington DC: Taylor & Francis, 1999., p. 1700
MEK is rapidly cleared from the blood with a reported plasma half-life in humans of 49-96 minutes, exhibiting a biphasic elimination: t(1/2) alpha = 30 minutes and t(1/2) beta = 81 Minutes.
U.S. Environmental Protection Agency's Toxicological Review of Methyl Ethyl Ketone (CAS No. 78-93-3) In Support of Summary Information on the Integrated Risk Information system (IRIS). Available from the Database Query page at: https://www.epa.gov/iris/subst/index.html on the Substance File List as of October 10, 2007
Guinea pigs were given a single dose of methyl ethyl ketone (MEK) ip at 450 mg/kg. Blood samples were taken via cardiac puncture at 1, 2, 4, 6, 8, 12 and 16 hr after dosing. Serum half-life of MEK was estimated at 270 minutes.
Divincenzo GD et al; Toxicol Appl Pharm 36: 511-22 (1976)
... The biological half lives for elimination of acetone and MEK calculated on the basis of a first order kinetic assumption were 3.9 hours and 49 minutes, respectively. ... Workers exposed to acetone or MEK for 6 to 8 hours could expect to have a residual body burden of acetone the next morning, whereas MEK would be essentially eliminated.
Brown WD et al; The Changing Nature of Work and Workforce, Proceedings of the Third Joint US-Finish Science Symposium p.111-14 (1986)
The distribution of MEK in human tissues was examined ... in two solvent-exposed workers who died suddenly of heart attacks at the workplace. ... Distribution volumes were 6.0 for vessel-rich tissues, 39.6 for muscle and 12.8 for fat. Biological half-lives for the same tissues were 0.8, 21.8 and 23.3 min, respectively.
WHO; Environ Health Criteria 143: Methyl Ethyl Ketone p.51 (1993)
For more Biological Half-Life (Complete) data for METHYL ETHYL KETONE (8 total), please visit the HSDB record page.
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