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    Technical details about Anlotinib, learn more about the structure, uses, toxicity, action, side effects and more

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    Anlotinib

    APIs // Active Pharmaceutical Ingredients

    PharmaCompass

    Farmhispania Group, a leading European CDMO in HPAPI Technologies & High Potency Fermentation.

    One Pharma aims to be one of the leading generic companies in Europe.

    2D Structure
    1. Also known as: 1058156-90-3, Catequentinib, Al3818, Al-3818, Al 3818, Gkf8s4c432
    Molecular Formula
    C23H22FN3O3
    Molecular Weight
    407.4  g/mol
    InChI Key
    KSMZEXLVHXZPEF-UHFFFAOYSA-N
    FDA UNII
    GKF8S4C432
    Anlotinib is a receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic and anti-angiogenic activities. Upon administration, anlotininib targets multiple RTKs, including vascular endothelial growth factor receptor type 2 (VEGFR2) and type 3 (VEGFR3). This agent may both inhibit angiogenesis and halt tumor cell growth.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-[[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxyquinolin-7-yl]oxymethyl]cyclopropan-1-amine
    2.1.2 InChI
    InChI=1S/C23H22FN3O3/c1-13-9-15-16(27-13)3-4-19(22(15)24)30-18-5-8-26-17-11-21(20(28-2)10-14(17)18)29-12-23(25)6-7-23/h3-5,8-11,27H,6-7,12,25H2,1-2H3
    2.1.3 InChI Key
    KSMZEXLVHXZPEF-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=CC2=C(N1)C=CC(=C2F)OC3=C4C=C(C(=CC4=NC=C3)OCC5(CC5)N)OC
    2.2 Other Identifiers
    2.2.1 UNII
    GKF8S4C432
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Al3818

    2.3.2 Depositor-Supplied Synonyms

    1. 1058156-90-3

    2. Catequentinib

    3. Al3818

    4. Al-3818

    5. Al 3818

    6. Gkf8s4c432

    7. 1-[[4-[(4-fluoro-2-methyl-1h-indol-5-yl)oxy]-6-methoxyquinolin-7-yl]oxymethyl]cyclopropan-1-amine

    8. Cyclopropanamine, 1-(((4-((4-fluoro-2-methyl-1h-indol-5-yl)oxy)-6-methoxy-7-quinolinyl)oxy)methyl)-

    9. Catequentinib [inn]

    10. Unii-gkf8s4c432

    11. Catequentinib [who-dd]

    12. Gtpl9601

    13. Schembl2063386

    14. Chembl4303201

    15. Bcp24991

    16. Ex-a2427

    17. Nsc832523

    18. Zinc117924202

    19. Cs-5396

    20. Db11885

    21. Nsc-832523

    22. Sb19798

    23. Hy-19716

    24. 4678b

    25. C13643

    26. Q27279141

    27. 1-(((4-((4-fluoro-2-methyl-1h-indol-5-yl)oxy)-6-methoxy-7-quinolinyl)oxy)methyl)cyclopropanamine

    28. 1-(((4-((4-fluoro-2-methyl-1h-indol-5-yl)oxy)-6-methoxyquinolin-7-yl)oxy)methyl)cyclopropan-1-amine

    29. 1-((4-(4-fluoro-2-methyl-1h-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)methyl)cyclopropan-amine

    2.4 Create Date
    2008-11-03
    3 Chemical and Physical Properties
    Molecular Weight 407.4 g/mol
    Molecular Formula C23H22FN3O3
    XLogP33.7
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count6
    Exact Mass407.16451973 g/mol
    Monoisotopic Mass407.16451973 g/mol
    Topological Polar Surface Area82.4 Ų
    Heavy Atom Count30
    Formal Charge0
    Complexity606
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
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