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    Aprindine Hydrochloride

    ACTIVE PHARMA INGREDIENTS

    PharmaCompass
    $ API Ref.Price (USD/KG) : 938Xls

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    2D Structure
    Also known as: Aprindine hcl, 33237-74-0, Aspenon, Fibocil, Compound 83846, Aprinidine chloride
    Molecular Formula
    C22H31ClN2
    Molecular Weight
    358.9  g/mol
    InChI Key
    KIPFVRHNAAZJOD-UHFFFAOYSA-N
    FDA UNII
    PB5EKT7Q2V
    A class Ib anti-arrhythmia agent used to manage ventricular and supraventricular arrhythmias.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    N'-(2,3-dihydro-1H-inden-2-yl)-N,N-diethyl-N'-phenylpropane-1,3-diamine;hydrochloride
    2.1.2 InChI
    InChI=1S/C22H30N2.ClH/c1-3-23(4-2)15-10-16-24(21-13-6-5-7-14-21)22-17-19-11-8-9-12-20(19)18-22;/h5-9,11-14,22H,3-4,10,15-18H2,1-2H3;1H
    2.1.3 InChI Key
    KIPFVRHNAAZJOD-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCN(CC)CCCN(C1CC2=CC=CC=C2C1)C3=CC=CC=C3.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    PB5EKT7Q2V
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Amidonal

    2. Aprindine

    3. Fiboran

    2.3.2 Depositor-Supplied Synonyms

    1. Aprindine Hcl

    2. 33237-74-0

    3. Aspenon

    4. Fibocil

    5. Compound 83846

    6. Aprinidine Chloride

    7. Amidonal

    8. Aprindinehcl

    9. Aprindine (hydrochloride)

    10. Pb5ekt7q2v

    11. N-(2,3-dihydro-1h-inden-2-yl)-n',n'-diethyl-n-phenyl-1,3-propanediamine Hydrochloride

    12. Nsc-284614

    13. Fiboran

    14. Ritmusin

    15. 33237-74-0 (hcl)

    16. Dsstox_cid_26726

    17. Dsstox_rid_81856

    18. Dsstox_gsid_46726

    19. Lilly 83846

    20. N'-(2,3-dihydro-1h-inden-2-yl)-n,n-diethyl-n'-phenylpropane-1,3-diamine;hydrochloride

    21. Cas-33237-74-0

    22. Ccris 5480

    23. Ncgc00167576-01

    24. Aprindine Hydrochloride [usan:jan]

    25. Einecs 251-418-7

    26. Unii-pb5ekt7q2v

    27. Nsc 284614

    28. Ms 5075

    29. Ms-5075

    30. Aspenon (tn)

    31. N-(2,3-dihydro-1h-inden-2-yl)-n',n'-diethyl-n-phenylpropane-1,3-diamine Monohydrochloride

    32. 2-indanamine, N-(3-(diethylamino)propyl)-n-phenyl-, Hydrochloride

    33. N,n-diethyl-n'-2-indanyl-n'-phenyl-1,3-propanediamine Hydrochloride

    34. N,n-diethyl-n'-2-indanyl-n'-phenyl-1,3-propanediamine Monohydrochloride

    35. 1,3-propanediamine, N-(2,3-dihydro-1h-inden-2-yl)-n',n'-diethyl-n-phenyl-, Monohydrochloride

    36. Compound-83846

    37. Mls004712062

    38. Schembl122403

    39. Chembl2104501

    40. Dtxsid5046726

    41. Chebi:31229

    42. Hy-a0236a

    43. Aprindine Hydrochloride [mi]

    44. Tox21_112569

    45. Tox21_501190

    46. Aprindine Hydrochloride [jan]

    47. Aprindine Hydrochloride [usan]

    48. 1,3-propanediamine, N,n-diethyl-n'-2-indanyl-n'-phenyl-, Monohydrochloride

    49. Akos015994694

    50. Aprindine Hydrochloride (jp17/usan)

    51. Tox21_112569_1

    52. Aprindine Hydrochloride [mart.]

    53. Ccg-222494

    54. Ks-1222

    55. Lp01190

    56. Aprindine Hydrochloride [who-dd]

    57. Ncgc00167576-02

    58. Ncgc00261875-01

    59. Smr001456520

    60. Cs-0133610

    61. D01326

    62. Aprindine Hydrochloride, >=98% (hplc), Solid

    63. J-019105

    64. Q27286446

    65. N1-(2,3-dihydro-1h-inden-2-yl)-n3,n3-diethyl-n1-phenylpropane-1,3-diamine Hydrochloride

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 358.9 g/mol
    Molecular Formula C22H31ClN2
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count8
    Exact Mass358.2175767 g/mol
    Monoisotopic Mass358.2175767 g/mol
    Topological Polar Surface Area6.5 Ų
    Heavy Atom Count25
    Formal Charge0
    Complexity332
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-Arrhythmia Agents

    Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)

    Voltage-Gated Sodium Channel Blockers

    A class of drugs that inhibit the activation of VOLTAGE-GATED SODIUM CHANNELS. (See all compounds classified as Voltage-Gated Sodium Channel Blockers.)