1. Pyridoxin
2. Pyridoxine
3. Pyridoxol
4. Pyridoxol Hydrochloride
5. Rodex
1. 58-56-0
2. Pyridoxine Hcl
3. Pyridoxol Hydrochloride
4. Vitamin B6
5. Vitamin B6 Hydrochloride
6. Pyridoxine Chloride
7. Hexa-betalin
8. Alestrol
9. Becilan
10. Benadon
11. Hexavibex
12. Hexermin
13. Hexobion
14. Pyridipca
15. Beesix
16. Pydox
17. Adermine Hydrochloride
18. Campoviton 6
19. Aderoxine
20. Pyridoxinium Chloride
21. Aderomine Hydrochloride
22. Hexabione Hydrochloride
23. Pyridoxin Hydrochloride
24. Pyridoxinum Hydrochloricum
25. 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol Hydrochloride
26. Bendectin
27. 3,4-pyridinedimethanol, 5-hydroxy-6-methyl-, Hydrochloride
28. Pyridoxol, Hydrochloride
29. Pyridoxine (hydrochloride)
30. 5-hydroxy-6-methyl-3,4-pyridinedimethanol Hydrochloride
31. Mfcd00012807
32. 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine Hydrochloride
33. 3-hydroxy-4,5-dimethylol-alpha-picoline Hydrochloride
34. 5-hydroxy-6-methyl-3,4-pyridinedicarbinol Hydrochloride
35. 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol;hydrochloride
36. Bonasanit
37. (5-hydroxy-6-methylpyridine-3,4-diyl)dimethanol Hydrochloride
38. Nsc-36225
39. Adermin Hydrochloride
40. 5-hydroxy-6-methyl-3,4-pyridinedimethanol, Hydrochloride
41. 68y4cf58bv
42. Hexabetalin
43. Aderoxin
44. Godabion
45. Paxadon
46. Pyridox
47. Chebi:30961
48. Pyridoxine Hydrogen Chloride
49. 8064-77-5
50. Hexa-betalin (r)
51. Spondylonal
52. Rodex (r)
53. Pn Hcl
54. Pyridoxin Hydrochloride (vitamin B6 Hydrochloride)
55. Pyridoxine Monohydrochloride
56. Pyridoxol (hydrochloride);vitamin B6 (hydrochloride)
57. 4,5-bis(hydroxymethyl)-2-methyl-3-pyridinol Hydrochloride
58. Pyridoxine, Hydrochloride
59. 3,4-pyridinedimethanol, 5-hydroxy-6-methyl-, Hydrochloride (1:1)
60. Pyridoxinum Hydrochloricum (hungarian)
61. Smr000674613
62. Hexa-betalin (tn)
63. Nsc36225
64. Ccris 1903
65. Component Of Alestrol
66. Hsdb 1212
67. Tex Six T.r.
68. Clorhidrato De Piridoxina
69. Ncgc00164317-01
70. Vitamin B6-hydrochloride
71. Einecs 200-386-2
72. Nsc 36225
73. Unii-68y4cf58bv
74. Ai3-19016
75. Pyridoxine Hydrochloride [jan]
76. 3-hydroxy-4,5-dihydroxymethyl-2-methylpyridine Hydrochloride
77. Prestwick_925
78. Pyridoxine Hydrochloride [usp:jan]
79. Pyridoxini Hydrochloridum
80. 4,5-bis(hydroxymethyl)-3-hydroxy-2-methylpyridine Hydrochloride
81. Pyridoxol (hydrochloride)
82. Vitamin B6, Hydrochloride
83. Vitamin B6 (hydrochloride)
84. Dsstox_cid_10780
85. Dsstox_rid_79601
86. Dsstox_gsid_40792
87. Schembl42293
88. Mls001074329
89. Mls002153915
90. Pyridoxine Hcl [inci]
91. Pyridoxine Hcl [vandf]
92. Pyridoxine Hydrochloride, 98%
93. 3-hydroxy-4,5-dimethylol-.alpha.-picoline Hydrochloride
94. Chembl1200756
95. Dtxsid1040792
96. Hms1569n08
97. Amy37035
98. Hy-n0682
99. Tox21_302476
100. Pyridoxine Hydrochloride [mi]
101. S3113
102. 3-hydroxy-4,5-dimethylol-alpha-pic
103. Pyridoxine Hydrochloride (jp17/usp)
104. Pyridoxine Hydrochloride [fcc]
105. Akos015891679
106. Pyridoxine Hcl (vitamin B6) Solution
107. Ccg-220623
108. Cs-w020418
109. Pyridoxine Hydrochloride [hsdb]
110. 3, 5-hydroxy-6-methyl-, Hydrochloride
111. Pyridoxine Hydrochloride [mart.]
112. Pyridoxine Hydrochloride [vandf]
113. Ncgc00180946-01
114. Ncgc00256911-01
115. Pyridoxine Hydrochloride [usp-rs]
116. Pyridoxine Hydrochloride [who-dd]
117. Pyridoxine Hydrochloride [who-ip]
118. Pyridoxinum Hydrochloricum [hpus]
119. Ac-12024
120. As-11752
121. Sy061587
122. Wln: T6nj B1 Cq D1q E1q &gh
123. Pyridoxine Hydrochloride, >=98% (hplc)
124. Db-053225
125. Pyridoxine Hydrochloride, P.a., 98-102%
126. B2017
127. Ft-0631260
128. P0561
129. Pyridoxine Hydrochloride [green Book]
130. Sw197042-3
131. Tpn Component Pyridoxine Hydrochloride
132. Pyridoxine Hydrochloride [ep Impurity]
133. Pyridoxine Hydrochloride [orange Book]
134. D02179
135. H12039
136. Pyridoxine Hydrochloride [ep Monograph]
137. Pyridoxine Hydrochloride [usp Monograph]
138. Pyridoxine Hydrochloride Component Of Tpn
139. Pyridoxini Hydrochloridum [who-ip Latin]
140. Vitamin B6 (as Pyridoxine Hydrochloride)
141. Bendectin Component Pyridoxine Hydrochloride
142. Bonjesta Component Pyridoxine Hydrochloride
143. Diclectin Component Pyridoxine Hydrochloride
144. Diclegis Component Pyridoxine Hydrochloride
145. Pyridoxine Hydrochloride (b6), Analytical Standard
146. Pyridoxine Hydrochloride, Plant Cell Culture Tested
147. Q-201647
148. Sr-05000001644-4
149. Pyridoxine Hydrochloride Component Of Bendectin
150. Pyridoxine Hydrochloride Component Of Bonjesta
151. Q26841284
152. F0001-2400
153. Pyridoxine Hydrochloride, Saj Special Grade, >=98.0%
154. Pyridoxine Hydrochloride, Vetec(tm) Reagent Grade, 98%
155. Pyridoxine Hydrochloride, Meets Usp Testing Specifications
156. Pyridoxine Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)
157. 3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine Hydrochloride
158. Pyridoxine Hydrochloride, Certified Reference Material, Tracecert(r)
159. Pyridoxine Hydrochloride, British Pharmacopoeia (bp) Reference Standard
160. Pyridoxine Hydrochloride, European Pharmacopoeia (ep) Reference Standard
161. Pyridoxin Hydrochloride (vitamin B6 Hydrochloride) 100 Microg/ml In Methanol
162. Pyridoxine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material
163. Pyridoxine Hydrochloride, United States Pharmacopeia (usp) Reference Standard
164. Pyridoxine Hcl (vitamin B6) Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material
165. Pyridoxine Hydrochloride, Bioreagent, Suitable For Cell Culture, Suitable For Insect Cell Culture, Suitable For Plant Cell Culture
166. Pyridoxine Hydrochloride, Pharmagrade, Ep, Manufactured Under Appropriate Gmp Controls For Pharma Or Biopharmaceutical Production
| Molecular Weight | 205.64 g/mol |
|---|---|
| Molecular Formula | C8H12ClNO3 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 2 |
| Exact Mass | 205.0505709 g/mol |
| Monoisotopic Mass | 205.0505709 g/mol |
| Topological Polar Surface Area | 73.6 Ų |
| Heavy Atom Count | 13 |
| Formal Charge | 0 |
| Complexity | 142 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 2 |
| 1 of 2 | |
|---|---|
| Drug Name | Pyridoxine hydrochloride |
| Drug Label | Pyridoxine Hydrochloride Injection, USP is a sterile solution of pyridoxine hydrochloride in Water for Injection. Each mL contains 100 mg pyridoxine hydrochloride and 0.5% chlorobutanol anhydrous (chloral deriv.). pH adjusted with sodium hydroxid... |
| Active Ingredient | Pyridoxine hydrochloride |
| Dosage Form | Injectable |
| Route | Injection |
| Strength | 100mg/ml |
| Market Status | Prescription |
| Company | Fresenius Kabi Usa |
| 2 of 2 | |
|---|---|
| Drug Name | Pyridoxine hydrochloride |
| Drug Label | Pyridoxine Hydrochloride Injection, USP is a sterile solution of pyridoxine hydrochloride in Water for Injection. Each mL contains 100 mg pyridoxine hydrochloride and 0.5% chlorobutanol anhydrous (chloral deriv.). pH adjusted with sodium hydroxid... |
| Active Ingredient | Pyridoxine hydrochloride |
| Dosage Form | Injectable |
| Route | Injection |
| Strength | 100mg/ml |
| Market Status | Prescription |
| Company | Fresenius Kabi Usa |
DOSE: USUAL, ORAL OR PARENTERAL, PROPHYLACTIC, 2 MG ONCE A DAY; THERAPEUTIC, 5 TO 150 MG DAILY. DOSE FOR MALNUTRITION IS 5 TO 10 MG DAILY; FOR HYPEREMESIS GRAVIDUM & EMESIS OF RADIATION SICKNESS IS 10 TO 100 MG DAILY.
Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 960
... MAY BE USED PROPHYLACTICALLY TO PREVENT PERIPHERAL NEURITIS IN PATIENTS TREATED WITH ISONIAZID. APPEARS TO AID IN DISSOLUTION OF RENAL STONES OF CALCIUM OXALATE ... INCR EXCRETION OF CALCIUM-CHELATING CITRIC ACID.
Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 960
MEDICATION (VET): ... ANTIDOTAL IN MICE & DOGS TO CONVULSIVE EFFECTS OF RODENTICIDE CRIMIDINE.
Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 647
... INFANTS MAY EXHIBIT HYPERIRRITABILITY & EPILEPTIFORM CONVULSIONS DURING FIRST WK OF LIFE THAT PROMPTLY RESPOND TO ADMIN OF PYRIDOXINE. IF UNTREATED, PYRIDOXINE-RESPONSIVE ANEMIA & MENTAL RETARDATION MAY RESULT. /PYRIDOXINE/
American Medical Association, AMA Department of Drugs. AMA Drug Evaluations. 4th ed. Chicago: American Medical Association, 1980., p. 823
For more Therapeutic Uses (Complete) data for PYRIDOXINE HYDROCHLORIDE (22 total), please visit the HSDB record page.
Pyridoxine is usually nontoxic; however, chronic admin of large dosages has been assoc with adverse neurologic effects. Nausea, headache, paresthesia, somnolence, & incr serum AST (SGOT) & decr serum folic acid concn have been reported. Burning or stinging at the injection site may occur following IM or subcutaneous injection of pyridoxine. Seizures have occurred following IV admin of very large doses. Allergic reactions have been reported occasionally in patients receiving the vitamin.
McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 2000.Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2000 (Plus Supplements)., p. 3319
Pyridoxine should not be used in patients with a history of sensitivity to the vitamin. According to one manufacturer, pyridoxine should not be administered iv to patients with heart disease.
McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 2000.Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2000 (Plus Supplements)., p. 3319
Maternal Medication usually Compatible with Breast-Feeding: B6 (pyridoxine): Reported Sign or Symptom in Infant or Effect on Lactation: None. /from Table 6/
Report of the American Academy of Pediatrics Committee on Drugs in Pediatrics 93 (1): 140 (1994)
Very large doses of pyridoxine have been reported to have a lactation-inhibiting effect. Using oral doses of 600 mg/day, lactation was successfully inhibited in 95% of patients within 1 week as compared to only 17% of placebo-treated controls. /Pyridoxine/
Briggs, G.G, R.K. Freeman, S.J. Yaffe. A Reference Guide to Fetal and Neonatal Risk. Drugs in Pregnancy and Lactation. 4th ed. Baltimore, MD: Williams & Wilkins 1994., p. 751
Vitamin B Complex
A group of water-soluble vitamins, some of which are COENZYMES. (See all compounds classified as Vitamin B Complex.)
THE FAT SOLUBLE VITAMINS A, D, & K ARE ABSORBED FROM SKIN, AS ARE LIPID INSOLUBLE VITAMINS, THIAMINE, RIBOFLAVIN, CALCIUM PANTOTHENATE, PYRIDOXINE. /PYRIDOXINE/
Hayes, W. J., Jr. Toxicology of Pesticides Baltimore: Williams & Wilkins, 1975., p. 149
... READILY ABSORBED FROM GI TRACT. ... EXCRETORY PRODUCT ... OF VITAMIN /WHEN IT IS FED TO MAN IS 4-PYRIDOXIC ACID. /PYRIDOXINE/
Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 1563
Pyridoxine, pyridoxal, and pyridoxamine are readily absorbed from the GI tract following oral administration; however, GI absorption may be diminished in patients with malabsorption syndromes or following gastric resection. Normal serum concentrations of pyridoxine are 30-80 ng/ml.
McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 2000.Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2000 (Plus Supplements)., p. 3318
Vitamin B6 is stored mainly in the liver with lesser amounts in muscle & brain. The total body store of vitamin B6 is estimated to be about 167 mg. Pyridoxal and pyridoxal phosphate, the principal forms of the vitamin present in blood, are highly protein bound. Pyridoxal crosses the placenta, & plasma concn in the fetus are 5 times > maternal plasma concn. The concn of vitamin B6 in milk is about 150 240 mg/mL following maternal intake of 2.5 5 mg of vitamin B6 daily. Following maternal intake of < 2.5 mg of vitamin B6 daily, vitamin B6 concn in milk averages 130 mg/mL.
McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 2000.Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2000 (Plus Supplements)., p. 3318
For more Absorption, Distribution and Excretion (Complete) data for PYRIDOXINE HYDROCHLORIDE (6 total), please visit the HSDB record page.
ALL THREE FORMS OF VITAMIN B6 /PYRIDOXINE, PYRIDOXAL, & PYRIDOXAMINE/ ARE CONVERTED TO PYRIDOXAL PHOSPHATE IN BODY; PYRIDOXAL IS CONVERTED TO PYRIDOXAL PHOSPHATE BY ENZYME, PYRIDOXAL KINASE ... . /PYRIDOXINE/
Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 1570
/4-PYRIDOXIC ACID/ ... FORMED BY ACTION OF HEPATIC ALDEHYDE OXIDASE ON FREE PYRIDOXAL. ADMIN OF PYRIDOXINE ... RESULTS IN INCR EXCRETION OF PYRIDOXAL ... FIRST TRANSFORMED, DIRECTLY OR INDIRECTLY, TO PYRIDOXAL, WHICH IS THEN OXIDIZED TO 4-PYRIDOXIC ACID ... . /PYRIDOXINE/
Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 1571
In erythrocytes, pyridoxine is converted to pyridoxal phosphate and pyridoxamine is converted to pyridoxamine phosphate. In the liver, pyridoxine is phosphorylated to pyridoxine phosphate and transaminated to pyridoxal and pyridoxamine which are rapidly phosphorylated. Riboflavin is required for the conversion of pyridoxine phosphate to pyridoxal phosphate. The principal forms of the vitamin in the blood are pyridoxal and pyridoxal phosphate.
McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 2000.Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2000 (Plus Supplements)., p. 3318
In humans, an exogenous source of vitamin B6, is required for amino acid metab; the vitamin is also involved in carbohydrate & lipid metab. Pyridoxine, pyridoxal, & pyridoxamine are converted to the active forms of the vitamin, pyridoxal phosphate & pyridoxamine phosphate, which act as coenzymes in a wide variety of reactions in intermed metab. The active forms of the vitamin are involved in transamination of amino acids & in the conversion of tryptophan to niacin. Pyridoxine appears to be essential in the synth of y aminobutyric acid (GABA) within the CNS & in the synth of heme. Pyridoxine deficiency results in the accum & urinary excretion of xanthurenic acid (an intermed metabolite of tryptophan) & in decr glutamic oxaloacetic transaminase activity in erythrocytes; measurement of either of these may be used to diagnose pyridoxine deficiency. For detn of xanthurenic acid excretion, an oral loading dose of 2 10 g of tryptophan is usually given; urine is collected for 8 hours & then analyzed for xanthurenic acid. Urinary excretion of vitamin B6 or 4 pyridoxic acid can also be analyzed to determine pyridoxine deficiency.
McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 2000.Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2000 (Plus Supplements)., p. 3318
In the liver pyridoxal is oxidized to 4-pyridoxic acid.
McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 2000.Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2000 (Plus Supplements)., p. 3318
TRITIUM-LABELED PYRIDOXINE HYDROCHLORIDE WAS ADMIN TO RATS. ISOTOPE EXCRETION IN URINE OCCURRED WITH HALF-LIFE OF 40-228 DAYS AFTER THE SECOND DAY OF THE EXPT. THE ELIMINATION RATE OF PYRIDOXINE WAS NOT SIGNIFICANTLY AFFECTED BY PYRIDOXINE HYDROCHLORIDE INTAKE.
PMID:5947254 JOHANSSON S ET AL; AM J PHYSIOL 210 (5): 1086 (1966)
Biologic half-life of pyridoxine appears to be 15-20 days.
McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 2000.Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2000 (Plus Supplements)., p. 3319
BRAIN GABA PRODN BEGAN TO RISE 7.5 MIN AFTER IP ADMIN OF 10 MG PYRIDOXINE HYDROCHLORIDE & CONTINUED FOR 40 MIN, THEN DECLINED.
PMID:1193274 ACKROYD B, SMITH WR D; BIOCHEM SOC TRANS 3 (5): 707 (1975)
NUTRITIONAL NEED FOR VITAMIN B6 IS BASED ON ITS COENZYME FUNCTION IN AN UNUSUALLY LARGE NUMBER OF METABOLIC REACTIONS. ... REQUIRED IN METABOLISM OF AMINO ACIDS, FATS & CARBOHYDRATES & FOR SYNTHESIS OF PHYSIOLOGIC REGULATORS SUCH AS NOREPINEPHRINE, SEROTONIN & HISTAMINE.
Furia, T.E. (ed.). CRC Handbook of Food Additives. 2nd ed. Cleveland: The Chemical Rubber Co., 1972., p. 90
PYRIDOXAL PHOSPHATE IS INVOLVED IN SEVERAL METABOLIC TRANSFORMATIONS OF AMINO ACIDS INCLUDING DECARBOXYLATION, TRANSAMINATION, & RACEMIZATION, AS WELL AS ENZYMATIC STEPS IN METABOLISM OF SULFUR-CONTAINING & HYDROXY AMINO ACIDS. /PYRIDOXINE/
Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 1539
PYRIDOXINE ... IS AN ESSENTIAL PART OF THE ENZYME GLYCOGEN PHOSPHORYLASE. /PYRIDOXINE/
Evaluations of Drug Interactions. 2nd ed. and supplements. Washington, DC: American Pharmaceutical Assn., 1976, 1978., p. 452
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