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    Aluminium Hydroxide

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    2D Structure
    Also known as: Dried aluminum hydroxide gel, Aluminum;trihydroxide, Aluminium hydroxide gel, dried, Dried aluminium hydroxide, Aluminum hydroxide, dried, Aluminium hydroxide, dried
    Molecular Formula
    AlH3O3
    Molecular Weight
    78.004  g/mol
    InChI Key
    WNROFYMDJYEPJX-UHFFFAOYSA-K
    FDA UNII
    5QB0T2IUN0
    Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    aluminum;trihydroxide
    2.1.2 InChI
    InChI=1S/Al.3H2O/h;3*1H2/q+3;;;/p-3
    2.1.3 InChI Key
    WNROFYMDJYEPJX-UHFFFAOYSA-K
    2.1.4 Canonical SMILES
    [OH-].[OH-].[OH-].[Al+3]
    2.2 Other Identifiers
    2.2.1 UNII
    5QB0T2IUN0
    2.3 Synonyms
    2.3.1 Depositor-Supplied Synonyms

    1. Dried Aluminum Hydroxide Gel

    2. Aluminum;trihydroxide

    3. Aluminium Hydroxide Gel, Dried

    4. Dried Aluminium Hydroxide

    5. Aluminum Hydroxide, Dried

    6. Aluminium Hydroxide, Dried

    7. Aluminum Hydroxide Gel, Dried

    8. Nsc-664400

    9. Aluminum Hydrate

    10. Aluminum Hyroxide

    11. Aluminium Trihydroxide

    12. Hydroxyde D' Aluminium

    13. Algeldrate Anhydrous

    14. Aluminum (as Hydroxide)

    15. Aluminum Hydroxide [ii]

    16. Aluminum Hydroxide [mi]

    17. Chembl1200706

    18. Dtxsid2036405

    19. Niosh/bd0708000

    20. Aluminum Hydroxide [inci]

    21. Di-mu-hydroxytetrahydroxydialuminum

    22. Aluminum Hydroxide [vandf]

    23. Aluminium Hydroxide[who-ip]

    24. Aluminum Hydroxide [mart.]

    25. Aluminum Hydroxide Gel,dried

    26. Aluminium Hydroxide Dried Gel

    27. Af-260

    28. Aluminium Hydroxide [who-dd]

    29. Akos015904617

    30. Aluminum, Di-mu-hydroxytetrahydroxydi-

    31. Db06723

    32. Aluminum Hydroxide [orange Book]

    33. Aluminii Hydroxidum[who-ip Latin]

    34. Aluminum (as Hydroxide) [vandf]

    35. Aluminum Hydroxide [usp Impurity]

    36. Aluminum Hydroxide, Dried [hsdb]

    37. As04 Component Aluminum Hydroxide

    38. Aluminum Hydroxide Gel, Dried [ii]

    39. Foamcoat Component Aluminum Hydroxide

    40. Foamicon Component Aluminum Hydroxide

    41. Gaviscon Component Aluminum Hydroxide

    42. Aluminum Hydroxide Gel,dried [vandf]

    43. Bd07080000

    44. Dried Aluminum Hydroxide Gel [usp-rs]

    45. Aluminum Hydroxide Component Of Foamcoat

    46. Aluminum Hydroxide Component Of Foamicon

    47. Aluminum Hydroxide Component Of Gaviscon

    48. Aluminium Hydroxide Gel, Dried [who-dd]

    49. Aluminum Hydroxide, Dried [usp Impurity]

    50. Q407125

    51. J-014205

    52. 8012-63-3

    2.4 Create Date
    2006-10-25
    3 Chemical and Physical Properties
    Molecular Weight 78.004 g/mol
    Molecular Formula AlH3O3
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count0
    Exact Mass77.9897574 g/mol
    Monoisotopic Mass77.9897574 g/mol
    Topological Polar Surface Area3 Ų
    Heavy Atom Count4
    Formal Charge0
    Complexity0
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count4
    4 Drug and Medication Information
    4.1 Drug Indication

    For relief of heartburn and acid indigestion.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Gastric-peptic disease occurs as a result of an imbalance between protective factors, such as mucus, bicarbonate, and prostaglandin secretion, and aggressive factors, such as hydrochloric acid, pepsin, and Helicobacter pylori (H. pylori). Antacids work by restoring acid-base balance, attenuating the pepsin activity and increasing bicarbonate and prostaglandin secretion.

    5.2 Absorption, Distribution and Excretion

    Absorption

    Approximately 17-30% of the aluminum chloride formed is absorbed.

    Route of Elimination

    Absorbed aluminum chloride is rapidly eliminated by the kidneys in patients with normal renal function.

    5.3 Metabolism/Metabolites

    Not metabolized.

    5.4 Mechanism of Action

    Aluminum hydroxide is a basic inorganic salt that acts by neutralizing hydrochloric acid in gastric secretions. Aluminum hydroxide is slowly solubilized in the stomach and reacts with hydrochloric acid to form aluminum chloride and water. It also inhibits the action of pepsin by increasing the pH and via adsorption. Cytoprotective effects may occur through increases in bicarbonate ion (HCO3-) and prostaglandins.