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    Allopurinol Sodium

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    DIGITAL CONTENT

    PharmaCompass
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    2D Structure
    Also known as: 17795-21-0, Sodium 1h-pyrazolo[3,4-d]pyrimidin-4-olate, Sodium allopurinol, Allopurinol sodium salt, Aloprim, Sodium;1h-pyrazolo[3,4-d]pyrimidin-4-olate
    Molecular Formula
    C5H3N4NaO
    Molecular Weight
    158.09  g/mol
    InChI Key
    PTJRZVJXXNYNLN-UHFFFAOYSA-M
    Allopurinol Sodium is the sodium form of allopurinol, which is a structural isomer of hypoxanthine. Allopurinol inhibits xanthine oxidase, an enzyme that converts oxypurines to uric acid. By blocking the production of uric acid, this agent decreases serum and urine concentrations of uric acid, thereby providing protection against uric acid-mediated end organ damage in conditions associated with excessive production of uric acid, i.e. the massive cell lysis associated with the treatment of some malignancies. (NCI04)
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    sodium;1H-pyrazolo[3,4-d]pyrimidin-4-olate
    2.1.2 InChI
    InChI=1S/C5H4N4O.Na/c10-5-3-1-8-9-4(3)6-2-7-5;/h1-2H,(H2,6,7,8,9,10);/q;+1/p-1
    2.1.3 InChI Key
    PTJRZVJXXNYNLN-UHFFFAOYSA-M
    2.1.4 Canonical SMILES
    C1=NNC2=C1C(=NC=N2)[O-].[Na+]
    2.2 Synonyms
    2.2.1 Depositor-Supplied Synonyms

    1. 17795-21-0

    2. Sodium 1h-pyrazolo[3,4-d]pyrimidin-4-olate

    3. Sodium Allopurinol

    4. Allopurinol Sodium Salt

    5. Aloprim

    6. Sodium;1h-pyrazolo[3,4-d]pyrimidin-4-olate

    7. Allopurinol Sodium (aloprim)

    8. 1,5-dihydro-4h-pyrazolo(3,4-d)pyrimidin-4-one, Monosodium Salt

    9. 428673rc2z

    10. Einecs 241-771-5

    11. Nsc 108836

    12. Unii-428673rc2z

    13. 1h-pyrazolo(3,4-d)pyrimidin-4-ol, Monosodium Salt

    14. 4h-pyrazolo(3,4-d)pyrimidin-4-one, 1,5-dihydro-, Monosodium Salt

    15. Allopurinolsodium

    16. Schembl17223898

    17. 1,5-dihydro-4h-pyrazolo[3,4-d]pyrimidin-4-one,monosodiumsalt

    18. Akos015899245

    19. Ac-4257

    20. Sodium 1h-pyrazolo[3,4-d]pyrimidine-4-olate

    21. F76872

    22. A881435

    23. Q27258510

    2.3 Create Date
    2008-02-05
    3 Chemical and Physical Properties
    Molecular Weight 158.09 g/mol
    Molecular Formula C5H3N4NaO
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count0
    Exact Mass158.02045501 g/mol
    Monoisotopic Mass158.02045501 g/mol
    Topological Polar Surface Area77.5 Ų
    Heavy Atom Count11
    Formal Charge0
    Complexity136
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameAllopurinol sodium
    PubMed HealthAllopurinol (Injection)
    Drug ClassesAntigout, Urinary Stone Agent
    Active IngredientAllopurinol sodium
    Dosage FormInjectable
    RouteInjection
    Strengtheq 500mg base/vial
    Market StatusPrescription
    CompanyEurohlth Intl

    2 of 4  
    Drug NameAloprim
    Active IngredientAllopurinol sodium
    Dosage FormInjectable
    RouteInjection
    Strengtheq 500mg base/vial
    Market StatusPrescription
    CompanyMylan Institutional

    3 of 4  
    Drug NameAllopurinol sodium
    PubMed HealthAllopurinol (Injection)
    Drug ClassesAntigout, Urinary Stone Agent
    Active IngredientAllopurinol sodium
    Dosage FormInjectable
    RouteInjection
    Strengtheq 500mg base/vial
    Market StatusPrescription
    CompanyEurohlth Intl

    4 of 4  
    Drug NameAloprim
    Active IngredientAllopurinol sodium
    Dosage FormInjectable
    RouteInjection
    Strengtheq 500mg base/vial
    Market StatusPrescription
    CompanyMylan Institutional

    5 Pharmacology and Biochemistry
    5.1 FDA Pharmacological Classification
    5.1.1 Pharmacological Classes
    Xanthine Oxidase Inhibitors [MoA]; Xanthine Oxidase Inhibitor [EPC]