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    Amiprilose

    ACTIVE PHARMA INGREDIENTS

    PharmaCompass
    Xls

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    2D Structure
    Also known as: Dsstox_cid_25883, Dsstox_rid_81198, Dsstox_gsid_45883, 1-[(3ar,5r,6s,6ar)-6-[3-(dimethylamino)propoxy]-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]ethane-1,2-diol;hydrochloride, Sr-01000075667, Ncgc00095000-01
    Molecular Formula
    C14H28ClNO6
    Molecular Weight
    341.83  g/mol
    InChI Key
    RJNRORZRFGUAKL-VPHFYIDPSA-N
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-[(3aR,5R,6S,6aR)-6-[3-(dimethylamino)propoxy]-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]ethane-1,2-diol;hydrochloride
    2.1.2 InChI
    InChI=1S/C14H27NO6.ClH/c1-14(2)20-12-11(18-7-5-6-15(3)4)10(9(17)8-16)19-13(12)21-14;/h9-13,16-17H,5-8H2,1-4H3;1H/t9?,10-,11+,12-,13-;/m1./s1
    2.1.3 InChI Key
    RJNRORZRFGUAKL-VPHFYIDPSA-N
    2.1.4 Canonical SMILES
    CC1(OC2C(C(OC2O1)C(CO)O)OCCCN(C)C)C.Cl
    2.1.5 Isomeric SMILES
    CC1(O[C@@H]2[C@H]([C@H](O[C@@H]2O1)C(CO)O)OCCCN(C)C)C.Cl
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. 1,2-o-isopropylidene-3-o-3'-(n',n'-dimethylamino-n-propyl)-d-glucofuranose

    2. 3-o-(3-(dimethylamino)propyl)-1,2-o-(1-methylethylidene)- Alpha-d-glucofuranose

    3. Amiprilose

    4. Amprilose

    5. Sm 1213

    6. Sm-1213

    7. Therafectin

    2.2.2 Depositor-Supplied Synonyms

    1. Dsstox_cid_25883

    2. Dsstox_rid_81198

    3. Dsstox_gsid_45883

    4. 1-[(3ar,5r,6s,6ar)-6-[3-(dimethylamino)propoxy]-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]ethane-1,2-diol;hydrochloride

    5. Sr-01000075667

    6. Ncgc00095000-01

    7. Cas-60414-06-4

    8. Schembl41474

    9. Chembl3184686

    10. Dtxsid5045883

    11. Tox21_111382

    12. Tox21_111382_1

    13. Lp00047

    14. Ncgc00162052-05

    15. Eu-0100047

    16. A 4687

    17. Sr-01000075667-1

    18. Sr-01000075667-5

    19. 1,2-o-isopropylidene-3-o-[3'-(n,n-dimethylamino)propyl]-alpha-d-glucofuranose Hydrochloride

    2.3 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 341.83 g/mol
    Molecular Formula C14H28ClNO6
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count7
    Exact Mass341.1605153 g/mol
    Monoisotopic Mass341.1605153 g/mol
    Topological Polar Surface Area80.6 Ų
    Heavy Atom Count22
    Formal Charge0
    Complexity337
    Isotope Atom Count0
    Defined Atom Stereocenter Count4
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-Inflammatory Agents, Non-Steroidal

    Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

    Adjuvants, Immunologic

    Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. (See all compounds classified as Adjuvants, Immunologic.)

    Antiviral Agents

    Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)