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    Technical details about Amdizalisib, learn more about the structure, uses, toxicity, action, side effects and more

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    Amdizalisib

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    Biophore is a research-driven global pharmaceutical company focused on niche APIs for the generic industry.

    Athena Pharmaceutiques is a Partner of Choice for Drug Delivery & Life Cycle Management.

    2D Structure
    1. Also known as: Amdizalisib [inn], F3ymy7783p, 1894229-03-8, 4-amino-6-[[(1s)-1-(3-chloro-6-phenylimidazo[1,2-b]pyridazin-7-yl)ethyl]amino]pyrimidine-5-carbonitrile, 4-amino-6-{[(1s)-1-(3-chloro-6-phenylimidazo[1,2-b]pyridazin-7-yl)ethyl]amino}pyrimidine-5-carbonitrile, 5-pyrimidinecarbonitrile, 4-amino-6-(((1s)-1-(3-chloro-6-phenylimidazo(1,2-b)pyridazin-7-yl)ethyl)amino)-
    Molecular Formula
    C19H15ClN8
    Molecular Weight
    390.8  g/mol
    InChI Key
    WKDBRCUUDXLTIM-NSHDSACASA-N
    FDA UNII
    F3YMY7783P
    Amdizalisib is an orally bioavailable selective inhibitor of the delta isoform of phosphatidylinositide 3-kinase (phosphoinositide 3'-kinase delta; PI3Kd; PI3K-d), with potential antineoplastic activity. Upon oral administration, amdizalisib selectively binds to and inhibits PI3Kd, and prevents the activation of the PI3Kd/AKT signaling pathway, and B-cell activation. This both decreases proliferation and induces cell death in PI3Kd-overexpressing tumor cells. PI3Kd plays a key role in the B-cell receptor (BCR) signaling pathway and the proliferation of hematologic cancer cells. The targeted inhibition of PI3Kd is designed to preserve PI3K signaling in normal, non-neoplastic cells and thereby to minimize serious side effects. PI3Kd, an enzyme often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    4-amino-6-[[(1S)-1-(3-chloro-6-phenylimidazo[1,2-b]pyridazin-7-yl)ethyl]amino]pyrimidine-5-carbonitrile
    2.1.2 InChI
    InChI=1S/C19H15ClN8/c1-11(26-19-14(8-21)18(22)24-10-25-19)13-7-16-23-9-15(20)28(16)27-17(13)12-5-3-2-4-6-12/h2-7,9-11H,1H3,(H3,22,24,25,26)/t11-/m0/s1
    2.1.3 InChI Key
    WKDBRCUUDXLTIM-NSHDSACASA-N
    2.1.4 Canonical SMILES
    CC(C1=CC2=NC=C(N2N=C1C3=CC=CC=C3)Cl)NC4=NC=NC(=C4C#N)N
    2.1.5 Isomeric SMILES
    C[C@@H](C1=CC2=NC=C(N2N=C1C3=CC=CC=C3)Cl)NC4=NC=NC(=C4C#N)N
    2.2 Other Identifiers
    2.2.1 UNII
    F3YMY7783P
    2.3 Synonyms
    2.3.1 Depositor-Supplied Synonyms

    1. Amdizalisib [inn]

    2. F3ymy7783p

    3. 1894229-03-8

    4. 4-amino-6-[[(1s)-1-(3-chloro-6-phenylimidazo[1,2-b]pyridazin-7-yl)ethyl]amino]pyrimidine-5-carbonitrile

    5. 4-amino-6-{[(1s)-1-(3-chloro-6-phenylimidazo[1,2-b]pyridazin-7-yl)ethyl]amino}pyrimidine-5-carbonitrile

    6. 5-pyrimidinecarbonitrile, 4-amino-6-(((1s)-1-(3-chloro-6-phenylimidazo(1,2-b)pyridazin-7-yl)ethyl)amino)-

    7. 5-pyrimidinecarbonitrile, 4-amino-6-[[(1s)-1-(3-chloro-6-phenylimidazo[1,2-b]pyridazin-7-yl)ethyl]amino]-

    8. Amdizalisib [who-dd]

    9. Amdizalisib [usan]

    10. Unii-f3ymy7783p

    11. Hmpl-689

    12. Chembl4438249

    13. Schembl17633481

    14. Gtpl11699

    15. Us10208066, Compound 4

    16. Bdbm350391

    17. Zinc584641354

    18. Compound 4 [wo2016045591a1]

    19. Compound 28 [pmid: 30582813]

    20. Hy-132807

    21. Cs-0204054

    22. (s)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyridazin-7-yl)ethyl)amino)pyrimidine-5-carbonitrile

    23. 4-amino-6-(((1s)-1-(3-chloro-6-phenylimidazo(1,2-b)pyridazin-7-yl)ethyl)amino)-5-pyrimidinecarbonitrile

    2.4 Create Date
    2016-04-09
    3 Chemical and Physical Properties
    Molecular Weight 390.8 g/mol
    Molecular Formula C19H15ClN8
    XLogP33.4
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count4
    Exact Mass g/mol
    Monoisotopic Mass g/mol
    Topological Polar Surface Area118
    Heavy Atom Count28
    Formal Charge0
    Complexity576
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
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