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    Aclidinium Bromide

    ACTIVE PHARMA INGREDIENTS

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    2D Structure
    Also known as: 320345-99-1, Genuair, Tudorza pressair, Aclidinium (bromide), Las 34273, Las-w-330
    Molecular Formula
    C26H30BrNO4S2
    Molecular Weight
    564.6  g/mol
    InChI Key
    XLAKJQPTOJHYDR-QTQXQZBYSA-M
    FDA UNII
    UQW7UF9N91
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [(3R)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octan-3-yl] 2-hydroxy-2,2-dithiophen-2-ylacetate;bromide
    2.1.2 InChI
    InChI=1S/C26H30NO4S2.BrH/c28-25(26(29,23-9-4-17-32-23)24-10-5-18-33-24)31-22-19-27(14-11-20(22)12-15-27)13-6-16-30-21-7-2-1-3-8-21;/h1-5,7-10,17-18,20,22,29H,6,11-16,19H2;1H/q+1;/p-1/t20?,22-,27?;/m0./s1
    2.1.3 InChI Key
    XLAKJQPTOJHYDR-QTQXQZBYSA-M
    2.1.4 Canonical SMILES
    C1C[N+]2(CCC1C(C2)OC(=O)C(C3=CC=CS3)(C4=CC=CS4)O)CCCOC5=CC=CC=C5.[Br-]
    2.1.5 Isomeric SMILES
    C1C[N+]2(CCC1[C@H](C2)OC(=O)C(C3=CC=CS3)(C4=CC=CS4)O)CCCOC5=CC=CC=C5.[Br-]
    2.2 Other Identifiers
    2.2.1 UNII
    UQW7UF9N91
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. (3r)-3-((hydroxy(di-2-thienyl)acetyl)oxy)-1-(3-phenoxypropyl)-1-azoniabicyclo(2.2.2)octane Bromide

    2.3.2 Depositor-Supplied Synonyms

    1. 320345-99-1

    2. Genuair

    3. Tudorza Pressair

    4. Aclidinium (bromide)

    5. Las 34273

    6. Las-w-330

    7. Las-34273

    8. Las W-330

    9. Las-34273 Micronized

    10. Uqw7uf9n91

    11. Chebi:65344

    12. (3r)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane Bromide

    13. (3r)-3-(2-hydroxy-2,2-di(thiophen-2-yl)acetoxy)-1-(3-phenoxypropyl)quinuclidin-1-ium Bromide

    14. (r)-3-(2-hydroxy-2,2-di(thiophen-2-yl)acetoxy)-1-(3-phenoxypropyl)quinuclidin-1-ium Bromide

    15. Bretaris

    16. Eklira

    17. Chembl551466

    18. (3r)-3-((hydroxydi(thiophen-2-yl)acetyl)oxy)-1-(3-phenoxypropyl)-1-azoniabicyclo(2.2.2)octane Bromide

    19. [(8r)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octan-8-yl] 2-hydroxy-2,2-dithiophen-2-ylacetate Bromide

    20. 1-azoniabicyclo(2.2.2)octane, 3-((hydroxydi-2-thienylacetyl)oxy)-1-(3-phenoxypropyl)-, Bromide, (3r)-

    21. Unii-uqw7uf9n91

    22. Aclidinium Bromide [usan]

    23. Aclidinium Bromide [usan:inn]

    24. Eklira Genuair (tn)

    25. Tudorza Pressair (tn)

    26. (3r)-3-{[hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane Bromide

    27. Schembl72694

    28. Krp-ab1102

    29. Aclidinium Bromide [mi]

    30. Aclidinium Bromide [inn]

    31. Aclidinium Bromide [jan]

    32. Las 34273 Micronized

    33. Las-w 330

    34. Dtxsid30185854

    35. Aclidinium Bromide [vandf]

    36. Hms3885c20

    37. Aclidinium Bromide [mart.]

    38. Aclidinium Bromide [who-dd]

    39. Aclidinium Bromide (jan/usan/inn)

    40. Mfcd09954105

    41. S4031

    42. Akos016010522

    43. Ccg-270072

    44. Cs-0896

    45. Aclidinium Bromide [orange Book]

    46. Ac-23963

    47. Bs-16987

    48. Hy-14144

    49. Sw219176-1

    50. D08837

    51. D81774

    52. Duaklir Pressair Component Aclidinium Bromide

    53. J-018606

    54. Q27888207

    55. Aclidinium Bromide Component Of Duaklir Pressair

    56. (3r)-3-((2-hydroxy-2,2-di-2-thienylacetyl)oxy)-1-(3-phenoxypropyl)-1-azoniabicyclo(2.2.2)octane Bromide (1:1)

    57. (3r)-3-[2-hydroxy(di-2-thienyl)acetoxy]-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane Bromide

    58. [(3r)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octan-3-yl] 2-hydroxy-2,2-dithiophen-2-ylacetate;bromide

    59. 1-azoniabicyclo(2.2.2)octane, 3-((2-hydroxy-2,2-di-2-thienylacetyl)oxy)-1-(3-phenoxypropyl)-, Bromide (1:1), (3r)-

    60. 3(r)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane Bromide

    2.4 Create Date
    2006-10-26
    3 Chemical and Physical Properties
    Molecular Weight 564.6 g/mol
    Molecular Formula C26H30BrNO4S2
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count10
    Exact Mass563.07996 g/mol
    Monoisotopic Mass563.07996 g/mol
    Topological Polar Surface Area112 Ų
    Heavy Atom Count34
    Formal Charge0
    Complexity647
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameTudorza pressair
    PubMed HealthAclidinium (By breathing)
    Drug ClassesBronchodilator, Respiratory Agent
    Drug LabelTUDORZA PRESSAIR consists of a dry powder formulation of aclidinium bromide for oral inhalation only.Aclidinium bromide, the active component of TUDORZA PRESSAIR is an anticholinergic with specificity for muscarinic receptors. Aclidinium bromide is a...
    Active IngredientAclidinium bromide
    Dosage FormPowder, metered
    RouteInhalation
    Strength0.375mg/inh
    Market StatusPrescription
    CompanyForest Labs

    2 of 2  
    Drug NameTudorza pressair
    PubMed HealthAclidinium (By breathing)
    Drug ClassesBronchodilator, Respiratory Agent
    Drug LabelTUDORZA PRESSAIR consists of a dry powder formulation of aclidinium bromide for oral inhalation only.Aclidinium bromide, the active component of TUDORZA PRESSAIR is an anticholinergic with specificity for muscarinic receptors. Aclidinium bromide is a...
    Active IngredientAclidinium bromide
    Dosage FormPowder, metered
    RouteInhalation
    Strength0.375mg/inh
    Market StatusPrescription
    CompanyForest Labs

    4.2 Drug Indication

    Eklira Genuair is indicated as a maintenance bronchodilator treatment to relieve symptoms in adult patients with chronic obstructive pulmonary disease (COPD).

    Bretaris Genuair is indicated as a maintenance bronchodilator treatment to relieve symptoms in adult patients with chronic obstructive pulmonary disease (COPD).

    5 Pharmacology and Biochemistry
    5.1 FDA Pharmacological Classification
    5.1.1 Pharmacological Classes
    Cholinergic Antagonists [MoA]; Anticholinergic [EPC]
    5.2 ATC Code

    R03BB

    R03BB

    R03AL05

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

    R - Respiratory system

    R03 - Drugs for obstructive airway diseases

    R03B - Other drugs for obstructive airway diseases, inhalants

    R03BB - Anticholinergics

    R03BB05 - Aclidinium bromide