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    Apomorphine Hydrochloride

    ACTIVE PHARMA INGREDIENTS

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    2D Structure
    Also known as: 314-19-2, Apomorphine hcl, Apomorphine chloride, (r)-(-)-apomorphine hydrochloride, Apokinon, Apomorphinium chloride
    Molecular Formula
    C17H18ClNO2
    Molecular Weight
    303.8  g/mol
    InChI Key
    SKYZYDSNJIOXRL-BTQNPOSSSA-N
    FDA UNII
    9K13MD7A0D
    A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poisoning. It has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its use.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol;hydrochloride
    2.1.2 InChI
    InChI=1S/C17H17NO2.ClH/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12;/h2-6,13,19-20H,7-9H2,1H3;1H/t13-;/m1./s1
    2.1.3 InChI Key
    SKYZYDSNJIOXRL-BTQNPOSSSA-N
    2.1.4 Canonical SMILES
    CN1CCC2=C3C1CC4=C(C3=CC=C2)C(=C(C=C4)O)O.Cl
    2.1.5 Isomeric SMILES
    CN1CCC2=C3[C@H]1CC4=C(C3=CC=C2)C(=C(C=C4)O)O.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    9K13MD7A0D
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Apokinon

    2. Apomorphin Teclapharm

    3. Apomorphin-teclapharm

    4. Apomorphine

    5. Apomorphine Chloride

    6. Apomorphine Hydrochloride Anhydrous

    7. Apomorphine Hydrochloride, Anhydrous

    8. Apomorphine Hydrochloride, Hemihydrate

    9. Britaject

    2.3.2 Depositor-Supplied Synonyms

    1. 314-19-2

    2. Apomorphine Hcl

    3. Apomorphine Chloride

    4. (r)-(-)-apomorphine Hydrochloride

    5. Apokinon

    6. Apomorphinium Chloride

    7. Apomorphine Hydrochloride Anhydrous

    8. Uprima

    9. N-methylnorapomorphine Hydrochloride

    10. Nsc-11442

    11. 9k13md7a0d

    12. Apomorphine Sl

    13. Taluvian

    14. Ixense

    15. 41372-20-7

    16. Apomorphine Hydrochloride Hemihydrate

    17. Apomorphinum Muriaticum

    18. Apomorphin Hydrochlorid

    19. (-)-apomorphine Hydrochloride

    20. Britaject

    21. Pomorphini Hydrochloridum

    22. Apomorphinum Hydrochloricum

    23. Apomorphine Hydrochloride Hydrate

    24. Kw-6500

    25. (-)-apomorphinium Hydrochloride

    26. Nsc-755875

    27. Einecs 206-243-0

    28. Nsc 11442

    29. Unii-9k13md7a0d

    30. Apomorphine-hcl

    31. Apomorphinehydrochloride

    32. 6a-beta-aporphine-10,11-diol, Hydrochloride

    33. (6ar)-6-methyl-5,6,6a,7-tetrahydro-4h-dibenzo[de,g]quinoline-10,11-diol Hydrochloride

    34. Prestwick_28

    35. 6abeta-noraporphine-10,11-diol, 6-methyl-, Hydrochloride

    36. 6a-beta-noraporphine-10,11-diol, 6-methyl-, Hydrochloride

    37. R-(-)-apomorphine Hcl

    38. 6abeta-aporphine-10,11-diol, Hydrochloride

    39. 5,6,6a,7-tetrahydro-6-methyl-4h-dibenzo(de,g)chinolin-10,11-diol Hydrochlorid

    40. Schembl8524

    41. Chembl1616

    42. (r)-(-)-apomorphine Hcl

    43. Dtxsid5040598

    44. Apomorphine Hydrochloride (r,-)

    45. Apomorphine, Hydrochloride

    46. R-(-)-apomorphine Hydrochloride

    47. (-)-apomorphine (hydrochloride)

    48. (r)-6-methyl-5,6,6a,7-tetrahydro-4h-dibenzo[de,g]quinoline-10,11-diol Hydrochloride

    49. Anhydrous Apomorphine Hydrochloride

    50. Nsc11442

    51. Apomorphine Hydrochloride [mi]

    52. 6a.beta.-aporphine-10, Hydrochloride

    53. Akos024456928

    54. H72a207

    55. 4h-dibenzo(de,g)quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, Hydrochloride, (6ar)-

    56. 4h-dibenzo(de,g)quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, Hydrochloride, (r)-

    57. B6936

    58. Sr-01000597777

    59. J-018414

    60. Sr-01000597777-1

    61. 6a.beta.-aporphine-10,11-diol Hydrochloride

    62. 6a.beta.-noraporphine-10, 6-methyl-, Hydrochloride

    63. Q27272658

    64. Wln: T C6666 1a Q Kn & Tt & J Dq Eq K1 & Gh

    65. (r)-5,6,6a,7-tetrahydro-6-methyl-4h-dibenzo[de,g]quinoline-10,11-diol Hydrochloride

    66. 4h-dibenzo[de,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, Hydrochloride, (r)-

    67. (6ar)-5,6,6a,7-tetrahydro-6-methyl-4h-dibenzo(de,g)quinoline-10,11-diol Hydrochloride

    68. 4h-dibenzo(de,g)quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, Hydrochloride (1:1), (6ar)-

    2.3.3 Other Synonyms

    1. Apomorphine Hydrochloride Hydrate

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 303.8 g/mol
    Molecular Formula C17H18ClNO2
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count0
    Exact Mass303.1026065 g/mol
    Monoisotopic Mass303.1026065 g/mol
    Topological Polar Surface Area43.7 Ų
    Heavy Atom Count21
    Formal Charge0
    Complexity374
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Indication

    Treatment of men with erectile dysfunction, which is the inability to achieve or maintain a penile erection sufficient for satisfactory sexual performance.

    In order for Uprima to be effective, sexual stimulation is required.

    Treatment of men with erectile dysfunction, which is the inability to achieve or maintain a penile erection sufficient for satisfactory sexual performance.

    In order for Taluvian to be effective, sexual stimulation is required.

    Treatment of men with erectile dysfunction, which is the inability to achieve or maintain a penile erection sufficient for satisfactory sexual performance.

    In order for Ixense to be effective, sexual stimulation is required.

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Dopamine Agonists

    Drugs that bind to and activate dopamine receptors. (See all compounds classified as Dopamine Agonists.)

    Emetics

    Agents that cause vomiting. They may act directly on the gastrointestinal tract, bringing about emesis through local irritant effects, or indirectly, through their effects on the chemoreceptor trigger zone in the postremal area near the medulla. (See all compounds classified as Emetics.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Dopaminergic Agonist [EPC]; Dopamine Agonists [MoA]
    5.3 ATC Code

    G04BE

    G04BE

    G04BE