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2D Structure
Also known as: Dried aluminum hydroxide gel, Aluminum;trihydroxide, Aluminium hydroxide gel, dried, Dried aluminium hydroxide, Aluminum hydroxide, dried, Aluminium hydroxide, dried
Molecular Formula
AlH3O3
Molecular Weight
78.004  g/mol
InChI Key
WNROFYMDJYEPJX-UHFFFAOYSA-K
FDA UNII
5QB0T2IUN0

Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects.
1 2D Structure

2D Structure

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
aluminum;trihydroxide
2.1.2 InChI
InChI=1S/Al.3H2O/h;3*1H2/q+3;;;/p-3
2.1.3 InChI Key
WNROFYMDJYEPJX-UHFFFAOYSA-K
2.1.4 Canonical SMILES
[OH-].[OH-].[OH-].[Al+3]
2.2 Other Identifiers
2.2.1 UNII
5QB0T2IUN0
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Dried Aluminum Hydroxide Gel

2. Aluminum;trihydroxide

3. Aluminium Hydroxide Gel, Dried

4. Dried Aluminium Hydroxide

5. Aluminum Hydroxide, Dried

6. Aluminium Hydroxide, Dried

7. Aluminum Hydroxide Gel, Dried

8. Nsc-664400

9. Aluminum Hydrate

10. Aluminum Hyroxide

11. Aluminium Trihydroxide

12. Hydroxyde D' Aluminium

13. Algeldrate Anhydrous

14. Aluminum (as Hydroxide)

15. Aluminum Hydroxide [ii]

16. Aluminum Hydroxide [mi]

17. Chembl1200706

18. Dtxsid2036405

19. Niosh/bd0708000

20. Aluminum Hydroxide [inci]

21. Di-mu-hydroxytetrahydroxydialuminum

22. Aluminum Hydroxide [vandf]

23. Aluminium Hydroxide[who-ip]

24. Aluminum Hydroxide [mart.]

25. Aluminum Hydroxide Gel,dried

26. Aluminium Hydroxide Dried Gel

27. Af-260

28. Aluminium Hydroxide [who-dd]

29. Akos015904617

30. Aluminum, Di-mu-hydroxytetrahydroxydi-

31. Db06723

32. Aluminum Hydroxide [orange Book]

33. Aluminii Hydroxidum[who-ip Latin]

34. Aluminum (as Hydroxide) [vandf]

35. Aluminum Hydroxide [usp Impurity]

36. Aluminum Hydroxide, Dried [hsdb]

37. As04 Component Aluminum Hydroxide

38. Aluminum Hydroxide Gel, Dried [ii]

39. Foamcoat Component Aluminum Hydroxide

40. Foamicon Component Aluminum Hydroxide

41. Gaviscon Component Aluminum Hydroxide

42. Aluminum Hydroxide Gel,dried [vandf]

43. Bd07080000

44. Dried Aluminum Hydroxide Gel [usp-rs]

45. Aluminum Hydroxide Component Of Foamcoat

46. Aluminum Hydroxide Component Of Foamicon

47. Aluminum Hydroxide Component Of Gaviscon

48. Aluminium Hydroxide Gel, Dried [who-dd]

49. Aluminum Hydroxide, Dried [usp Impurity]

50. Q407125

51. J-014205

52. 8012-63-3

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 78.004 g/mol
Molecular Formula AlH3O3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count0
Exact Mass77.9897574 g/mol
Monoisotopic Mass77.9897574 g/mol
Topological Polar Surface Area3 Ų
Heavy Atom Count4
Formal Charge0
Complexity0
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count4
4 Drug and Medication Information
4.1 Drug Indication

For relief of heartburn and acid indigestion.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Gastric-peptic disease occurs as a result of an imbalance between protective factors, such as mucus, bicarbonate, and prostaglandin secretion, and aggressive factors, such as hydrochloric acid, pepsin, and Helicobacter pylori (H. pylori). Antacids work by restoring acid-base balance, attenuating the pepsin activity and increasing bicarbonate and prostaglandin secretion.


5.2 Absorption, Distribution and Excretion

Absorption

Approximately 17-30% of the aluminum chloride formed is absorbed.


Route of Elimination

Absorbed aluminum chloride is rapidly eliminated by the kidneys in patients with normal renal function.


5.3 Metabolism/Metabolites

Not metabolized.


5.4 Mechanism of Action

Aluminum hydroxide is a basic inorganic salt that acts by neutralizing hydrochloric acid in gastric secretions. Aluminum hydroxide is slowly solubilized in the stomach and reacts with hydrochloric acid to form aluminum chloride and water. It also inhibits the action of pepsin by increasing the pH and via adsorption. Cytoprotective effects may occur through increases in bicarbonate ion (HCO3-) and prostaglandins.