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    Amlodipine Maleate

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    DIGITAL CONTENT

    GLOBAL SALES INFORMATION

    MARKET PLACE

    REF. STANDARDS & IMPURITIES

    PharmaCompass
    $ API Ref.Price (USD/KG) : 437Xls

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    2D Structure
    Also known as: 88150-47-4, Amvaz, Amlodipine (maleate), Amlodipine maleate [usan], Cq27g2bzjm, 1357024-06-6
    Molecular Formula
    C24H29ClN2O9
    Molecular Weight
    524.9  g/mol
    InChI Key
    TZNOWAJJWCGILX-BTJKTKAUSA-N
    FDA UNII
    CQ27G2BZJM
    A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (Z)-but-2-enedioic acid;3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
    2.1.2 InChI
    InChI=1S/C20H25ClN2O5.C4H4O4/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;5-3(6)1-2-4(7)8/h5-8,17,23H,4,9-11,22H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
    2.1.3 InChI Key
    TZNOWAJJWCGILX-BTJKTKAUSA-N
    2.1.4 Canonical SMILES
    CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C(=CC(=O)O)C(=O)O
    2.1.5 Isomeric SMILES
    CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C(=C\C(=O)O)\C(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    CQ27G2BZJM
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Amlodipine

    2. Amlodipine Besylate

    3. Amlodipine Maleate (1:1)

    4. Amlodipine, (+-)-isomer

    5. Amlodipine, (+-)-isomer, Maleate (1:1)

    6. Amlodipine, (r)-isomer

    7. Amlodipine, (s)-isomer, Maleate (1:1)

    8. Amlodis

    9. Amlor

    10. Astudal

    11. Istin

    12. Norvasc

    2.3.2 Depositor-Supplied Synonyms

    1. 88150-47-4

    2. Amvaz

    3. Amlodipine (maleate)

    4. Amlodipine Maleate [usan]

    5. Cq27g2bzjm

    6. 1357024-06-6

    7. Uk-48,340-11

    8. Amlodipine (+-)-form Maleate

    9. (z)-but-2-enedioic Acid;3-o-ethyl 5-o-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

    10. 3-ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate Maleate

    11. Uk-48340-11

    12. Amlodipine Maleate (usan)

    13. Unii-cq27g2bzjm

    14. Uk 48,340-11

    15. Amvaz (tn)

    16. 3-ethyl 5-methyl (+-)-2-((2-aminoethoxy)methyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate, Maleate (1:1)

    17. Schembl121252

    18. Amlodipine Maleate [mi]

    19. Chembl1200984

    20. Hy-b0317a

    21. Dtxsid601027708

    22. Amlodipine Maleate [mart.]

    23. Amlodipine Maleate [who-dd]

    24. Bcp12616

    25. Mfcd02259457

    26. S5966

    27. Akos015962119

    28. Ac-4701

    29. Cs-3987

    30. Amlodipine Maleate [orange Book]

    31. 3,5-pyridinedicarboxylic Acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl Ester, (+-)-, (z)-2-butenedioate (1:1)

    32. As-14630

    33. Ba164165

    34. D02914

    35. 150a474

    36. Q27275625

    37. 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine Maleate

    38. 3,5-pyridinedicarboxylic Acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl Ester, (+/-)-, (z)-2-butenedioate (1:1)

    39. 3,5-pyridinedicarboxylic Acid,2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-,3-ethyl 5-methyl Ester, (2z)-2-butenedioate (1:1)

    40. 3-ethyl 5-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate Maleate (1:1)

    41. 3-ethyl5-methyl2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylatemaleate

    2.4 Create Date
    2006-04-28
    3 Chemical and Physical Properties
    Molecular Weight 524.9 g/mol
    Molecular Formula C24H29ClN2O9
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count11
    Rotatable Bond Count12
    Exact Mass524.1561582 g/mol
    Monoisotopic Mass524.1561582 g/mol
    Topological Polar Surface Area175 Ų
    Heavy Atom Count36
    Formal Charge0
    Complexity766
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count1
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

    Calcium Channel Blockers

    A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)

    Vasodilator Agents

    Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)