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    Technical details about Amantadine Sulphate, learn more about the structure, uses, toxicity, action, side effects and more

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    Amantadine Sulphate

    APIs // Active Pharmaceutical Ingredients

    DOSSIERs // Finished Dosage Forms

    DIGITAL CONTENT

    PharmaCompass

    Farmhispania Group, a leading European CDMO in HPAPI Technologies & High Potency Fermentation.

    One Pharma aims to be one of the leading generic companies in Europe.

    2D Structure
    1. Also known as: 31377-23-8, Amantadine sulphate, Amantadine (sulfate), 31377-23-8 (sulfate), Tricyclo[3.3.1.13,7]decan-1-amine, sulfate (2:1), Tricyclo(3.3.1.1(3,7))decan-1-amine, sulfate (2:1)
    Molecular Formula
    C20H36N2O4S
    Molecular Weight
    400.6  g/mol
    InChI Key
    MYWTWSQFJLXGGQ-UHFFFAOYSA-N
    FDA UNII
    9921T5P019
    An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    adamantan-1-amine;sulfuric acid
    2.1.2 InChI
    InChI=1S/2C10H17N.H2O4S/c2*11-10-4-7-1-8(5-10)3-9(2-7)6-10;1-5(2,3)4/h2*7-9H,1-6,11H2;(H2,1,2,3,4)
    2.1.3 InChI Key
    MYWTWSQFJLXGGQ-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1C2CC3CC1CC(C2)(C3)N.C1C2CC3CC1CC(C2)(C3)N.OS(=O)(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    9921T5P019
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 1 Aminoadamantane

    2. 1-aminoadamantane

    3. Adamantylamine

    4. Adekin

    5. Al, Amantadin

    6. Aman

    7. Amanta

    8. Amanta Hci Azu

    9. Amanta Sulfate Azu

    10. Amanta-hci-azu

    11. Amanta-sulfate-azu

    12. Amantadin Al

    13. Amantadin Azu

    14. Amantadin Neuraxpharm

    15. Amantadin Ratiopharm

    16. Amantadin Stada

    17. Amantadin-neuraxpharm

    18. Amantadin-ratiopharm

    19. Amantadina Juventus

    20. Amantadina Llorente

    21. Amantadine

    22. Amantadine Hydrochloride

    23. Amantadinneuraxpharm

    24. Amantadinratiopharm

    25. Amantahciazu

    26. Amantasulfateazu

    27. Amixx

    28. Azu, Amantadin

    29. Cerebramed

    30. Endantadine

    31. Gen Amantadine

    32. Gen-amantadine

    33. Genamantadine

    34. Hydrochloride, Amantadine

    35. Infecto Flu

    36. Infecto-flu

    37. Infectoflu

    38. Infex

    39. Juventus, Amantadina

    40. Llorente, Amantadina

    41. Mantadix

    42. Midantan

    43. Pms Amantadine

    44. Pms-amantadine

    45. Pmsamantadine

    46. Stada, Amantadin

    47. Sulfate, Amantadine

    48. Symadine

    49. Symmetrel

    50. Tregor

    51. Viregyt

    52. Wiregyt

    2.3.2 Depositor-Supplied Synonyms

    1. 31377-23-8

    2. Amantadine Sulphate

    3. Amantadine (sulfate)

    4. 31377-23-8 (sulfate)

    5. Tricyclo[3.3.1.13,7]decan-1-amine, Sulfate (2:1)

    6. Tricyclo(3.3.1.1(3,7))decan-1-amine, Sulfate (2:1)

    7. 9921t5p019

    8. 1-adamantanamine Sulphate

    9. 1-aminoadamantane Sulphate

    10. Amantadine Sulphate [inn]

    11. Amantadine Hemisulfate

    12. Schembl5919747

    13. Amantadine Sulfate [mi]

    14. Chebi:78351

    15. Dtxsid50953416

    16. Unii-9921t5p019

    17. Amantadine Sulfate (2:1)

    18. Amantadine Sulfate [mart.]

    19. Amantadine Sulfate [who-dd]

    20. Amantadine Sulphate (2:1)

    21. Einecs 250-604-5

    22. Mfcd00077251

    23. Ls-14828

    24. Sulfuric Acid--adamantan-1-amine (1/2)

    25. 1-adamantanamine Sulfate Salt (2:1)

    26. 1-adamantanamine Sulphate Salt (2:1)

    27. D88414

    28. Q27147778

    29. Tricyclo(3.3.1.19(sup 3,7))decan-1-amine

    2.3.3 Other Synonyms

    1. Aliud Brand Of Amantadine Sulfate

    2. Amanta Sulfate Azu

    3. Amantasulfateazu

    4. Amanta-sulfate-azu

    5. Azupharma Brand Of Amantadine Sulfate

    6. Hexal Brand Of Amantadine Sulfate

    7. Hormosan Brand Of Amantadine Sulfate

    8. Merz Brand Of Amantadine Sulfate

    9. Neuraxpharm Brand Of Amantadine Sulfate

    10. Neuro Hexal Brand Of Amantadine Sulfate

    11. Stada Brand Of Amantadine Sulfate

    12. Sulfate, Amantadine

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 400.6 g/mol
    Molecular Formula C20H36N2O4S
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count0
    Exact Mass400.23957881 g/mol
    Monoisotopic Mass400.23957881 g/mol
    Topological Polar Surface Area135 Ų
    Heavy Atom Count27
    Formal Charge0
    Complexity225
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antiparkinson Agents

    Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists. (See all compounds classified as Antiparkinson Agents.)

    Analgesics, Non-Narcotic

    A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS. (See all compounds classified as Analgesics, Non-Narcotic.)

    Antiviral Agents

    Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)

    Dopamine Agents

    Any drugs that are used for their effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons. (See all compounds classified as Dopamine Agents.)

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