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2D Structure
Also known as: 515-98-0, Lac-hydrin, Ammonium (+-)-lactate, Ammonium lactate [usan], Azanium;2-hydroxypropanoate, Propanoic acid, 2-hydroxy-, monoammonium salt
Molecular Formula
C3H9NO3
Molecular Weight
107.11  g/mol
InChI Key
RZOBLYBZQXQGFY-UHFFFAOYSA-N
FDA UNII
67M901L9NQ

A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
Ammonium lactate is an alpha-Hydroxy Acid.
1 2D Structure

2D Structure

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
azanium;2-hydroxypropanoate
2.1.2 InChI
InChI=1S/C3H6O3.H3N/c1-2(4)3(5)6;/h2,4H,1H3,(H,5,6);1H3
2.1.3 InChI Key
RZOBLYBZQXQGFY-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(C(=O)[O-])O.[NH4+]
2.2 Other Identifiers
2.2.1 UNII
67M901L9NQ
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2 Hydroxypropanoic Acid

2. 2 Hydroxypropionic Acid

3. 2-hydroxypropanoic Acid

4. 2-hydroxypropionic Acid

5. D Lactic Acid

6. D-lactic Acid

7. L Lactic Acid

8. L-lactic Acid

9. Lactate

10. Lactate, Ammonium

11. Lactic Acid

12. Propanoic Acid, 2-hydroxy-, (2r)-

13. Propanoic Acid, 2-hydroxy-, (2s)-

14. Sarcolactic Acid

2.3.2 Depositor-Supplied Synonyms

1. 515-98-0

2. Lac-hydrin

3. Ammonium (+-)-lactate

4. Ammonium Lactate [usan]

5. Azanium;2-hydroxypropanoate

6. Propanoic Acid, 2-hydroxy-, Monoammonium Salt

7. Lactate (monoammonium)

8. Lactic Acid Ammonium Salt

9. 2-hydroxypropanoic Acid Monoammonium Salt

10. 67m901l9nq

11. Lac Hydrin

12. Bms-186091

13. Lachydrin

14. Ammonium Lactate (usan)

15. Propanoic Acid, 2-hydroxy-, Ammonium Salt (1:1)

16. Amlactin

17. Laclotion

18. (+/-)-ammonium Lactate; Bms 186091; Lac-hydrin; W 1001-10

19. Kerasal Al

20. Ammonium 2-hydroxypropanoate

21. Einecs 208-214-8

22. 52003-58-4

23. Bms 186091

24. Unii-67m901l9nq

25. Lac-hydrin (tn)

26. Ammonium2-hydroxypropanoate

27. Schembl36407

28. Ammonium Lactate [mi]

29. Ammonium Lactate [inci]

30. Ammonium Lactate [vandf]

31. Ammonium-l-2-hydroxy-propionate

32. Dtxsid3052808

33. Propanoic Acid, 2-hydroxy-, Monoammonium Salt, (+-)-

34. Ammonium (+/-)-lactate

35. Ammonium Lactate [mart.]

36. Lactic Acid Ammonium Salt (inn)

37. Ammonium Lactate [who-dd]

38. Hms3264p05

39. Ammonium Lactate [orange Book]

40. Ccg-213638

41. Db06768

42. Nsc 760427

43. Db-071380

44. D02920

45. 515-98-052003-58-4(replacedby515-98-0)

46. Propanoic Acid, 2-hydroxy-, Monoammonium Salt, (+/-)-

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 107.11 g/mol
Molecular Formula C3H9NO3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count0
Exact Mass107.058243149 g/mol
Monoisotopic Mass107.058243149 g/mol
Topological Polar Surface Area61.4 Ų
Heavy Atom Count7
Formal Charge0
Complexity53.5
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 4  
Drug NameAmmonium lactate
PubMed HealthAmmonium Lactate (On the skin)
Drug ClassesAntipruritic
Drug LabelAmmonium Lactate Cream, 12% is a formulation of 12% lactic acid neutralized with ammonium hydroxide, as ammonium lactate with a pH of 4.4-5.4.Ingredients: Ammonium Lactate Cream, 12% also contains cetyl alcohol, glycerin, glyceryl stearate, light min...
Active IngredientAmmonium lactate
Dosage FormLotion; Cream
RouteTopical
Strengtheq 12% base
Market StatusPrescription
CompanyWatson Labs; Perrigo New York; Taro

2 of 4  
Drug NameLac-hydrin
PubMed HealthAmmonium Lactate (On the skin)
Drug ClassesAntipruritic
Drug Label*Lac-Hydrin is a formulation of 12% lactic acid neutralized with ammonium hydroxide, as ammonium lactate with a pH of 4.4-5.4. Lac-Hydrin 12% (ammonium lactate) Cream also contains cetyl alcohol, glycerin, glyceryl stearate, laureth-4, light minera...
Active IngredientAmmonium lactate
Dosage FormCream; Lotion
RouteTopical
Strengtheq 12% base
Market StatusPrescription
CompanyRanbaxy

3 of 4  
Drug NameAmmonium lactate
PubMed HealthAmmonium Lactate (On the skin)
Drug ClassesAntipruritic
Drug LabelAmmonium Lactate Cream, 12% is a formulation of 12% lactic acid neutralized with ammonium hydroxide, as ammonium lactate with a pH of 4.4-5.4.Ingredients: Ammonium Lactate Cream, 12% also contains cetyl alcohol, glycerin, glyceryl stearate, light min...
Active IngredientAmmonium lactate
Dosage FormLotion; Cream
RouteTopical
Strengtheq 12% base
Market StatusPrescription
CompanyWatson Labs; Perrigo New York; Taro

4 of 4  
Drug NameLac-hydrin
PubMed HealthAmmonium Lactate (On the skin)
Drug ClassesAntipruritic
Drug Label*Lac-Hydrin is a formulation of 12% lactic acid neutralized with ammonium hydroxide, as ammonium lactate with a pH of 4.4-5.4. Lac-Hydrin 12% (ammonium lactate) Cream also contains cetyl alcohol, glycerin, glyceryl stearate, laureth-4, light minera...
Active IngredientAmmonium lactate
Dosage FormCream; Lotion
RouteTopical
Strengtheq 12% base
Market StatusPrescription
CompanyRanbaxy

4.2 Drug Indication

For the treatment of dry, scaly skin (xerosis) and ichthyosis vulgaris and for temporary relief of itching associated with these conditions.


FDA Label


5 Pharmacology and Biochemistry
5.1 Pharmacology

Lactic acid is an alpha-hydroxy acid. It is a normal constituent of tissues and blood. The alpha-hydroxy acids (and their salts) may act as humectants when applied to the skin. This property may influence hydration of the stratum corneum. In addition, lactic acid, when applied to the skin, may act to decrease corneocyte cohesion.


5.2 FDA Pharmacological Classification
5.2.1 Active Moiety
AMMONIUM LACTATE
5.2.2 FDA UNII
67M901L9NQ
5.2.3 Pharmacological Classes
Acidifying Activity [MoA]
5.3 Absorption, Distribution and Excretion

Absorption

In vitro study of percutaneous absorption of ammonium lactate lotion, 12% using human cadaver skin indicates that approximately 5.8% of the material was absorbed after 68 hours.


5.4 Mechanism of Action

Unknown.