Please Wait
Applying Filters...
menu
    • menu
    Granules India Limited has high volume world-class facilities for APIs, PFIs, & FDFs, serving customers in over 80 countries.

    Virtual Booth

    Contact Supplier

    Jai Radhe Sales is your partner for all your sourcing needs.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2024-10-07

    Virtual Booth

    Contact Supplier

    Egis is a Hungarian generic pharma company with 110 years history. Our activities incorporate all areas of the pharma value chain.

    Virtual Booth

    Contact Supplier

    Biophore is a research-driven global pharmaceutical company focused on niche APIs for the generic industry.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2024-10-07

    Virtual Booth

    Contact Supplier

    Menu

    Ampalex

    PharmaCompass
    Xls

    Filters

    clear-filterReset all filters
    2D Structure
    Also known as: 154235-83-3, Piperidin-1-yl(quinoxalin-6-yl)methanone, Cx-516, Cx516, Bdp 12, 1-(quinoxalin-6-ylcarbonyl)piperidine
    Molecular Formula
    C14H15N3O
    Molecular Weight
    241.29  g/mol
    InChI Key
    ANDGGVOPIJEHOF-UHFFFAOYSA-N
    FDA UNII
    Z5QU38B4V9
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    piperidin-1-yl(quinoxalin-6-yl)methanone
    2.1.2 InChI
    InChI=1S/C14H15N3O/c18-14(17-8-2-1-3-9-17)11-4-5-12-13(10-11)16-7-6-15-12/h4-7,10H,1-3,8-9H2
    2.1.3 InChI Key
    ANDGGVOPIJEHOF-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1CCN(CC1)C(=O)C2=CC3=NC=CN=C3C=C2
    2.2 Other Identifiers
    2.2.1 UNII
    Z5QU38B4V9
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 1-(quinoxalin-6-ylcarbonyl)piperidine

    2. Bdp 12

    3. Bdp-12

    4. Cx516

    2.3.2 Depositor-Supplied Synonyms

    1. 154235-83-3

    2. Piperidin-1-yl(quinoxalin-6-yl)methanone

    3. Cx-516

    4. Cx516

    5. Bdp 12

    6. 1-(quinoxalin-6-ylcarbonyl)piperidine

    7. 1-(6-quinoxalinylcarbonyl)piperidine

    8. Bdp-12

    9. Cx 516

    10. Abt-224

    11. Piperidine, 1-(6-quinoxalinylcarbonyl)-

    12. 6-(piperidine-1-carbonyl)quinoxaline

    13. 1-piperidyl(quinoxalin-6-yl)methanone

    14. Chembl136800

    15. Z5qu38b4v9

    16. 173047-75-1

    17. Chebi:34605

    18. 287399-47-7

    19. 1-(quinoxalin-6-ylcarbonyl)-piperidine

    20. Piperidin-1-yl-quinoxalin-6-yl-methanone

    21. Unii-z5qu38b4v9

    22. Spd-420

    23. Ampakine Cx516

    24. 1-piperidinyl-6-quinoxalinylmethanone

    25. Ampalex-[d10]

    26. Bdp-12(ampalex)

    27. Ampalex (cx-516)

    28. Ampalex, Cx-516

    29. Schembl194605

    30. Gtpl4165

    31. Zinc6489

    32. Ampalex I(1/4)oecx-516

    33. Dtxsid70165574

    34. Ex-a265

    35. Amy14816

    36. Bcp04606

    37. Ac-001

    38. Bdbm50094009

    39. Mfcd00943201

    40. Akos008927689

    41. 1-piperidinyl-6-quinoxalinyl-methanone

    42. Bcp9000296

    43. Cs-1086

    44. Db06247

    45. Ds-1548

    46. Fs-3368

    47. 6-[(piperidin-1-yl)carbonyl]quinoxaline

    48. Ncgc00371146-01

    49. Cx516, >=98% (hplc)

    50. Hy-10933

    51. Bcp0726000046

    52. Ft-0657266

    53. Vu0430675-1

    54. 235a833

    55. J-009084

    56. Q5014875

    57. Cx5

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 241.29 g/mol
    Molecular Formula C14H15N3O
    XLogP31.8
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count1
    Exact Mass241.121512110 g/mol
    Monoisotopic Mass241.121512110 g/mol
    Topological Polar Surface Area46.1 Ų
    Heavy Atom Count18
    Formal Charge0
    Complexity301
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Investigated for use/treatment in alzheimer's disease, memory loss, autism, neurologic disorders, dementia, schizophrenia and schizoaffective disorders, attention deficit/hyperactivity disorder (ADHD), and sleep disorders.

    5 Pharmacology and Biochemistry
    5.1 Mechanism of Action

    CX 516 is a benzylpiperidine AMPAkine, an AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) modulator, that enhances the function of glutamate when it binds allosterically to the AMPA receptor channel complex. CX 516 slows receptor deactivation with a longer open time, slower excitatory postsynaptic potential (EPSP) decay and improvement of hippocampal long term potentiation (LTP).