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    Atomoxetin Hydrochloride

    ACTIVE PHARMA INGREDIENTS

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    $ API Ref.Price (USD/KG) : 827Xls

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    2D Structure
    Also known as: Atomoxetine hcl, 82248-59-7, Tomoxetine hydrochloride, Strattera, (r)-tomoxetine hydrochloride, (r)-n-methyl-3-phenyl-3-(o-tolyloxy)propan-1-amine hydrochloride
    Molecular Formula
    C17H22ClNO
    Molecular Weight
    291.8  g/mol
    InChI Key
    LUCXVPAZUDVVBT-UNTBIKODSA-N
    FDA UNII
    57WVB6I2W0
    A propylamine derivative and selective ADRENERGIC UPTAKE INHIBITOR that is used in the treatment of ATTENTION DEFICIT HYPERACTIVITY DISORDER.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (3R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine;hydrochloride
    2.1.2 InChI
    InChI=1S/C17H21NO.ClH/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15;/h3-11,17-18H,12-13H2,1-2H3;1H/t17-;/m1./s1
    2.1.3 InChI Key
    LUCXVPAZUDVVBT-UNTBIKODSA-N
    2.1.4 Canonical SMILES
    CC1=CC=CC=C1OC(CCNC)C2=CC=CC=C2.Cl
    2.1.5 Isomeric SMILES
    CC1=CC=CC=C1O[C@H](CCNC)C2=CC=CC=C2.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    57WVB6I2W0
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 139603, Ly

    2. Atomoxetine

    3. Atomoxetine Hcl

    4. Hcl, Atomoxetine

    5. Hydrochloride, Atomoxetine

    6. Ly 139603

    7. N-methyl-gamma-(2-methylphenoxy)benzenepropanamine Hydrochloride

    8. Strattera

    9. Tomoxetine

    10. Tomoxetine Hydrochloride, (+)-isomer - T351671

    11. Tomoxetine Hydrochloride, (+-)-isomer

    12. Tomoxetine Hydrochloride, (-)-isomer

    2.3.2 Depositor-Supplied Synonyms

    1. Atomoxetine Hcl

    2. 82248-59-7

    3. Tomoxetine Hydrochloride

    4. Strattera

    5. (r)-tomoxetine Hydrochloride

    6. (r)-n-methyl-3-phenyl-3-(o-tolyloxy)propan-1-amine Hydrochloride

    7. Atomoxetine, Hcl

    8. Atomoxetine Hydrochloride [usan]

    9. (r)-(-)-tomoxetine Hydrochloride

    10. Ly 139603

    11. Atomoxetine (hydrochloride)

    12. Ly-139603

    13. Atomoxetine (as Hydrochloride)

    14. 57wvb6i2w0

    15. (-)-n-methyl-3-phenyl-3-(o-tolyloxy)propylamine Hydrochloride

    16. Chebi:331697

    17. (r)-atomoxetine Hydrochloride

    18. Nsc-759104

    19. Dsstox_cid_24266

    20. Dsstox_rid_80136

    21. Dsstox_gsid_44266

    22. Smr000469177

    23. Cas-82248-59-7

    24. Unii-57wvb6i2w0

    25. (3r)-n-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine;hydrochloride

    26. Strattera (tn)

    27. Mfcd06410992

    28. Ncgc00016056-02

    29. Chembl1702

    30. Mls001401377

    31. Mls002153176

    32. Schembl122111

    33. Atomoxetine Hcl [vandf]

    34. Dtxsid2044266

    35. Atomoxetine Hydrochloride- Bio-x

    36. Atomoxetine Hydrochloride Solution

    37. Ly 139603 Hcl

    38. Hms3413c05

    39. Hms3677c05

    40. (r)-n-methyl-3-phenyl-3-(o-tolyloxy)propan-1-aminehydrochloride

    41. (r)-tomoxetine Hydrochloride, Solid

    42. Tox21_110292

    43. Atomoxetine Hydrochloride (jan/usp)

    44. Ly-139602 [(+)-isomer]

    45. S3175

    46. Atomoxetine Hydrochloride [mi]

    47. (3r)-n-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine Hydrochloride

    48. Akos015920150

    49. Benzenepropanamine, N-methyl-gamma-(2-methylphenoxy)-, Hydrochloride, (-)-

    50. Tox21_110292_1

    51. Atomoxetine Hydrochloride [jan]

    52. Ccg-100874

    53. Cs-1085

    54. Ks-1223

    55. Nc00124

    56. Nsc 759104

    57. Atomoxetine For Impurity A Identification

    58. Atomoxetine Hydrochloride [mart.]

    59. Ncgc00025345-02

    60. Atomoxetine Hydrochloride [usp-rs]

    61. Atomoxetine Hydrochloride [who-dd]

    62. Bm164222

    63. Hy-17385

    64. Ly-135252

    65. Am20060733

    66. Sw197504-3

    67. Atomoxetine Hydrochloride [ep Monograph]

    68. Atomoxetine Hydrochloride [orange Book]

    69. D02574

    70. Atomoxetine Hydrochloride [usp Monograph]

    71. 248t597

    72. Sr-01000597779

    73. Sr-01000763397

    74. Sr-01000597779-1

    75. Sr-01000763397-3

    76. Q27225729

    77. F0001-2408

    78. Atomoxetine Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

    79. (r)-n-methyl-?-(2-methylphenoxy)-benzenepropanamine Hydrochloride

    80. (r)-n-methyl-3-(2-methylphenoxy)-3-phenylpropylamine Hydrochloride

    81. (r)-n-methyl-3-phenyl-3-(o-tolyloxy)-propan-1-amine Hydrochloride

    82. (r)-n-methyl-3-phenyl-3-(o-tolyloxy)propan-1-amine Hcl

    83. (r)-(-)-n-methyl-3-(2-methylphenoxy)-3-phenylpropylamine Hydrochloride

    84. (r)-n-methyl-gamma-(2-methylphenoxy)-benzenepropanamine Hydrochloride

    85. Atomoxetine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

    86. Methyl-((r)-3-phenyl-3-o-tolyloxy-propyl)-amine Hydrochloride

    87. Atomoxetine For Impurity A Identification, European Pharmacopoeia (ep) Reference Standard

    88. Atomoxetine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

    89. Atomoxetine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    90. Benzenepropanamine, N-methyl-.gamma.-(2-methylphenoxy)-, Hydrochloride, (-)

    91. Atomoxetine Hydrochloride Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 291.8 g/mol
    Molecular Formula C17H22ClNO
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count6
    Exact Mass291.1389920 g/mol
    Monoisotopic Mass291.1389920 g/mol
    Topological Polar Surface Area21.3 Ų
    Heavy Atom Count20
    Formal Charge0
    Complexity237
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameAtomoxetine hydrochloride
    Drug LabelSTRATTERA (atomoxetineHCl) is a selective norepinephrine reuptake inhibitor. AtomoxetineHCl is the R(-) isomer as determined by xray diffraction. The chemical designation is (-)-N-Methyl-3-phenyl-3-(o-tolyloxy)-propylamine hydrochloride. The...
    Active IngredientAtomoxetine hydrochloride
    Dosage FormCapsule
    Routeoral
    Strength18mg; 100mg; 25mg; 60mg; 10mg; 80mg; 40mg
    Market StatusTentative Approval
    CompanyMylan Pharms; Glenmark Generics; Aurobindo Pharma Usa; Apotex; Dr Reddys Labs; Sandoz; Sun Pharma Global

    2 of 4  
    Drug NameStrattera
    PubMed HealthAtomoxetine (By mouth)
    Drug ClassesCentral Nervous System Agent
    Drug LabelSTRATTERA (atomoxetineHCl) is a selective norepinephrine reuptake inhibitor. AtomoxetineHCl is the R(-) isomer as determined by x-ray diffraction. The chemical designation is (-)-N-Methyl-3-phenyl-3-(o-tolyloxy)-propylamine hydrochloride. The m...
    Active IngredientAtomoxetine hydrochloride
    Dosage FormCapsule
    RouteOral
    Strength18mg; 25mg; 100mg; 60mg; 10mg; 80mg; 40mg
    Market StatusPrescription
    CompanyLilly

    3 of 4  
    Drug NameAtomoxetine hydrochloride
    Drug LabelSTRATTERA (atomoxetineHCl) is a selective norepinephrine reuptake inhibitor. AtomoxetineHCl is the R(-) isomer as determined by xray diffraction. The chemical designation is (-)-N-Methyl-3-phenyl-3-(o-tolyloxy)-propylamine hydrochloride. The...
    Active IngredientAtomoxetine hydrochloride
    Dosage FormCapsule
    Routeoral
    Strength18mg; 100mg; 25mg; 60mg; 10mg; 80mg; 40mg
    Market StatusTentative Approval
    CompanyMylan Pharms; Glenmark Generics; Aurobindo Pharma Usa; Apotex; Dr Reddys Labs; Sandoz; Sun Pharma Global

    4 of 4  
    Drug NameStrattera
    PubMed HealthAtomoxetine (By mouth)
    Drug ClassesCentral Nervous System Agent
    Drug LabelSTRATTERA (atomoxetineHCl) is a selective norepinephrine reuptake inhibitor. AtomoxetineHCl is the R(-) isomer as determined by x-ray diffraction. The chemical designation is (-)-N-Methyl-3-phenyl-3-(o-tolyloxy)-propylamine hydrochloride. The m...
    Active IngredientAtomoxetine hydrochloride
    Dosage FormCapsule
    RouteOral
    Strength18mg; 25mg; 100mg; 60mg; 10mg; 80mg; 40mg
    Market StatusPrescription
    CompanyLilly

    4.2 Drug Indication

    Treatment of Attention Deficit Hyperactivity Disorder (ADHD)

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Adrenergic Uptake Inhibitors

    Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. (See all compounds classified as Adrenergic Uptake Inhibitors.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Norepinephrine Uptake Inhibitors [MoA]; Norepinephrine Reuptake Inhibitor [EPC]