loader
Please Wait
Applying Filters...

AbbVie Header AbbVie Header

X
menu

    Market Place

    Market Place

    Post Enquiry

    Post Enquiry
    menu

    Technical details about apatinib mesylate, learn more about the structure, uses, toxicity, action, side effects and more

    Client Email Product
    Menu

    apatinib mesylate

    PRICE INFORMATION

    PharmaCompass

    Naprod is a top player in Oncology & Anesthesia FDF through excellent innovation, discovery of new processes & high-quality production.

    Skyepharma, an Expert and Innovative CDMO Partner for tailor-made solutions in complex oral solids and bioproduction.

    2D Structure
    1. Also known as: 1218779-75-9, Rivoceranib mesylate, Yn968d1, Yn-968d1, Yn 968d1, Tk02x14asj
    Molecular Formula
    C25H27N5O4S
    Molecular Weight
    493.6  g/mol
    InChI Key
    FYJROXRIVQPKRY-UHFFFAOYSA-N
    FDA UNII
    TK02X14ASJ
    Rivoceranib Mesylate is the mesylate salt of rivoceranib, an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities. Rivoceranib selectively binds to and inhibits vascular endothelial growth factor receptor 2, which may inhibit VEGF-stimulated endothelial cell migration and proliferation and decrease tumor microvessel density. In addition, this agent mildly inhibits c-Kit and c-SRC tyrosine kinases.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    N-[4-(1-cyanocyclopentyl)phenyl]-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide;methanesulfonic acid
    2.1.2 InChI
    InChI=1S/C24H23N5O.CH4O3S/c25-17-24(11-1-2-12-24)19-5-7-20(8-6-19)29-23(30)21-4-3-13-27-22(21)28-16-18-9-14-26-15-10-18;1-5(2,3)4/h3-10,13-15H,1-2,11-12,16H2,(H,27,28)(H,29,30);1H3,(H,2,3,4)
    2.1.3 InChI Key
    FYJROXRIVQPKRY-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CS(=O)(=O)O.C1CCC(C1)(C#N)C2=CC=C(C=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4
    2.2 Other Identifiers
    2.2.1 UNII
    TK02X14ASJ
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Apatinib

    2. Rivoceranib

    3. Rivoceranib Mesylate

    4. Yn-968d1

    5. Yn968d1

    2.3.2 Depositor-Supplied Synonyms

    1. 1218779-75-9

    2. Rivoceranib Mesylate

    3. Yn968d1

    4. Yn-968d1

    5. Yn 968d1

    6. Tk02x14asj

    7. Rivoceranib Mesylate (usan)

    8. 3-pyridinecarboxamide, N-(4-(1-cyanocyclopentyl)phenyl)-2-((4-pyridinylmethyl)amino)-, Methanesulfonate (1:1)

    9. Rivoceranib Mesylate [usan]

    10. N-(4-(1-cyanocyclopentyl)phenyl)-2-((pyridin-4-ylmethyl)amino)nicotinamide Mesylate

    11. N-[4-(1-cyanocyclopentyl)phenyl]-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide;methanesulfonic Acid

    12. Unii-tk02x14asj

    13. Apatinib?mesylate

    14. 3-pyridinecarboxamide, N-[4-(1-cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]-, Methanesulfonate (1:1)

    15. Alitan (tn)

    16. Apatinib-yn968d1

    17. Apatinib - Yn968d1

    18. Mls006011286

    19. Chembl3545414

    20. Schembl21847695

    21. Dtxsid80153427

    22. Hms3655h12

    23. Bcp15234

    24. Apatinib (registered Name In China)

    25. Bdbm50152828

    26. S2221

    27. Rivoceranib Mesylate [who-dd]

    28. Akos026750547

    29. Bcp9000308

    30. Ccg-269641

    31. Cs-0694

    32. Sb16589

    33. N-(4-(1-cyanocyclopentyl)phenyl)-2-((pyridin-4-ylmethyl)amino)nicotinamide Methanesulfonate

    34. Ac-35390

    35. Hy-13342

    36. Smr004703036

    37. Sw220296-1

    38. D11289

    39. N-(4-(1-cyanocyclopentyl)phenyl)-2-(pyridin-4-ylmethylamino)nicotinamide Mesylate

    40. N-(4-(1-cyanocyclopentyl)phenyl)-2-((pyridin-4-ylmethyl)amino)pyridine-3-carboxamide Mesylate

    41. N-(4-(1-cyanocyclopentyl)phenyl)-2-((pyridin-4-ylmethyl)amino)pyridine-3-carboxamide Monomethanesulfonate Salt

    2.4 Create Date
    2010-04-26
    3 Chemical and Physical Properties
    Molecular Weight 493.6 g/mol
    Molecular Formula C25H27N5O4S
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count6
    Exact Mass493.17837553 g/mol
    Monoisotopic Mass493.17837553 g/mol
    Topological Polar Surface Area153 Ų
    Heavy Atom Count35
    Formal Charge0
    Complexity701
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antineoplastic Agents

    Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)

    Protein Kinase Inhibitors

    Agents that inhibit PROTEIN KINASES. (See all compounds classified as Protein Kinase Inhibitors.)

    Post Enquiry
    POST ENQUIRY