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    Ammonium Acetate

    ACTIVE PHARMA INGREDIENTS

    MARKET PLACE

    PharmaCompass
    $ API Ref.Price (USD/KG) : 1,574Xls

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    2D Structure
    Also known as: 631-61-8, Acetic acid, ammonium salt, Ammoniumacetate, Azanium;acetate, Acetic acid ammonium salt, Ammonium ethanoate
    Molecular Formula
    C2H7NO2
    Molecular Weight
    77.08  g/mol
    InChI Key
    USFZMSVCRYTOJT-UHFFFAOYSA-N
    FDA UNII
    RRE756S6Q2
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    azanium;acetate
    2.1.2 InChI
    InChI=1S/C2H4O2.H3N/c1-2(3)4;/h1H3,(H,3,4);1H3
    2.1.3 InChI Key
    USFZMSVCRYTOJT-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC(=O)[O-].[NH4+]
    2.2 Other Identifiers
    2.2.1 UNII
    RRE756S6Q2
    2.3 Synonyms
    2.3.1 Depositor-Supplied Synonyms

    1. 631-61-8

    2. Acetic Acid, Ammonium Salt

    3. Ammoniumacetate

    4. Azanium;acetate

    5. Acetic Acid Ammonium Salt

    6. Ammonium Ethanoate

    7. Aconh4

    8. Ch3coonh4

    9. Ch3co2nh4

    10. Rre756s6q2

    11. Ammonia Acetate

    12. Mfcd00013066

    13. Azanium Acetate

    14. Amoniumacetate

    15. Unii-rre756s6q2

    16. Ammonium-acetate

    17. Hsdb 556

    18. Acetic Acid Amine

    19. Ammonium Acetate-

    20. Ammonia Acetate Salt

    21. Einecs 211-162-9

    22. Acetic Acid Ammoniate

    23. Ammonium Acetate Acs

    24. Nh4oac

    25. Ammonium Aceticum

    26. Ai3-26540

    27. Ec 211-162-9

    28. Ammonium Acetate [ii]

    29. Ammonium Acetate [mi]

    30. Ammonium Acetate Solution, 5m

    31. Ins No. 264

    32. Ammonium Acetate [hsdb]

    33. Ammonium Acetate [inci]

    34. Ammonium Aceticum [hpus]

    35. Dtxsid5023873

    36. Chebi:62947

    37. Ammonium Acetate [mart.]

    38. Ammonium Acetate [who-dd]

    39. Ammonium Acetate, Biochemical Grade

    40. Acetic Acid, Ammonium Salt (1:1)

    41. Akos015904610

    42. Ammonium Acetate, 5m Aqueous Solution

    43. E264

    44. E 264

    45. E-264

    46. Ft-0622306

    2.4 Create Date
    2005-03-27
    3 Chemical and Physical Properties
    Molecular Weight 77.08 g/mol
    Molecular Formula C2H7NO2
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count0
    Exact Mass77.047678466 g/mol
    Monoisotopic Mass77.047678466 g/mol
    Topological Polar Surface Area41.1 Ų
    Heavy Atom Count5
    Formal Charge0
    Complexity25.5
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    Diuretic

    Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989., p. 82

    MEDICATION (VET): AS NUTRIENT

    Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 15

    MEDICATION (VET): Formerly a diuretic, antipyretic

    Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989., p. 82

    5 Pharmacology and Biochemistry
    5.1 Mechanism of Action

    ALTHOUGH PRECISE MECHANISM OF SYSTEMIC AMMONIA INTOXICATION REMAINS TO BE ELUCIDATED, EVIDENCE EXISTS TO SUGGEST THAT AN INTERFERENCE WITH CEREBRAL OXIDATIVE ENERGY METABOLISM IS INVOLVED. IN RATS MADE COMATOSE WITH AMMONIUM ACETATE, SAMPLES OF BASILAR BRAIN STRUCTURES SHOWED SIGNIFICANT DECR IN GLYCOGEN, GLUCOSE, ATP, & ESPECIALLY IN PHOSPHOCREATINE.

    Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. III-23

    The effects of ammonium ions on the release of glutamic acid from the rat cerebral cortex were measured in vivo using cortical cups & multiple ion detection technique. The results indicate that ammonium ions increase the release & the formation of glutamic acid in the brain. The resulting increased concn of this amino acid in extracellular spaces may be one of the mechanisms of ammonia toxicity in vivo. /Ammonium ions/

    PMID:6131108 Moroni F et al; J Neurochem 40 (3): 850-4 (1983)