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    Acepromazine

    ACTIVE PHARMA INGREDIENTS

    INTERMEDIATES

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    2D Structure
    Also known as: 3598-37-6, Anatran, Sedalin, Soprontin, Acetopromazine maleate salt, Acepromazine monomaleate
    Molecular Formula
    C23H26N2O5S
    Molecular Weight
    442.5  g/mol
    InChI Key
    FQRHOOHLUYHMGG-BTJKTKAUSA-N
    FDA UNII
    37862HP2OM
    A phenothiazine that is used in the treatment of PSYCHOSES.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (Z)-but-2-enedioic acid;1-[10-[3-(dimethylamino)propyl]phenothiazin-2-yl]ethanone
    2.1.2 InChI
    InChI=1S/C19H22N2OS.C4H4O4/c1-14(22)15-9-10-19-17(13-15)21(12-6-11-20(2)3)16-7-4-5-8-18(16)23-19;5-3(6)1-2-4(7)8/h4-5,7-10,13H,6,11-12H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
    2.1.3 InChI Key
    FQRHOOHLUYHMGG-BTJKTKAUSA-N
    2.1.4 Canonical SMILES
    CC(=O)C1=CC2=C(C=C1)SC3=CC=CC=C3N2CCCN(C)C.C(=CC(=O)O)C(=O)O
    2.1.5 Isomeric SMILES
    CC(=O)C1=CC2=C(C=C1)SC3=CC=CC=C3N2CCCN(C)C.C(=C\C(=O)O)\C(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    37862HP2OM
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Acepromazine

    2. Acetazine

    3. Acetopromazine

    4. Acetylpromazine

    5. Calmivet

    6. Maleate, Acepromazine

    7. Plegicil

    8. Vetranquil

    2.3.2 Depositor-Supplied Synonyms

    1. 3598-37-6

    2. Anatran

    3. Sedalin

    4. Soprontin

    5. Acetopromazine Maleate Salt

    6. Acepromazine Monomaleate

    7. Acetopromazine Maleate

    8. 37862hp2om

    9. Acepromazine Hydrogen Maleate

    10. Nsc-264522

    11. Acetylpromazine Maleate (1:1)

    12. 2-acetyl-10-(3-(dimethylamino)propyl)phenothiazine, Maleate

    13. Acepromazine D6 Maleate

    14. 10-(3-(dimethylamino)propyl)phenothiazin-2-yl Methyl Ketone Maleate (1:1)

    15. Dsstox_cid_27763

    16. Dsstox_rid_82540

    17. Ethanone, 1-(10-(3-(dimethylamino)propyl)-10h-phenothiazin-2-yl)-, (z)-2-butenedioate (1:1)

    18. Dsstox_gsid_47783

    19. A 23051

    20. Notensil Maleate

    21. Maleate Acide De L'acetyl 3-dimethylamino 3-propyl-10-phenothiazine

    22. Sr-05000001648

    23. Ncgc00016634-01

    24. Cas-3598-37-6

    25. Nsc 264522

    26. Acepromazine Maleate [usan]

    27. Unii-37862hp2om

    28. Acepromazine Maleate [usan:usp]

    29. Prestwick_888

    30. Einecs 222-748-9

    31. Mfcd00082473

    32. 1-(10-(3-(dimethylamino)propyl)-10h-phenothiazin-2-yl)ethanone Maleate

    33. (z)-but-2-enedioic Acid;1-[10-[3-(dimethylamino)propyl]phenothiazin-2-yl]ethanone

    34. Acepromazinemaleate

    35. Acepromazine Hydrogenmaleate

    36. Acepromazine Maleate (usp)

    37. Schembl204733

    38. Chembl1883146

    39. Dtxsid6047783

    40. Acepromazine Maleate [mi]

    41. 2-acetyl-10-(3-dimethylaminopropyl)phenothiazine Maleate Salt

    42. Hms1569d14

    43. Hms2093n15

    44. Hms2096d14

    45. Hms3263n18

    46. Hms3713d14

    47. Pharmakon1600-01505498

    48. Phenothiazine, 2-acetyl-10-(3-(dimethylamino)propyl)-, Maleate

    49. Tox21_110536

    50. Tox21_501268

    51. Acepromazine Maleate [mart.]

    52. Nsc760058

    53. Acepromazine Maleate [usp-rs]

    54. Acepromazine Maleate [who-dd]

    55. Akos015855868

    56. Maleate Acide De L'acetyl 3-dimethylamino 3-propyl-10-phenothiazine [french]

    57. Tox21_110536_1

    58. Acepromazine Maleate, >=98% (hplc)

    59. Ccg-213470

    60. Ds-9727

    61. Nsc-760058

    62. Acepromazine Maleate [green Book]

    63. Ncgc00016634-04

    64. Ncgc00261953-01

    65. Acepromazine Maleate [usp Monograph]

    66. Cs-0013292

    67. Acepromazine Maleate 100 Microg/ml In Ethanol

    68. D02604

    69. 9-oxo-9h-thioxanthene-3-carboxylicacid&

    70. A874474

    71. A935720

    72. Sr-05000001648-1

    73. Sr-05000001648-2

    74. Q27256656

    75. Acepromazine Maleate, United States Pharmacopeia (usp) Reference Standard

    76. Ketone, 10-(3-(dimethylamino)propyl)phenothiazin-2-yl Methyl, Maleate (1:1)

    77. (2z)-but-2-enedioic Acid; 1-{10-[3-(dimethylamino)propyl]-10h-phenothiazin-2-yl}ethan-1-one

    78. 115120-92-8

    2.4 Create Date
    2006-04-14
    3 Chemical and Physical Properties
    Molecular Weight 442.5 g/mol
    Molecular Formula C23H26N2O5S
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count7
    Exact Mass442.15624311 g/mol
    Monoisotopic Mass442.15624311 g/mol
    Topological Polar Surface Area123 Ų
    Heavy Atom Count31
    Formal Charge0
    Complexity533
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count1
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antipsychotic Agents

    Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)

    Dopamine Antagonists

    Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)