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    Amorolfine Hydrochloride

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    GLOBAL SALES INFORMATION

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    REF. STANDARDS & IMPURITIES

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    2D Structure
    Also known as: Amorolfine hcl, 78613-38-4, Amorolfin, Loceryl, 106614-68-0, Amorolfine (hydrochloride)
    Molecular Formula
    C21H36ClNO
    Molecular Weight
    354.0  g/mol
    InChI Key
    XZKWIPVTHGWDCF-KUZYQSSXSA-N
    FDA UNII
    741YH7379H
    Amorolfine Hydrochloride is the hyrochloride salt form of amorolfine, a morpholine antifungal agent. Amorolfine inhibits delta-14-reductase and delta-7,8-isomerase, which depletes ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membrane.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (2R,6S)-2,6-dimethyl-4-[2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl]morpholine;hydrochloride
    2.1.2 InChI
    InChI=1S/C21H35NO.ClH/c1-7-21(5,6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22;/h8-11,16-18H,7,12-15H2,1-6H3;1H/t16?,17-,18+;
    2.1.3 InChI Key
    XZKWIPVTHGWDCF-KUZYQSSXSA-N
    2.1.4 Canonical SMILES
    CCC(C)(C)C1=CC=C(C=C1)CC(C)CN2CC(OC(C2)C)C.Cl
    2.1.5 Isomeric SMILES
    CCC(C)(C)C1=CC=C(C=C1)CC(C)CN2C[C@H](O[C@H](C2)C)C.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    741YH7379H
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Amorolfin Hydrochloride

    2. Amorolfine

    3. Locryl

    4. Loceryl

    5. Locetar

    6. Odenil

    7. Ro 14-4767-002

    8. Ro-14-4767-002

    2.3.2 Depositor-Supplied Synonyms

    1. Amorolfine Hcl

    2. 78613-38-4

    3. Amorolfin

    4. Loceryl

    5. 106614-68-0

    6. Amorolfine (hydrochloride)

    7. Amorolfine Hydrochloride [jan]

    8. Amorolfine Hydrochloride

    9. 741yh7379h

    10. 78613-38-4 (hcl)

    11. (2r,6s)-2,6-dimethyl-4-(2-methyl-3-(4-(tert-pentyl)phenyl)propyl)morpholine Hydrochloride

    12. Amorolfine Hydrochloride (jan)

    13. Curanail

    14. Locetar

    15. Pekiron

    16. Odenil

    17. Amorolfine (as Hydrochloride)

    18. 2,6-dimethyl-4-(2-methyl-3-(4-(tert-pentyl)phenyl)propyl)morpholine Hydrochloride

    19. (2r,6s)-2,6-dimethyl-4-[2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl]morpholine;hydrochloride

    20. Bekiron

    21. Unii-741yh7379h

    22. (2r,6s)-rel-2,6-dimethyl-4-(2-methyl-3-(4-(tert-pentyl)phenyl)propyl)morpholine Hydrochloride

    23. Pekiron (tn)

    24. Mfcd00903738

    25. Starbld0005329

    26. Schembl36711

    27. Mls006010200

    28. Ro-14-4767/000

    29. Amorolfine Hydrochloride- Bio-x

    30. Chembl4303363

    31. Amorolfine For System Suitability

    32. Chebi:59649

    33. Dtxsid80229217

    34. Hy-b0238

    35. Ac-080

    36. Amorolfine Hydrochloride [mi]

    37. Mt-861

    38. S1676

    39. Akos015912323

    40. Ccg-213057

    41. Amorolfine Hydrochloride [mart.]

    42. Amorolfine Hydrochloride [who-dd]

    43. As-13295

    44. Ba164168

    45. Smr004701299

    46. Amorolfine Hydrochloride, >=98% (hplc)

    47. Sw219285-1

    48. Ro-14-4767/002

    49. Amorolfine Hydrochloride [ep Monograph]

    50. D01720

    51. 613a384

    52. Q27888046

    53. (2r,6s)-2,6-dimethyl-4-(2-methyl-3-(4-tert-pentylphenyl)propyl)morpholine Hydrochloride

    54. (2s,6r)-2,6-dimethyl-4-(2-methyl-3-(4-tert-pentylphenyl)propyl)morpholine Hydrochloride

    55. (2r,6s)-2,6-dimethyl-4-{2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl}morpholine Hydrochloride

    56. (2s,6r)-2,6-dimethyl-4-[2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl]morpholine;hydrochloride

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 354.0 g/mol
    Molecular Formula C21H36ClNO
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count6
    Exact Mass353.2485425 g/mol
    Monoisotopic Mass353.2485425 g/mol
    Topological Polar Surface Area12.5 Ų
    Heavy Atom Count24
    Formal Charge0
    Complexity336
    Isotope Atom Count0
    Defined Atom Stereocenter Count2
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antifungal Agents

    Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)