Please Wait
Applying Filters...
Menu
Xls
2D Structure
Also known as: 1256589-74-8, Af-802 hydrochloride, Alectinib hcl, Alecensa, P9yy73lo6j, Alectinib hydrochloride (jan)
Molecular Formula
C30H35ClN4O2
Molecular Weight
519.1  g/mol
InChI Key
GYABBVHSRIHYJR-UHFFFAOYSA-N
FDA UNII
P9YY73LO6J

1 2D Structure

2D Structure

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
9-ethyl-6,6-dimethyl-8-(4-morpholin-4-ylpiperidin-1-yl)-11-oxo-5H-benzo[b]carbazole-3-carbonitrile;hydrochloride
2.1.2 InChI
InChI=1S/C30H34N4O2.ClH/c1-4-20-16-23-24(17-26(20)34-9-7-21(8-10-34)33-11-13-36-14-12-33)30(2,3)29-27(28(23)35)22-6-5-19(18-31)15-25(22)32-29;/h5-6,15-17,21,32H,4,7-14H2,1-3H3;1H
2.1.3 InChI Key
GYABBVHSRIHYJR-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCC1=CC2=C(C=C1N3CCC(CC3)N4CCOCC4)C(C5=C(C2=O)C6=C(N5)C=C(C=C6)C#N)(C)C.Cl
2.2 Other Identifiers
2.2.1 UNII
P9YY73LO6J
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Alecensa

2. Alectinib

3. Ch5424802

4. Ro5424802

2.3.2 Depositor-Supplied Synonyms

1. 1256589-74-8

2. Af-802 Hydrochloride

3. Alectinib Hcl

4. Alecensa

5. P9yy73lo6j

6. Alectinib Hydrochloride (jan)

7. Alectinib (hydrochloride)

8. Ch5424802 (hydrochloride)

9. Schembl14991271

10. 5h-benzo[b]carbazole-3-carbonitrile, 9-ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-, Hydrochloride (1:1)

11. Alectinib Hydrochloride [jan]

12. 9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-6,11-dihydro-5h-benzo[b]carbazole-3-carbonitrile Hydrochloride

13. Unii-p9yy73lo6j

14. Alecensa (tn)

15. 5h-benzo(b)carbazole-3-carbonitrile, 9-ethyl-6,11-dihydro-6,6-dimethyl-8-(4-(4-morpholinyl)-1-piperidinyl)-11-oxo-, Hydrochloride (1:1)

16. Alectinib Monohydrochloride

17. Af-802 (hydrochloride)

18. Agn-pc-09o9bf

19. Ro5424802 (hydrochloride)

20. Chembl3707320

21. Chebi:62268

22. Ch5424802 Hcl

23. Dtxsid10154841

24. Ch 5424802, Alectinib Hcl

25. Bcp09075

26. Ex-a1553

27. Alectinib Hydrochloride [mi]

28. Ch-5424802 Hydrochloride

29. Hy-13011a

30. Mfcd27987893

31. S5232

32. Ccg-264759

33. Cs-3480

34. Sb16516

35. Alectinib Hydrochloride [who-dd]

36. 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-ylpiperidin-1-yl)-11-oxo-5h-benzo[b]carbazole-3-carbonitrile,hydrochloride

37. Ac-29721

38. As-17062

39. Alectinib Hydrochloride [orange Book]

40. D10450

41. Q27104897

42. Ch5424802 Hcl Salt, Alectinib Hcl Salt, Af802 Hcl Salt

43. Ch-5428402 Hcl; Af-802 Hydrochloride; Rg-7853 Hydrochloride; Ro-5424802 Hydrochloride

44. 9-ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5h-benzo[b]carbazole-3-carbonitrile Hydrochloride (1:1)

45. 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-11-oxo-6,11-dihydro-5h-benzo[b]carbazole-3-carbonitrile Monohydrochloride Salt

46. 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-ylpiperidin-1-yl)-11-oxo-5h-benzo[b]carbazole-3-carbonitrile;hydrochloride

47. Alectinib Hydrochloride;af-802 Hydrochloride;ch-5424802 Hydrochloride;rg-7853 Hydrochloride;ro-5424802 Hydrochloride

2.3.3 Other Synonyms

1. Alectinib

2. 1256580-46-7

3. Arq-761

4. Cas 1416163-60-4

5. Cas 1256580-46-7

2.4 Create Date
2011-07-05
3 Chemical and Physical Properties
Molecular Weight 519.1 g/mol
Molecular Formula C30H35ClN4O2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass518.2448541 g/mol
Monoisotopic Mass518.2448541 g/mol
Topological Polar Surface Area72.4 Ų
Heavy Atom Count37
Formal Charge0
Complexity867
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Indication

Alecensa as monotherapy is indicated for the first-line treatment of adult patients with anaplastic lymphoma kinase (ALK)-positive advanced non-small cell lung cancer (NSCLC).

Alecensa as monotherapy is indicated for the treatment of adult patients with ALKpositive advanced NSCLC previously treated with crizotinib.


5 Pharmacology and Biochemistry
5.1 FDA Pharmacological Classification
5.1.1 Pharmacological Classes
Kinase Inhibitors [MoA]; Kinase Inhibitor [EPC]
5.2 ATC Code

L01ED03