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    Apropovir

    ACTIVE PHARMA INGREDIENTS

    DIGITAL CONTENT

    PharmaCompass
    Xls

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    2D Structure
    Also known as: 107021-12-5, Tenofovir-d6, Apropovir, 1-(6-aminopurin-9-yl)propan-2-yloxymethylphosphonic acid, (((1-(6-amino-9h-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic acid, ({[1-(6-amino-9h-purin-9-yl)propan-2-yl]oxy}methyl)phosphonic acid
    Molecular Formula
    C9H14N5O4P
    Molecular Weight
    287.21  g/mol
    InChI Key
    SGOIRFVFHAKUTI-UHFFFAOYSA-N
    An adenine analog REVERSE TRANSCRIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B. It is used to treat HIV INFECTIONS and CHRONIC HEPATITIS B, in combination with other ANTIVIRAL AGENTS, due to the emergence of ANTIVIRAL DRUG RESISTANCE when it is used alone.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-(6-aminopurin-9-yl)propan-2-yloxymethylphosphonic acid
    2.1.2 InChI
    InChI=1S/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)
    2.1.3 InChI Key
    SGOIRFVFHAKUTI-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC(CN1C=NC2=C(N=CN=C21)N)OCP(=O)(O)O
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. (r)-9-(2-phosphonylmethoxypropyl)adenine

    2. 9-(2-phosphonylmethoxypropyl)adenine

    3. 9-(2-phosphonylmethoxypropyl)adenine, (+-)-isomer

    4. 9-(2-phosphonylmethoxypropyl)adenine, (r)-isomer - T357098

    5. 9-(2-phosphonylmethoxypropyl)adenine, (s)-isomer

    6. 9-pmpa (tenofovir)

    7. Disoproxil Fumarate, Tenofovir

    8. Disoproxil, Tenofovir

    9. Fumarate, Tenofovir Disoproxil

    10. Tenofovir

    11. Tenofovir Disoproxil

    12. Tenofovir Disoproxil Fumarate

    13. Viread

    2.2.2 Depositor-Supplied Synonyms

    1. 107021-12-5

    2. Tenofovir-d6

    3. Apropovir

    4. 1-(6-aminopurin-9-yl)propan-2-yloxymethylphosphonic Acid

    5. (((1-(6-amino-9h-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic Acid

    6. ({[1-(6-amino-9h-purin-9-yl)propan-2-yl]oxy}methyl)phosphonic Acid

    7. 1217720-14-3

    8. Tenofovir (parent)

    9. Mfcd21604708

    10. ((2-(6-amino-9h-purin-9-yl)-1-methylethoxy)methyl)phosphonic Acid

    11. Mls006011450

    12. Schembl497725

    13. Chembl315593

    14. Dtxsid30861388

    15. Bcp02416

    16. Vqb71994

    17. Bbl032950

    18. Stl370337

    19. 9-[2-(phosphonomethoxy)propyl]adenine

    20. Akos015961830

    21. Phosphonic Acid, ((2-(6-amino-9h-purin-9-yl)-1-methylethoxy)methyl)-

    22. Smr004703253

    23. Sy115900

    24. Ft-0601652

    25. Ft-0674851

    26. Ft-0696939

    27. 9-[2-(phosphonomethoxy)propyl]-9h-purin-6-amine

    28. A851347

    29. (r)-pmpa;gs-1278;gs 1278;gs1278;tdf;pmpa

    30. (s)-[[[1-(6-amino-9h-purin-9-yl)-2-propyl]oxy]methyl]phosphonic Acid

    2.3 Create Date
    2005-08-01
    3 Chemical and Physical Properties
    Molecular Weight 287.21 g/mol
    Molecular Formula C9H14N5O4P
    XLogP3-1.6
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count5
    Exact Mass287.07834094 g/mol
    Monoisotopic Mass287.07834094 g/mol
    Topological Polar Surface Area136 Ų
    Heavy Atom Count19
    Formal Charge0
    Complexity354
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-HIV Agents

    Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS. (See all compounds classified as Anti-HIV Agents.)

    Reverse Transcriptase Inhibitors

    Inhibitors of reverse transcriptase (RNA-DIRECTED DNA POLYMERASE), an enzyme that synthesizes DNA on an RNA template. (See all compounds classified as Reverse Transcriptase Inhibitors.)

    Antiviral Agents

    Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)