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    Antazoline HCl

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    MARKET PLACE

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    2D Structure
    Also known as: 2508-72-7, Antazoline hcl, Phenazoline hydrochloride, Antazoline (hydrochloride), 2-(n-benzylanilinomethyl)-2-imidazoline hydrochloride, N-benzyl-n-(4,5-dihydro-1h-imidazol-2-ylmethyl)aniline hydrochloride
    Molecular Formula
    C17H20ClN3
    Molecular Weight
    301.8  g/mol
    InChI Key
    SWKDMSRRIBZZAY-UHFFFAOYSA-N
    FDA UNII
    FP8Q8F72JH
    An antagonist of histamine H1 receptors.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline;hydrochloride
    2.1.2 InChI
    InChI=1S/C17H19N3.ClH/c1-3-7-15(8-4-1)13-20(14-17-18-11-12-19-17)16-9-5-2-6-10-16;/h1-10H,11-14H2,(H,18,19);1H
    2.1.3 InChI Key
    SWKDMSRRIBZZAY-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1CN=C(N1)CN(CC2=CC=CC=C2)C3=CC=CC=C3.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    FP8Q8F72JH
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Analergine

    2. Antasten

    3. Antazoline

    4. Antazoline Phosphate

    5. Antazoline Phosphate (1:1)

    6. Antistine

    7. Arithmin

    8. Hydrochloride, Antazoline

    9. Imidamine

    10. Phenazoline

    11. Phosphate, Antazoline

    2.3.2 Depositor-Supplied Synonyms

    1. 2508-72-7

    2. Antazoline Hcl

    3. Phenazoline Hydrochloride

    4. Antazoline (hydrochloride)

    5. 2-(n-benzylanilinomethyl)-2-imidazoline Hydrochloride

    6. N-benzyl-n-(4,5-dihydro-1h-imidazol-2-ylmethyl)aniline Hydrochloride

    7. Fp8q8f72jh

    8. Mls000028599

    9. Fenazolina

    10. N-benzyl-n-(4,5-dihydro-1h-imidazol-2-ylmethyl)aniline,hydrochloride

    11. N-benzyl-n-((4,5-dihydro-1h-imidazol-2-yl)methyl)aniline Hydrochloride

    12. 2-(n-benzylanilino)methyl-2-imidazoline, Hydrochloride

    13. Histazine

    14. Smr000058731

    15. 2508-72-7 (hcl)

    16. N-benzyl-n-(4,5-dihydro-1h-imidazol-2-ylmethyl)aniline;hydrochloride

    17. Dsstox_cid_27762

    18. Dsstox_rid_82539

    19. Dsstox_gsid_47782

    20. Antazolinium Chloratum

    21. Antistine Hydrochloride

    22. N-benzyl-n-[(4,5-dihydro-1h-imidazol-2-yl)methyl]aniline Hydrochloride

    23. Sr-01000000255

    24. Ncgc00016613-01

    25. Einecs 219-719-8

    26. Cas-2508-72-7

    27. Unii-fp8q8f72jh

    28. Antazoline Hydrochloride [usp]

    29. Phenazocine Hcl

    30. Prestwick_82

    31. 2-phenylbenzylaminomethylimidazoline Hydrochloride

    32. Phenazolinum (tn)

    33. Mfcd00058145

    34. 2-(n-phenyl-n-benzylaminomethyl)imidazoline Hydrochloride

    35. 2-imidazoline, 2-((n-benzylanilino)methyl)-, Monohydrochloride

    36. Opera_id_1387

    37. Antazoline Hydrochloride,(s)

    38. Mls001148371

    39. Mls002153486

    40. Mls002222161

    41. Regid_for_cid_17275

    42. Chembl1256819

    43. Dtxsid1047782

    44. Hms1568d18

    45. Bcp32138

    46. Hy-b1067

    47. Tox21_110524

    48. 2-imidazoline, 2-((n-benzylanilino)methyl)-, Hydrochloride

    49. Antazoline Hydrochloride [mi]

    50. S4199

    51. Akos015916586

    52. Tox21_110524_1

    53. Ac-8174

    54. Ccg-220258

    55. Cs-4623

    56. 4,5-dihydro-n-phenyl-n-(phenylmethyl)-1h-imidazole-2-methanamine Hydrochloride

    57. Antazoline Hcl;phenazoline Hydrochloride

    58. Antazoline Hydrochloride [mart.]

    59. Antazoline Hydrochloride [vandf]

    60. Antazoline Hydrochloride [who-dd]

    61. Ncgc00016613-10

    62. Ncgc00180986-01

    63. 6-(boc-amino)-3-pyridazinecarboxylicacid

    64. As-74198

    65. Sw196394-3

    66. A16411

    67. Antazoline Hydrochloride [ep Monograph]

    68. D07459

    69. H11312

    70. Sr-01000000255-3

    71. Sr-01000000255-6

    72. Q27278115

    73. Antazoline Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

    74. Antazoline Hydrochloride, European Pharmacopoeia (ep) Reference Standard

    75. N-benzyl-n-((4,5-dihydro-1h-imidazol-2-yl)methyl)anilinehydrochloride

    76. 1h-imidazole-2-methanamine, 4,5-dihydro-n-phenyl-n-(phenylmethyl)-, Hydrochloride (1:1)

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 301.8 g/mol
    Molecular Formula C17H20ClN3
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count5
    Exact Mass301.1345753 g/mol
    Monoisotopic Mass301.1345753 g/mol
    Topological Polar Surface Area27.6 Ų
    Heavy Atom Count21
    Formal Charge0
    Complexity314
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Histamine H1 Antagonists

    Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)

    Anti-Allergic Agents

    Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)