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    Amylmetacresol

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    DIGITAL CONTENT

    MARKET PLACE

    REF. STANDARDS & IMPURITIES

    PharmaCompass
    $ API Ref.Price (USD/KG) : 492Xls

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    2D Structure
    Also known as: 5-methyl-2-pentylphenol, 1300-94-3, 5-methyl-2-n-pentylphenol, 6-pentyl-m-cresol, 6-amyl-m-cresol, 6-n-amyl-m-cresol
    Molecular Formula
    C12H18O
    Molecular Weight
    178.27  g/mol
    InChI Key
    CKGWFZQGEQJZIL-UHFFFAOYSA-N
    FDA UNII
    05W904P57F
    Amylmetacresol is an antiseptic available in Canada over-the-counter in a number of lozenges for the treatment of sore throat and minor mouth infections,. Amylmetacresol is often combined with dichlorobenzyl alcohol and menthol in the commonly used sore throat lozenges, known as Strepsils. The acute sore throat (pharyngitis) is one of the most common conditions for which children are seen in the primary care setting. Pharyngitis is normally caused by viruses and proves benign and self-limiting. Clinically proven, over-the-counter throat lozenges offer rapid and effective relief of acute sore throat symptoms, and are increasingly important in the management of this condition.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    5-methyl-2-pentylphenol
    2.1.2 InChI
    InChI=1S/C12H18O/c1-3-4-5-6-11-8-7-10(2)9-12(11)13/h7-9,13H,3-6H2,1-2H3
    2.1.3 InChI Key
    CKGWFZQGEQJZIL-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCCCCC1=C(C=C(C=C1)C)O
    2.2 Other Identifiers
    2.2.1 UNII
    05W904P57F
    2.3 Synonyms
    2.3.1 Depositor-Supplied Synonyms

    1. 5-methyl-2-pentylphenol

    2. 1300-94-3

    3. 5-methyl-2-n-pentylphenol

    4. 6-pentyl-m-cresol

    5. 6-amyl-m-cresol

    6. 6-n-amyl-m-cresol

    7. 6-n-pentyl-m-cresol

    8. Amylmetacresolum

    9. Phenol, 5-methyl-2-pentyl-

    10. Amyl Metacresol

    11. 2-amyl-5-methylphenol

    12. Chebi:48213

    13. 05w904p57f

    14. Ncgc00180998-01

    15. Amilmetacresol

    16. Amilmetacresol [spanish]

    17. Amylmetacresolum [latin]

    18. Amylmetacresol [inn:ban]

    19. Brn 2440952

    20. M-cresol, 6-pentyl-

    21. Einecs 215-094-0

    22. Unii-05w904p57f

    23. Amylmetacresol [inn]

    24. Dsstox_cid_26791

    25. Dsstox_rid_81908

    26. Dsstox_gsid_46791

    27. 3-06-00-02005 (beilstein Handbook Reference)

    28. Amylmetacresol [vandf]

    29. Schembl302197

    30. Amylmetacresol [mart.]

    31. Amyl Metacresol [vandf]

    32. Amylmetacresol [who-dd]

    33. Chembl1512677

    34. Dtxsid8046791

    35. 6-n-amyl-m-cresol [mi]

    36. Baa30094

    37. Zinc2039651

    38. Amylmetacresol [ep Impurity]

    39. Tox21_112651

    40. Amylmetacresol [ep Monograph]

    41. Mfcd00127710

    42. S6173

    43. Stl453583

    44. Akos015912095

    45. Db13908

    46. 5-methyl-2-n-pentylphenol, Aldrichcpr

    47. Ds-15450

    48. Cas-1300-94-3

    49. Hy-121527

    50. Cs-0082471

    51. Ft-0620948

    52. Amylmetacresol 100 Microg/ml In Acetonitrile

    53. A888790

    54. Sr-01000944860

    55. Q1946346

    56. Sr-01000944860-1

    57. W-108357

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 178.27 g/mol
    Molecular Formula C12H18O
    XLogP34.4
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count1
    Rotatable Bond Count4
    Exact Mass178.135765193 g/mol
    Monoisotopic Mass178.135765193 g/mol
    Topological Polar Surface Area20.2 Ų
    Heavy Atom Count13
    Formal Charge0
    Complexity133
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Sore throat, minor mouth and throat infections,,.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    The mixture of amylmetacresol throat lozenge medications markedly reduces the infectivity of certain infectious viruses in the throat and in cough droplets, thus reducing opportunities for person-to-person transmission. In addition, it relieves symptoms of sore throat/irritation of the throat,. Amylmetacresol is thought to inhibit the inflammatory and pain mediators that are involved in the inflammation of the mouth and throat mucous membranes, as well as the sore throat.

    5.2 Absorption, Distribution and Excretion

    Absorption

    Rapidly absorbed and eliminated.

    5.3 Mechanism of Action

    The mechanism of virucidal action is not fully elucidated, however it is suggested that denaturation of external protein spikes, a pH-induced rearrangement of the tertiary structure of attachment proteins, or a selective effect on viral lipid membranes/proteinlipid interaction is responsible for this action. Amylmetacresol is an antibacterial and antiviral agent, and blocks voltage-gated Na channels in a local anesthetic-like manner.