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    6018-19-5

    ACTIVE PHARMA INGREDIENTS

    MARKET PLACE

    PharmaCompass
    $ API Ref.Price (USD/KG) : 49Xls

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    2D Structure
    Also known as: 6018-19-5, Parasal sodium, Sodium 4-amino-2-hydroxybenzoate dihydrate, Sodium aminosalicylate, Pamisyl sodium, Aminosalicylate sodium
    Molecular Formula
    C7H10NNaO5
    Molecular Weight
    211.15  g/mol
    InChI Key
    GMUQJDAYXZXBOT-UHFFFAOYSA-M
    FDA UNII
    S38B9W6AXW
    An antitubercular agent often administered in association with ISONIAZID. The sodium salt of the drug is better tolerated than the free acid.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    sodium;4-amino-2-hydroxybenzoate;dihydrate
    2.1.2 InChI
    InChI=1S/C7H7NO3.Na.2H2O/c8-4-1-2-5(7(10)11)6(9)3-4;;;/h1-3,9H,8H2,(H,10,11);;2*1H2/q;+1;;/p-1
    2.1.3 InChI Key
    GMUQJDAYXZXBOT-UHFFFAOYSA-M
    2.1.4 Canonical SMILES
    C1=CC(=C(C=C1N)O)C(=O)[O-].O.O.[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    S38B9W6AXW
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 4 Aminosalicylic Acid

    2. 4-aminosalicylic Acid

    3. Acid, Aminosalicylic

    4. Alumino 4 Aminosalicylic Acid

    5. Alumino-4-aminosalicylic Acid

    6. Aminosalicylic Acid

    7. P Aminosalicylic Acid

    8. P Aminosalicylic Acid Monolithium Salt

    9. P Aminosalicylic Acid Monopotassium Salt

    10. P Aminosalicylic Acid Monosodium Salt

    11. P-aminosalicylic Acid

    12. P-aminosalicylic Acid Monolithium Salt

    13. P-aminosalicylic Acid Monopotassium Salt

    14. P-aminosalicylic Acid Monosodium Salt

    15. P-aminosalicylic Acid, Aluminum (2:1) Salt

    16. P-aminosalicylic Acid, Calcium (2:1) Salt

    17. P-aminosalicylic Acid, Monosodium Salt, Dihydrate

    18. Pamisyl

    19. Para Aminosalicylic Acid

    20. Para-aminosalicylic Acid

    21. Rezipas

    2.3.2 Depositor-Supplied Synonyms

    1. 6018-19-5

    2. Parasal Sodium

    3. Sodium 4-amino-2-hydroxybenzoate Dihydrate

    4. Sodium Aminosalicylate

    5. Pamisyl Sodium

    6. Aminosalicylate Sodium

    7. Teebacin

    8. 4-aminosalicylic Acid Sodium Salt Dihydrate

    9. Benzoic Acid, 4-amino-2-hydroxy-, Monosodium Salt, Dihydrate

    10. Aminacyl

    11. Nemasol Sodium

    12. Paramisan Sodium

    13. Sodium 4-aminosalicylate (dihydrate)

    14. Sodium Aminosalicylate Dihydrate

    15. 4-amino-salicylic Acid Sodium Salt

    16. Para-aminosodium Salicylate

    17. Monosodium 4-aminosalicylate Dihydrate

    18. S38b9w6axw

    19. Aminosalicylate Sodium [usp]

    20. P-aminosalicylic Acid Sodium Salt Dihydrate

    21. Nsc-755862

    22. Sodium;4-amino-2-hydroxybenzoate;dihydrate

    23. 4-aminosalicylic Acid (sodium Salt Dihydrate)

    24. Aminosalicylate Sodium (usp)

    25. Sodium P.a.s.

    26. P.a.s. Sodium

    27. Unii-s38b9w6axw

    28. Mfcd00151044

    29. Parasal Sodium (tn)

    30. Aminosalyle Sodium

    31. Aminosalicylate Sodium Dihydrate

    32. Natrium-p-aminosalicylatdihydrat

    33. Sodium4-aminosalicylatedihydrate

    34. Chembl2096646

    35. Dtxsid5036638

    36. Hy-i0447a

    37. Sodium P Aminosalicylate Dihydrate

    38. Sodium P-aminosalicylate Dihydrate

    39. Cs-m3079

    40. Aminosalicylate Sodium [vandf]

    41. P-aminosalicylic Acid Monosodium Salt

    42. Akos024258376

    43. Nsc 755862

    44. As-11771

    45. Para-aminosodium Salicylate [vandf]

    46. Aminosalicylate Sodium [orange Book]

    47. P-aminosalicylate Acid Sodium Salt Dihydrate

    48. Aminosalicylate Sodium [usp Impurity]

    49. Ft-0617611

    50. Sodium 4-azanyl-2-oxidanyl-benzoate Dihydrate

    51. D00875

    52. D78312

    53. Sodium Aminosalicylate Dihydrate [vandf]

    54. Beta-d-ribopyranose1,2,3,4-tetraacetate

    55. Sodium Aminosalicylate Dihydrate [mart.]

    56. Sodium Aminosalicylate Dihydrate [who-dd]

    57. A832630

    58. Neopasalate Component Aminosalicylate Sodium

    59. Sodium 4-aminosalicylate Dihydrate, >=97.0% (t)

    60. Aminosalicylate Sodium Component Of Neopasalate

    61. Q27288525

    62. Sodium Aminosalicylate Dihydrate [ep Monograph]

    63. F1905-7110

    64. P-aminosalicylic Acid Sodium Salt Dihydrate [mi]

    65. Sodium Aminosalicylate Dihydrate For Equipment Qualification

    66. Benzoic Acid, 4-amino-2-hydroxy-, Sodium Salt, Hydrate (1:1:2)

    67. Sodium Aminosalicylate Dihydrate, European Pharmacopoeia (ep) Reference Standard

    68. Sodium Aminosalicylate Dihydrate For Equipment Qualification, European Pharmacopoeia (ep) Reference Standard

    69. Sodium Aminosalicylate Dihydrate, Pharmaceutical Secondary Standard; Certified Reference Material

    2.4 Create Date
    2007-07-12
    3 Chemical and Physical Properties
    Molecular Weight 211.15 g/mol
    Molecular Formula C7H10NNaO5
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count1
    Exact Mass211.04566670 g/mol
    Monoisotopic Mass211.04566670 g/mol
    Topological Polar Surface Area88.4 Ų
    Heavy Atom Count14
    Formal Charge0
    Complexity165
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count4
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antitubercular Agents

    Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy. (See all compounds classified as Antitubercular Agents.)

    4.2 ATC Code

    J - Antiinfectives for systemic use

    J04 - Antimycobacterials

    J04A - Drugs for treatment of tuberculosis

    J04AA - Aminosalicylic acid and derivatives

    J04AA02 - Sodium aminosalicylate